Current Organic Chemistry - Volume 18, Issue 17, 2014

The last century staged a dramatic change in the way people live and interact with the surrounding environment. A shift from an outdoor to an indoor lifestyle took place and, presently, we spend the majority of our existence inside buildings. From our early days in the kindergarten, to our teens in the school, our adulthood in the workplace and our old age in nursing homes, not forgetting “transit times” inside transportation Read More

Dust from indoor environments can contain significant amounts environmental contaminants and is an important source of human exposure to several toxicants. In this article, studies on the occurrence of several emerging environmental contaminants, namely bisphenol A (BPA), tetrabromobisphenol A (TBBPA), phthalates, parabens, and other environmental phenolic compounds in indoor dust from various countri Read More

Perfluoroalkyl substances (PFASs) are emerging pollutants whose scientific knowledge has notably increased in the last two decades. Detectable amounts of PFASs, and particularly perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), have been found in the environment, wildlife and humans. Nowadays, the presence of PFASs and its global distribution is well known. However, there is still a high degree of u Read More

Chlorinated paraffins (CPs), which are also called polychloroalkanes, are chlorination products of n-alkane mixtures. They are classified according to their chain length as short chain (C10-C13), medium chain (C14-C17), and long chain (C20-C30) CPs. The degree of chlorination varies between 30 and over 70%. Considering China, India, U.S.A. and the European Union Countries the current production amount is estimated to be 900, Read More

Modern people spend a considerable time of their life indoors, whether at home, at the workplace or at school, or inside vehicles and public transportation, therefore exposure to a variety of contaminants present indoors is constant and profuse. These contaminants released from household products tend to accumulate and concentrate in dust which is thus considered as one of the main human exposure pathways Read More

Indoor dust is a sink for many kinds of pollutants, including flame retardants (FRs), plasticizers and various degradation products, derived from household products. Recently, we have put particular emphasis on the evaluation of indoor dust as an excellent indicator of important contaminants for chemical risk management throughout the lifecycle of household product. Our research has focused on effect-based a Read More

β-Amino-α-ketoamides 1 are a class of compounds exhibiting biological activity as reversible covalent enzyme inhibitors. The representative examples are clinically approved drugs for the treatment of hepatitis C virus Boceprevir 2 and Telaprevir 3. β-Amino-α- ketoamide substructure is also found in a number of natural products, many of which display a remarkable biological activity. The methods for the synthesis of β-a Read More

Bio-functional microspheres (BFMs), including drug carrier microspheres, fluorescence microspheres, magnetic microspheres, immune microspheres, enzyme immobilization microspheres, solid-phase synthesis microspheres, and molecular imprinting microspheres, are core-shell microspheres containing bio-molecules and functional materials in their structures. Because of the presence of core-shell structures and Read More

A new strategy for the synthesis of trans- and cis + trans-3,4,5-trisubstituted isoxazolines from allyl compounds of QCH2CH=CH2 type (Q = PhO, 2,2’-bithiophen-5-yl, BuO, Me3CS, PhN(COMe) and others) has been developed. The dipolarophiles are prepared via: a) Ru-carbene catalysed metathesis of Qallyl; b) catalytic isomerization followed by Ru-carbene mediated metathesis; c) Ru-carbene catalysed metathesis followe Read More