Current Organic Chemistry - Volume 15, Issue 16, 2011

Organosilicon chemistry has a considerable and growing importance both in industry and in the academic world. It is an important subject that draws on and contributes to the traditional areas of organic, inorganic, physical, polymer chemistry and materials. This multidisciplinary application gives a unique strength to organosilicon chemistry. The unabated growth of applications of organosilicon in the resolution of synthetic pr Read More

Hydrosilane undergoes useful and interesting Si-C coupling reactions with activated organic compounds such as linear and cyclic alkyl chlorides, polychloromethanes, terminal and internal alkenes, and linear and cyclic conjugated dienes to give a variety of organosilicon compounds with Si-Cl units: 1) thermal induced and Pt-catalyzed hydrosilylation reaction with unsaturated organic compounds, 2) organic salt-catalyzed dehyd Read More

Organosillicon reagents have been found as versatile catalysts or promoters for a broad range of organic reactions due to their special properties of multifunction. An important application of organosilicon reagents is in the research field of multicomponent reactions (MCRs), which provides a vast number of practical synthesis for different molecular libraries. We present in this review the recent research progress of MCRs emp Read More

The aim of this article is to present an overview of new and useful silicon-based methodologies valuable for the selective construction of highly functionalized mono- and bisphosphonic acids of high synthetic and biological importance. The reactions of trimethylsilyl phosphites with alkyl halides, carbonyl compounds and imines are presented as a platform for developing new approaches to biologically active hydroxy-, am Read More

Recent progress in the catalytic hydrosilylation of organic compounds containing carbon-carbon multiple bonds is reviewed. Hydrosilylation of carbon-carbon multiple bonds catalyzed with transition metal complexes remains the most commercially utilized process for formation of organosilicon compounds. During the last two decades, a number of simple and versatile catalytic systems including homogenous and h Read More

Organosilicon compounds are important transmetallation reagents in organic synthesis. Aryltrialkoxysilane have recently emerged as an attractive alternative to traditional organometallic donors, due to their ease of handling, stability toward air/moisture, and/or low toxicity compared to some of the other organometallic reagents (Zn, Mg, Sn, etc.). In this review, the application of aryl trialkoxysilane and alkenyltrialkoxysilane as Read More

The last decade has witnessed a tremendous increase of the studies concerning [3+2] cycloaddition reactions of azides and alkynes. The recent discovery of copper(I) species as efficient catalysts for this transformation is at the origin of this true explosion. In contrast with classical thermal reactions, copper catalysis leads to the regioselective formation of 1,4-disubstituted 1,2,3-triazoles in high yields and under simple reacti Read More

Tri-substituted oxazoles, appearing in several anticancer natural products and various other bioactive compounds, have become increasingly visible in recent years. Research into the synthesis of such oxazoles has led to the development of new synthetic methods as well as refinements of classic methods of their synthesis. In addition, a number of research groups have pursued the synthesis of fully-functionalized-oxazole-containi Read More

The family of cisplatin and its analogues contains some of the most powerful anticancer drugs developed to date and, since their discovery, extensive efforts have been devoted to understand their mode of action. 9-Alkylguanines have featured widely in these studies as model nucleobases. This review describes both the synthesis and the chemical, biological and miscellaneous spectroscopic properties of a vari Read More

In the study of thioanhydrides, a fast, simple, and cost effective means of producing thioanhydrides is necessary being that commercially available thioanhydrides are limited. A simple method of converting an anhydride into a thioanhydride involves the use of sodium sulfide. In general, this method of thioanhydride synthesis is effective in producing a substantial yield of thioanhydride from the conjugate anhydride. However, Read More

This review article summarizes progress in N-alkylations, N-alkenylations, N-and C-arylations and hetarylations, halogenations, as well as organometallic chemistry of pyrazoles mainly achieved during the last decade. In addition, the generation and chemistry of N-heterocyclic carbenes of pyrazole (pyrazol-3-ylidenes) and remote N-heterocyclic carbenes of pyrazole (pyrazol-4-ylidenes) are described.