Current Organic Chemistry - Volume 15, Issue 10, 2011

In modern organic chemistry, nitrogen-containing molecules represent certainly a very important target. Organic nitrogen compounds can possess a variety of interesting properties and are widely used as synthetic intermediates, drugs, additives, crop protection products, advanced materials. Many methods have since long been exploited to create new C-N bonds and a number of useful aminating agents have been proposed a Read More

The purpose of this review is to illustrate the use of ethyl nosyloxycarbamate (NsONHCO2Et). This is a versatile aminating agent known for over 47 years and used to generate, in the presence of organic or inorganic bases under homogeneous conditions, a carbonyl nitrene, a reactive intermediate able to form new C-N or X-N bonds by electrophilic amination reaction of a remarkable variety of nucleophilic substrates. I Read More

The carbanion stabilizing effect of the nitro group makes nitroalkanes ideal reagents in carbon-carbon bond formation. Once introduced in a molecular framework, the nitro group is amenable to further transformations including reduction to primary amines. The aim of this review is to explore the utilization of nitroalkanes as effective substrates for the preparation of important target compounds featured by the amino Read More

The aziridination of olefins mediated by metal-catalyzed generation of nitrenes from iminoiodanes was first described almost a quarter century ago. Since then, great progress has been made in improving the efficiency, versatility and stereocontrol of this important reaction. This review will cover developments made in this area over the last seven years with regard to the various iminoiodanes which have been used, their in Read More

This review focuses on the use of dialkyl azodicarboxylates in the formation of C-N bonds through catalyzed α-amination reactions. Both metal catalyzed and organocatalyzed approaches are covered in the present report.

A review of synthetic methodologies reported in the last five years that yield N-heterocyclic products by intramolecular cyclization of organic azides with a particular emphasis on transformations catalyzed by metal complexes is presented. These reactions have been classified according to the ring size of the formed heterocycle.

Organic carbamates represent an important class of compounds showing various interesting properties. They find wide utility in various areas as pharmaceuticals, agrochemicals (pesticides, herbicides, insecticides, fungicides etc.), intermediates in organic synthesis, protection of amino group in peptide chemistry, and as linker in combinatorial chemistry etc. Classical synthesis of carbamates involves use of harmful reagents su Read More

Heterocyclic compounds, five-membered components in particular, are of great significance in organic and pharmaceutical chemistry. This review highlights the substantial progress and examples, which have been made in the last decade to construct fivemembered heterocycles by transition metal-catalyzed cyclization of propargylic compounds. Propargylic compounds are versatile threecarbon building blocks in heterocyclic Read More

The purpose of this review article is to illustrate synthetic aspects of functionalized phosphorus derivatives containing an oximo moiety at the beta-position. First section will be focused on the synthesis of phosphine oxides, phosphonates or phosphonium salts containing an oxime group. The synthesis of these derivatives comprises the carbon-phosphorus single bond construction by reaction of haloximes with phosphorus deri Read More

S-Alkyl pyrimidine derivatives 2-5 were obtained by the reactions of ethyl 4-sulfanyl-6-methyl-2-phenylpyrimidine-5- carboxylate (1) with allyl bromide, propargyl bromide, epichlorohydrin and vinyl acetate (Scheme 1). On reaction of sulfanylpyrimidine 1 with iodine, hydrogen peroxide under different conditions afforded bisdisulphide, desulphrization, and 4-hydroxypyrimidines 6-8. Treatment of the sulfanylpyrimidine 1 w Read More