- Home
- A-Z Publications
- Current Nutraceuticals
- Fast Track Listing
Current Nutraceuticals - Online First
Description text for Online First listing goes here...
-
-
Harnessing Nature's Arsenal: Phytoconstituents Targeting Mediators Involved in Pathogenesis of Asthma
Authors: Sahil Hussain, Badruddeen, Mohd Mursal, Juber Akhtar, Mohammad Irfan Khan and Mohammad AhmadAvailable online: 03 December 2024More LessAsthma is a persistent respiratory disorder characterized by inflammation and constriction of the air passages, resulting in recurrent symptoms, including difficulty breathing, wheezing, coughing, and a sensation of tightness in the chest. It requires ongoing management through medications and lifestyle adjustments. The use of natural bioactive compounds in asthma management is on the rise. Researchers are increasingly exploring the potential of compounds derived from plants and herbs, such as quercetin, resveratrol, and Boswellia extracts, for their anti-inflammatory and bronchodilator properties. Compounds like quercetin and resveratrol are known to reduce inflammation by inhibiting enzymes like PDE4 and LOX-5, which play key roles in asthma-related inflammation. They can additionally regulate immune reactions by inhibiting the secretion of pro-inflammatory cytokines like “IL-6, IL-5, and IL-4”. Additionally, some compounds, like those found in Boswellia extracts, inhibit NF-κB activation, which further reduces the production of inflammatory mediators. These natural remedies offer a promising avenue for complementing traditional asthma treatments, potentially providing relief from symptoms and reducing the reliance on synthetic drugs. The aim of this review is to offer an outline of well-researched plant-derived phytoconstituents that influence cellular activity to control inflammatory mediators associated with asthma. Nevertheless, additional high-quality research is essential to validate the clinical effectiveness of plant-based treatments for asthma.
-
-
-
Effect of Azadirachta indica Leaf Extract on the Toxicity Induced by Ethyl Methanesulphonate (EMS) in the Third Instar Larvae of Transgenic Drosophila melanogaster (hsp70-lacZ) Bg9
Available online: 03 December 2024More LessBackgroundNeem, known for its medicinal benefits, such as anti-inflammatory, antioxidant, and anti-cancer properties, can serve as a complementary or alternative treatment. Research has also indicated that neem extracts lessen the harmful effects of the chemotherapy drug cisplatin on healthy cells while still preserving its ability to target cancer cells effectively. Different parts of the Neem tree, such as leaves, bark, fruit, flowers, oil, and gum, have been traditionally used in herbal medicine for treating various health conditions, including cancer, hypertension, heart disease, and diabetes.
ObjectiveThe effect of neem extract was studied on the Ethyl methanesulphonate (EMS) (an anti-cancerous drug)-induced toxicity in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9.
MethodsThe third instar larvae were exposed to 25 µM of EMS alone and along with 4×10-3g/ml, 8×10-3g/ml, 12×10-3g/ml, and 16×10-3g/ml of neem extract (NE) mixed in diet for 24 hrs.
ResultsA significant increase in toxicity was observed in the larvae exposed to 25 µM of EMS. A dose-dependent significant decrease in the toxic effects was observed in the larvae exposed to various doses of neem extract. The GCMS analysis of the neem extract showed the presence of Phytol and α-tocopherol as major compounds.
ConclusionThe reduction in the toxicity induced by EMS is mainly attributed to phytol and α-tocopherol.
-
-
-
Development and Validation of a High-Performance Thin-Layer Chromatography Method for Qualitative and Quantitative Analysis of Wogonin in S. barbata D. Don Herb
Authors: Arzoo Pannu and Ramesh K. GoyalAvailable online: 11 November 2024More LessBackground and AimsScutellaria barbata D. Don, a perennial herb with a rich history in traditional medicine, is known for its bioactive compounds, including wogonin. It possesses anti-inflammatory, antioxidant, and anticancer properties. Together with other bioactive compounds, wogonin contributes to the pharmacological activities associated with S. barbata D. Don, making it a subject of interest in both traditional and modern medicinal research. This study aimed to develop and validate a High-Performance Thin-Layer Chromatography (HPTLC) method for the precise and accurate quantification of wogonin in the hydroethanolic extract of S. barbata D. Don.
MethodsThe process was developed and underwent rigorous validation following the ICH guidelines. Parameters such as linearity, specificity, instrument precision, precision, accuracy, limit of detection (LOD), limit of quantification (LOQ), and robustness were systematically evaluated to ensure the method's reliability.
ResultsThe HPTLC separation was conducted on TLC aluminum plates precoated with silica gel 60 F254, and optimal separation was achieved using Ethyl acetate: toluene: formic acid (5: 4.9: 0.1, (v/v/v/v)) as the mobile phase. Densitometric scanning at 254 nm in reflection/absorbance mode revealed compact spots at Rf 0.87, corresponding to wogonin. Linear regression analysis demonstrated a robust linear relationship between peak area and the amount of wogonin in the range of 10-40 (µg/mg). The quantification of wogonin in crude extracts obtained was 3.274 µg/mg of extract.
ConclusionIn summary, the developed HPTLC method emerges as a straightforward, precise, and accurate tool for the rapid screening of active constituents, specifically wogonin, within the petroleum ether extracts of S. barbata D. Don. This method holds promise for routine quality control and analysis of herbal materials and formulations containing S. barbata D. Don, contributing to the ongoing exploration of its therapeutic potential.
-
-
-
The Potential Role of Herbal Plants in the Management of Depression: Pre-Clinical and Clinical Evidence
Authors: Arzoo Pannu, Ramesh K. Goyal and Kalicharan SharmaAvailable online: 17 October 2024More LessDepression, a debilitating mental health disorder affecting millions worldwide, continues to challenge the medical community. While several pharmacological interventions exist, their efficacy and side effects often warrant the exploration of alternative treatments. Natural products derived from plants have gained attention for their potential antidepressant properties in preclinical studies. This comprehensive review examines the antidepressant activity of various plant-based extracts through preclinical investigations and explores the underlying mechanisms of action. Our review systematically analyzes the literature, encompassing a wide range of plants. We present evidence from pre-clinical and clinical studies, highlighting the behavioural and neurochemical changes induced by these plant-derived compounds. Furthermore, we delve into the potential mechanisms of action, encompassing modulation of neurotransmitters, anti-inflammatory effects, neurogenesis promotion, and antioxidant properties. The reviewed studies suggest that numerous plants possess promising antidepressant properties, potentially offering novel therapeutic avenues. However, the variability in methodologies and the need for further clinical validation underscore the complexity of translating preclinical findings into effective treatments. This review serves as a valuable resource for researchers and clinicians alike, shedding light on the current state of knowledge regarding plants with antidepressant potential and their underlying mechanisms of action, paving the way for future investigations and therapeutic developments in the field of depression management.
-