Current Organic Chemistry - Volume 18, Issue 20, 2014

In continuation with the earlier “Thematic Series - Bioactive Heterocycles, Part 1', this is the second Thematic Series on this vibrant area of bioactive heterocyclic entities. Diversity-oriented synthesis (DOS) is a thriving field involving the preparation of chemical libraries of versatile small molecules for biological screening. The last decade has witnessed tremendous progress in the field, with continued emphasis on structur Read More

Over one billion people worldwide are afflicted by a group of 17 infectious diseases, known as the neglected tropical diseases (NTDs), reaching mainly undeveloped countries that suffer with a lack of economic incentive, research and policy for new drug discovery. Compounds with guanidine moiety are privileged structures and are attractive as scaffold for the discovery of new drug candidates. This functional group is an impo Read More

Propargylic alcohols with aryl/heteroaryl groups at C1 position have received significant attention as alkylating agents in direct nucleophilic SN1-type reactions towards the formation of new C-C, C-O, C-N and C-S bonds. Taking advantage of the versatile alkyne functionality, the obtained propargylated derivatives have been transformed into various types of heterocycles as well as carbocycles. This review demonstrates th Read More

Continuing our research programme to develop the synthesis of small heterocyclic entities, in the present study we prepared carbohydrazides of privileged coumarins through highly attractive Meerwein arylation. The reaction condition is compatible with a wide variety of functional groups present on coumarin and aniline, delivered in moderate to good yields of the target scaffolds. The heterocyclic hydrazide skeletons are c Read More

Polycarbonate (PC)-ZnO NPs composites have been successfully fabricated by solution casting technique in which ZnO NPs (45nm) were prepared via wet chemical method and used as dopant with different concentrations. These nanocomposites were characterized by XRD, SEM, optical micrographs, UV/VIS and FT-IR spectrum. ZnO NPs were uniformly distributed within the PC and create a new recyclable (10 times) catal Read More

A new class of amphiphilic triazolyl peptides was designed and synthesized from peptide-based building blocks containing alkyne and azide functional groups namely linear (W(pG))3, cyclic[W(pG)]3, and Ac-K(N3)R-NH2,where W, R, K, and pG represent tryptophan, arginine, lysine, and propargylglycine residues, respectively. The linear (W(pG))3 and cyclic [W(pG)]3 peptides containing alkyne residues were conjugated wit Read More