Current Organic Chemistry - Volume 18, Issue 16, 2014

Heterocycles are fundamental building blocks for natural products and biologically active compounds. Over the past decades, substantial progress has been made in transition metal-catalyzed C-H bond functionalization. The majority of C-H functionalization studies have been focused on the formation of C-C bond, and the synthesis of heterocyclic compounds has been generally achieved from further elaboration of the resulti Read More

Substituted purine nucleosides and nucleotides are considered as indispensible diagnostic tools since they find different applications in molecular genetics and next generation nucleic acid sequencing. This class of molecules also has pharmaceutical and other biological significance. Both carbon and nitrogen can be used as anchoring points for attaching various kinds of functional labels such as dyes and binding molecules Read More

The indole network has been identified as an important pharmacophore of several natural products and synthetically prepared molecules. Asymmetric organocatalytic Friedel-Crafts alkylations of electron rich indoles are of enormous significance for the synthesis of many bioactive compounds, natural products and anti-cancer drugs. Chiral BrOnsted acid-catalyzed Friedel-Crafts-type reactions of indole and its deriva Read More

Influenza can affect the health of human being and it is considered as the most serious respiratory disease. (–)-Oseltamivir phosphate, also popularly known as Tamiflu, has been reported to be one of the most potent chemotherapeutic agents with oral activity. It can inhibit the viral neuraminidase enzyme to catalyze the cleavage of the sialic acid residue from glycoproteins, thus preventing the infected cells to libera Read More

Recent developments in the microwave-assisted synthesis of carbo- and heterocyclicsystems are reviewed with the focus on diversity-oriented cycloaddition reactions. Ineed, these reactions represent one of the most important endeavors in chemistry and are of considerable interest in the synthesis of carbo-and heterocyclic compounds from simple unsaturated systems, and allow the creation of more than two bonds in one Read More