Current Organic Chemistry - Volume 18, Issue 9, 2014

Cycloaddition reactions of azomethine ylides are the most direct way to synthesise pyrrolidine derivatives. They have been studied for several decades and have become an indispensable tool in synthesis of pyrrolidines and pyrrolidine derived natural products. Amongst many methods for generating azomethine ylides, various processes involving imines derived from amino acid esters have been the most frequently studied Read More

Recent applications of activation parameters variation approach to the elucidation of acyl-transfer mechanisms have led to further clarifications of structures of intermediates and transition states involved in the concerted and stepwise reaction pathways. Acyltransfer reactions in solution are reviewed with special emphasis of activation parameter variation ΔX‡ (X = H, S, G) with substituents in the nucleophile, acyl and leaving Read More

4-Oxothiazolidine core, owing to the wide range of pharmacological activities exhibited by its derivatives, has been recognized as an important structural motif in biologically active compounds. A subclass constitutes 4-oxothiazolidines with an exocyclic C=C double bond at the C(2)-position. Some of these derivatives are registered as active substances for the treatment of various diseases, such as Ralitoline, an antiepileptic, Read More

The concept of sustainable chemistry includes three main parameters; the use of renewable biofeedstock for syntheses of chemical compounds, nontoxic solvents, and eco-friendly processing systems. Until now, many attempts have been made to meet these parameters in chemical synthesis. In hydroxymethylfurfural (HMF) synthesis, most studies have focused on the conversion of cellulosic/ lignocellulosic biomass to Read More

This review provides a comprehensive compilation of available literature concerning the reactions of 1,2- & 1,4- dihydropyridines, which have opened new frontiers in the area of synthetic and medicinal chemistry. These reactions mainly include cycloaddition, 1,3-Dipolar cycloaddition, alkoxy halogenation, diamination, hydroxyamination, oxidation, hydroxylation, photooxygenation reaction, nucleophilic addition, cyclizati Read More

Alkenyl succinic anhydride (ASA) is one of the most prominent paper sizing agents worldwide. Commercial products start from isomerized C16-18 olefins with certain distribution of the double bond along the alkyl chain. This distribution is then found again in the product ASA which renders mechanistic studies on ASA binding to the cellulose surface difficult. For studies on ASA reactivity, olefins with defined double bond locati Read More

We had synthesized a series of β-hydroxy sulfonamides D-glucosamine and applied them as ligands in the titanium tetraisopropoxide-promoted enantioselective addition of phenylacetylene and hexyne-1 to benzaldehyde and selected aromatic and aliphatic aldehydes. The N-3,5-bis(ditrifluoromethyl)benzenesulfonamido-D-glucosamine derivative performed best and we choose it as the most efficient ligand for the Read More