Current Organic Chemistry - Volume 18, Issue 15, 2014

It is our great pleasure as Guest Editors of the journal ‘Current Organic Chemistry’ to present you with a ‘hot topic issue’ on supramolecular chemistry, 'chemistry beyond the molecule'. Supramolecular chemistry examines the weaker interactions that hold groups of molecules together, no bonds that hold atoms together in a molecule [1]. The weaker interactions provide control, which allows the development of function Read More

The supramolecular self-assembly of polymer chains by specific, directional, and dynamic non-covalent interactions, including hydrogen bonds, host-guest interactions, and amphiphilic associations, has led to the development of novel polymeric supramolecular materials (PSMs). PSMs in the form of micelles, fibers, and hydrogels, which exhibit unique chemical, physical, and biological properties, have been fabricated and sho Read More

Nanopore based DNA Sequencing by Recognition technique relies on the sense of current between a pair of electrodes, which span nanopore and trap DNA nucleotides. The electrodes typically are tips of scanning tunneling microscope (STM) functionalized with recognition molecules that can distinguish individual DNA bases through hydrogen bonds. This manuscript aims to provide a summary of current research progress of n Read More

Supramolecular host-guest chemistry allows sensitive and selective recognition of a certain substrate by using a rationally designed receptor. Such a molecular receptor can be incorporated into an electronic chemical sensor so that the anticipated host-guest binding event can be transduced directly into electric signals. In particular, chemiresistors and chemically sensitive field-effect transistors report the change of conductan Read More

The design and synthesis of molecular container compounds is playing an important role in host–guest chemistry. Porous organic molecular cages (OMCs) represent an exciting type of container-like compounds and have attracted intensive attention in the past few decades. These materials are constructed through covalent bonds and can be synthesized in reasonable yield by making use of dynamic covalent chemistry. Furtherm Read More

Ionic metal-organic frameworks (I-MOFs) are porous crystalline materials with either positively or negatively charged frameworks. The nanosized and charged pores in these ionic architectures provide a strong interaction between the host and guest molecules including enhanced adsorption towards small gases and solvent molecules. Via ion exchange, I-MOFs can be easily modified and accommodate other charged guest m Read More

The reactivity in the confined spaces of zeolites, metal-organic frameworks, cage compounds and macrocycles differ in many aspects from those conducted in bulk solution. Cases of altered regioselectivity, enhanced stability and accelerated substrate reactivity are presented within the context of non-covalent interactions between host and guest molecules, which define much of supramolecular chemistry, being unique Read More

Self-healing or self-repairing materials are ‘smart materials’ that repair damage caused by mechanical force and are a key development of 21st century materials chemistry and engineering. In this review we describe a few excellent examples of self-healing supramolecular polymers based on host-guest interactions and discuss their advantages and versatility.

The recent advances in the development and application of amphiphilic photomicroreactors with “soft” cavities in terms of supramolecular chemistry are reviewed. In this article, we describe how these microreactors alter the photochemical behavior of guests inside their “soft” confined and restrict microenvironment. The main aim is to show the different types of amphiphilic microreactors, the photoreactions occurring Read More

The carbon-carbon double bond offers a possibility to incorporate a cyclopropane ring into a molecule. The special electronic nature of the cyclopropane ring can significantly change the electronic and biological properties of the new derivatives. Herein we present natural compounds containing a fused cyclopropane ring and natural compounds condensed with a cyclopropane ring synthetically.

Detection of single nucleotide polymorphisms (SNPs) is critical for early stage diagnosis. However, available clinical methods for detecting SNPs require strict assay conditions or complicated enzyme reactions. DNA hybridization by Au nanoparticles is a new microscopic method for DNA detection, which offers many advantages over traditional ones. But currently, this method is limitedly used because of low yield of hybri Read More

This book provides exhaustive and timely information about the use of copper compounds as catalysts in asymmetric synthesis. The introductory chapter reflects the importance of bimetallic chiral copper-containing compounds, the so called cuprates, especially in two synthetically useful reactions: the conjugate addition and the allylic substitution, both in an asymmetric fashion. In Chapter 1, the use of mixed cuprates con Read More