Current Organic Chemistry - Volume 20, Issue 25, 2016

Mosquito-borne diseases, transmitted by mosquito vectors, continue to cause illness and death in many areas of the world, especially in tropical and subtropical countries. One of the control measures of these diseases has been contingent on mosquito vector control using synthetic chemical insecticides. Due to environmental health concerns of synthetic insecticides and the rise of resistance to synthetic insecticides in mosqui Read More

Important strategies for combating mosquito vectors include the application of larvicides. However, existing larvicides use the active substances of synthetic insecticides, which are often risky substances for both the environment and human health. Therefore new suitable alternatives have been sought, including the development of botanical larvicides based on plant essential oils (EOs). Although they show excellent larvicidal effic Read More

In the near future, a number of molecules employed in insect pest control may lose their efficacy. Pesticide resistance is an increasing problem of public health importance, and more environmental-friendly control approaches against arthropod pests of medical and veterinary relevance are urgently needed. The seed oil of neem, Azadirachta indica (Meliaceae), contains more than 100 biologically active compounds. Many for Read More

Natural products are an ideal source of chemicals for topical application to human skin, and can be a means of personal protection from the bites of mosquitoes and other arthropods. This report covers a diverse array of natural compounds, and includes descriptions of observed correlations between chemical properties and repellency. Repellent efficacy is determined by a ‘cloth-patch’ assay, which involves human volunteers Read More

Peptide nucleic acids (PNAs) are synthetic nucleic acid mimics wherein the sugarphosphate backbone is replaced with a peptide backbone. PNAs hybridize to complementary DNA and RNA with higher affinity and superior sequence selectivity compared with DNA. An important consideration when using PNAs is the possibility of adjusting their chirality in a controlled manner using PNA monomers. The chirality of PNAs plays a Read More

Glutathione is a thiol-containing tripeptide which composed of glutamic acid, cysteine and glycine. Reduced glutathione possesses the function of anti-oxidation, toxinremoving and other crucial physiological functions. Abnormal level of it indicates the emergence of diseases such as hepatitis, pneumonia, AIDS or even cancer. Therefore real-time detection of it has the important significance of keeping normal physiological con Read More

Prolonged exposure to estrogens as hormone replacement therapy agents to relieve menopausal symptoms is linked to an increased risk of breast and other types of human cancers. Previous studies showed the carcinogenic effect of estrogens occurred through formation of carcinogenic/tumor initiating quinone metabolites. Hence, it was found that occupying both ortho-positions by substituents on the A-ring Read More