Current Organic Chemistry - Volume 18, Issue 12, 2014

Owing to the interest that γ-lactams (pyrrolidin-2-ones) deserve for medicinal and natural products chemistry, the development of novel methodologies for synthesis and decoration of the heterocyclic core has become the objective of many synthetic chemists. This review is presented in two parts: whereas Part I highlighted efficient synthetic strategies directed towards lactam ring formation, Part II deals with transform Read More

Aza heterocycles comprise some rousing structures in biological systems. The aza-Diels-Alder reaction is a [4Π +2Π] cycloaddition, involving a nitrogen atom in either diene or dienophile or both for the generation of unsaturated N-hexacycles. Although aza- Diels-Alder reaction has made a wonderful journey through different stages of development it is still considered as one of the hot topics of research because of procedur Read More

Nucleoside tetraphosphates perform numerous functions in a wide variety of living species from bacteria to complex eukaryotes. In human beings, various nucleoside tetraphosphates have been shown to serve as agonists for a variety of purogenic receptors and kinases, influencing intraocular pressure, platelet activation, vasoconstriction, and extracellular signaling. Also, they are involved in cell division, and bacteria growth an Read More

Deoxyribonucleic acid (DNA), an intrinsic intumescent flame retardant system, able to behave as a char-former, has been melt-blended with an ethylene vinyl acetate copolymer (EVA) at different concentrations (namely, 10, 15 and 20wt.-%). The thermal and fire stability of the obtained compounds has been thoroughly investigated through thermogravimetric analyses (in nitrogen and air), limiting oxygen index and cone Read More

The reactions of 2-iodo-α-methyl styrene (S1) with diphenyl acetylene (S2) (equation 1) and iodo-benzene (S3) with diphenyl acetylene (S2) (equation 2) have been theoretically studied with the aid of density functional theory calculations. Equation 1 reaction involves four major steps, aryl-I oxidative addition, alkyne insertion, C=C bond insertion, and (sp3)C-I reductive elimination. Equation 2 reaction involves aryl-I oxid Read More