Current Organic Chemistry - Volume 20, Issue 14, 2016

Rare pentoses, especially L-rare pentoses, have been attracting increasing attention because of their medicinal applications in antiviral and anticancer therapy, where they are used to produce L-nucleoside analogues. To address the problems of low natural abundance and limited synthetic methods for rare pentoses, biological synthesis has emerged recently as promising routes to these valuable compounds. This r Read More

Sialic acids usually occur as glycosides of functional glycoconjugates such as glycoprooteins and glycolips, that are involved in a wide range of biological phenomena, for example, recognition and adhesion of cellcell, recognition by bacteria and viruses, and tumorigenesis and metastasis. So the synthesis of sialosides is an important field in the design of novel medicines and vaccines. In the last decades, significant efforts for i Read More

Disulfide bond plays an important role in various fields, for example, biochemical processes, industrial and pharmaceutical chemistry, bioconjugates, peptidomimetics and selfassembled monolayers (SAMs) etc. In the past decades, drug delivery systems (DDS) have been widely investigated, and disulfide-based oxidation-reduction responsive DDS is the most promising one. Disulfide bonds have no physiological to Read More

Being the first member in the family of nanocarbon superstructures, fullerene C60 (refers to C60 hereafter) continues to be a research focus in physics, chemistry, materials science, biology and life science. The readily available functionalization methods that can be realized on C60 further expand the potential applications of C60 in various fields. Carbohydrates distribute widely in a variety of forms in mammalian animals an Read More

Glyconanoparticles are the subject of numerous literatures and are emerging for applications in biomedicine, glycoscience, and material science due to their unique properties. They are hybrid materials each of which contains a nanoparticle core surrounded by a carbohydrate shell. The core can be metallic, magnetic, and/or photoluminescent, while the shell may be composed of mono-, di-, oligo- and/or poly-saccharides. Sug Read More

Different synthetic strategies to 4,4-disubstituted pyridazines and condensed pyridazines with a special reference to the synthetic routes to their spiro analogues are comprehensively outlined in this review.