Current Organic Chemistry - Volume 18, Issue 19, 2014

Tubulin represents a potent target in cancer chemotherapy. Combretastatin is a naturally occurring well known tubulin polymerization inhibitor. Combretastatin and its analogues have been discussed in this review in detail. For better understanding, this review is subdivided as per the carbon distance between to the two aromatic rings. Under these heading, various synthetic analogues, general synthetic route, their brief SAR Read More

Pyridines and their derivatives with various functional groups possess diverse therapeutic and industrial importance. Malononitrile is a versatile reagent in organic chemistry and widely used in various multi-component reactions as a one component for the synthesis of diverse bioactive heterocycles. Malononitrile showed exceptional reactivity than other active methylene group containing compounds due to the presence Read More

Functionalized ionic liquids (FILs) synthesized with specific desired chemical properties have shown promising results in various areas of organic synthesis. In supported organic synthesis, FILs have become known as a new alternative to commonly used PEG and fluorous soluble supports. This review summarizes the progress of recent development in the synthesis of functionalized ionic liquids with emphasis on their application Read More

An efficient tandem and domino protocol for the synthesis of chromeno-, pyrano-, and quinolino- fused spiro[pyrazolo[3,4- b]pyridine-indolines] has been developed. The present method involves one-pot pseudo five-component reaction of hydrazine hydrate and ethyl acetoacetate with isatin, malonitrile/ cyclic β-diketones and ammonium acetate/ primary aromatic amines in ethanol without using catalyst.

In the present paper, novel compounds 1-(2-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol- 3(2H)-yl)-3-(aryl)prop-2-en-1-ones 5a-m were synthesized via cyclization of hydrazone derivative 3 with acetic anhydride and further proceeded by Claisen Schmidt reaction with different aromatic aldehydes. Synthesis of title compounds 5a-m was achieved using both conventional and microwave irr Read More