Current Organic Chemistry - Volume 20, Issue 24, 2016

The asymmetric hydrogenation of C=C, C=N and C=O bonds catalyzed by chiralligand modified transition metal complexes is a very important process for the organic synthesis and fine chemical production. & A large number of hydrogenation chiral catalysts mainly based on transition metals such as rhodium, ruthenium and iridium have been successfully developed. & Even though outstanding results have been achiev Read More

Currently, dendrimers are molecules widely investigated due to their strong potential for biomedical (including diagnostic, drug discovery, and drug delivery platforms) and others applications. The requirements demanded by Food and Drug Administration (FDA) of a new drug application involve several analytical techniques for characterization, which allow understanding the properties of the novel platforms, and to predict their i Read More

The cyclofunctionalization reactions promoted by electrophilic selenium species are undoubtedly very powerful methodologies in organic chemistry for the construction of different oxygen- and nitrogen-containing heterocycles. If alkene is bearing suitably oriented internal nucleophile, such as OH, COOH, NHR, a variety of heterocyclic compounds, such as ethers, lactones, pyrolidines, piperidines can be synthesized by the usage Read More

Mushrooms have an acclaimed history of therapeutic use in traditional medicine. The prevalent occurrence of infectious diseases is becoming a worldwide problem, due to bacterial resistance against antimicrobial drugs which have been long used for therapeutic and prophylactic purposes. For this reason, the search has intensified for natural sources with antimicrobial activity. The literature contains scientific data about the Read More

A cinchona-catalysed, enantioselective oxa-Michael reaction of α,β-unsaturated aldehydes with either tert-butyl hydroperoxide or cumene hydroperoxide was developed. The reaction was optimised by screening of solvents, modification of the catalyst framework and variation of the acid co-catalysts. A strong relationship was noted between the pKa of the acid co-catalyst and the degree of selectivity. Enantioselective Read More

Halogenation reactions of vindoline and 14,15-dihydrovindoline and its hydrochloric salt were investigated and the anomalous reductions were discussed. Performing the hydrogenation in the presence of chlorine-containing solvent, e.g. dichloromethane, hydrogenolysation reaction of chlorine also took place. In this case unexpected chlorinated product could be observed. Performing the hydrogenation reaction only in t Read More