Current Organic Chemistry - Volume 15, Issue 7, 2011

Sphingolipids (SLs) are ubiquitous membrane constituents that have emerged as essential lipid mediators involved in signal transduction and cancer development. Due to the implication of SLs in the alteration of cell proliferation, adhesion or migration, their metabolism has been targeted in search for novel anti-cancer therapeutic approaches. In this context, much attention has been directed towards SLs analogues interferin Read More

This review summarizes the recent advances in the field of synthetic fragrance chemistry, with particular emphasis to the following approaches: application of known synthetic protocols to the preparation of new fragrances, lead-structure optimisation of known odorants, and stereoselective synthesis of chiral fragrances.

The review discusses two different reductive metalation approaches to the generation of benzylic organometals. In the first part, the scope of the generation of polar benzylic organometals by the reductive cleavage of carbon - heteroatom sigma bonds will be presented. Besides briefly showing the evolution of the technique, the review deals with recent achievements in the generation of benzylic derivatives of alkali met Read More

The tetracyclic heteroaromatic compounds cryptolepine, isocryptolepine and neocryptolepine are all naturally occurring indoloquinoline alkaloids isolated from the shrub Cryptolepis sanguinolenta and are important due to their wide spectrum of biological properties. This review describes the isolation, brief biological activities and various synthetic methodologies developed during recent years for the preparation of this import Read More

Many reagents have been utilized to accomplish the cyclization of organic compounds to utilize the resulting product in the synthesis of natural products and bioactive compounds. The commercially available iodine has been frequently utilized in the cyclization of several compounds such as olefinic benzyl ethers, dimethylalkenyl malonates, allylic fluorides, propargylic esters, enamides, allylated β-hydroxyketones,4,5-alkadien Read More

Six new arylpiperazinylbenzofurane derivatives as potential hybrid antihypertensive agents were designed and synthesised. The discussed compounds were prepared as free bases and subsequently they were transformed to hydrochloride salts. The position of protonation of nitrogen atoms in the piperazine ring in hydrochloride salts was determined by means of IR spectrometry and 13C CP/MAS and 15N CP/MAS NMR Read More

1,8-Naphthyridine based bi-bracchial macrocyclic 2 and cage-type macrobicyclic receptor 3 bind monosaccharides in water under physiologically relevant conditions through a combination of hydrophobic, electrostatic and hydrogen bonding interactions. The dissociation constants (Kd) for the complexes between 1,8-naphthyridine receptors 1-3 with a variety of neutral and negatively charged monosaccharides in water were d Read More