Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Nutraceuticals
  4. Volume 3, Issue 1
  5. Article
Volume 3, Issue 1
  • ISSN: 2665-9786
  • E-ISSN: 2665-9794

Abstract

Dyslipidemia is the major risk factor for atherosclerotic cardiovascular disease (ASCVD), cerebrovascular disease, and peripheral artery disease (PAD). It is characterized by higher plasma concentrations of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), apolipoprotein B (apoB), very low-density lipoprotein-cholesterol (VLDL-c), triglycerides (TGs) and low levels of high-density lipoprotein-cholesterol (HDL-c). Herbal medicines are preferred by many across the globe particularly to manage chronic conditions such as dyslipidemia, hypertension, type 2 diabetes, cancer, and plenty of others. (black seeds or black cumin seeds) is a miracle herb employed within the management of many sicknesses for centuries. Hence, this review focuses on the ameliorative effects of on the plasma lipid concentrations of human subjects. Numerous randomized controlled clinical trials (RCTs) and different clinical studies demonstrated that possesses potential anti-dyslipidemic activity. The patients with dyslipidemia may well be benefited by using along with healthy lifestyle changes and statin and other antihyperlipidemic medications as adjuvant therapy if needed.

© 2022 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cnt/10.2174/2665978602666211202102631
2022-02-01
2025-01-10

  • From This Site

    /content/journals/cnt/10.2174/2665978602666211202102631
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. PrestaV. TocciG. VolpeM. Excess of dyslipidemia in low income countries: The case of Colombia in the PURE study.Int. J. Cardiol.201929015215310.1016/j.ijcard.2018.11.10531126735
     [Google Scholar]
  2. CiceroA.F.G. LandolfoM. VenturaF. BorghiC. Current pharmacotherapeutic options for primary dyslipidemia in adults.Expert Opin. Pharmacother.201920101277128810.1080/14656566.2019.160468731059312
     [Google Scholar]
  3. TaghizadehE. EsfehaniR.J. SahebkarA. ParizadehS.M. RostamiD. MirinezhadM. PoursheikhaniA. MobarhanM.G. PasdarA. Familial combined hyperlipidemia: An overview of the underlying molecular mechanisms and therapeutic strategies.IUBMB Life20197191221122910.1002/iub.207331271707
     [Google Scholar]
  4. VodnalaD. RubenfireM. BrookR.D. Secondary causes of dyslipidemia.Am. J. Cardiol.2012110682382510.1016/j.amjcard.2012.04.06222658245
     [Google Scholar]
  5. MahmoudI. SulaimanN. Dyslipidaemia prevalence and associated risk factors in the United Arab Emirates: A population-based study.BMJ Open2019911e03196910.1136/bmjopen‑2019‑03196931699740
     [Google Scholar]
  6. GrundyS.M. StoneN.J. BaileyA.L. BeamC. BirtcherK.K. BlumenthalR.S. BraunL.T. de FerrantiS. Faiella-TommasinoJ. FormanD.E. GoldbergR. HeidenreichP.A. HlatkyM.A. JonesD.W. Lloyd-JonesD. Lopez-PajaresN. NdumeleC.E. OrringerC.E. PeraltaC.A. SaseenJ.J. SmithS.C.Jr SperlingL. ViraniS.S. YeboahJ. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: A report of the American college of cardiology/American heart association task force on clinical practice guidelines.J. Am. Coll. Cardiol.20197324e285e35010.1016/j.jacc.2018.11.00330423393
     [Google Scholar]
  7. MachF. BaigentC. CatapanoA.L. KoskinasK.C. CasulaM. BadimonL. ChapmanM.J. De BackerG.G. DelgadoV. FerenceB.A. GrahamI.M. HallidayA. LandmesserU. MihaylovaB. PedersenT.R. RiccardiG. RichterD.J. SabatineM.S. TaskinenM.R. TokgozogluL. WiklundO. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk.Eur. Heart J.202041111118810.1093/eurheartj/ehz45531504418
     [Google Scholar]
  8. BalasubramanianR. MaideenN.M.P. HMG-CoA reductase inhibitors (statins) and their drug interactions involving CYP enzymes, P-glycoprotein and OATP transporters-an overview.Curr. Drug Metab.202122532834110.2174/138920022266621011412272933459228
     [Google Scholar]
  9. ZoddaD. GiammonaR. SchifillitiS. Treatment strategy for dyslipidemia in cardiovascular disease prevention: Focus on old and new drugs.Pharmacy (Basel)2018611010.3390/pharmacy601001029361723
     [Google Scholar]
  10. BartlomiejczykM.A. PensonP. BanachM. Worldwide dyslipidemia guidelines.Curr. Cardiovasc. Risk Rep.2019132210.1007/s12170‑019‑0597‑x
     [Google Scholar]
  11. MaideenN.M. BalasubramanianR. RamanathanS. Nigella sativa (Black seeds), a potential herb for the pharmacotherapeutic management of hypertension-a review.Curr. Cardiol. Rev.2020174e23042118778610.2174/1573403X1666620111012590633172379
     [Google Scholar]
  12. MaideenN.M.P. Antidiabetic activity of Nigella sativa (black seeds) and its active constituent (thymoquinone): A review of human and experimental animal studies.Chonnam Med. J.202157316917510.4068/cmj.2021.57.3.16934621636
     [Google Scholar]
  13. DehkordiF.R. KamkhahA.F. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension.Fundam. Clin. Pharmacol.200822444745210.1111/j.1472‑8206.2008.00607.x18705755
     [Google Scholar]
  14. IbraheimZ.Z. Effect of Nigella sativa seeds and total oil on some blood parameters in female volunteers.Saudi Pharm. J.2002105459
     [Google Scholar]
  15. BamosaA.O. BasilA. SowayanA.A. SowayanS.A. Effect of oral ingestion of Nigella sativa seeds on some blood parameters.Saudi Pharm. J.199722-3126129
     [Google Scholar]
  16. BilalA. MasudT. UppalA.M. BS5-5 Black seed (Nigella sativa) regulates glucose, insulin level and lipid profile in patients with type 2 diabetes.Diabetes Res. Clin. Pract.200879S19S2010.1016/S0168‑8227(08)70696‑X
     [Google Scholar]
  17. NajmiA. NasiruddinM. KhanR.A. HaqueS.F. Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome.Int. J. Diabetes Dev. Ctries.2008281111410.4103/0973‑3930.4198019902033
     [Google Scholar]
  18. QidwaiW. HamzaH.B. QureshiR. GilaniA. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: Results of a randomized, double-blind controlled trial.J. Altern. Complement. Med.200915663964410.1089/acm.2008.036719500003
     [Google Scholar]
  19. BhattiI.U. RehmanF.U. KhanM.A. MarwatS.K. Effect of prophetic medicine kalonji (Nigella sativa L.) on lipid profile of human beings: An in vivo approach.World Appl. Sci. J.20096810531057
     [Google Scholar]
  20. DatauE.A. Wardhana SurachmantoE.E. PandelakiK. LangiJ.A. Fias Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male.Acta Med. Indones.201042313013420724766
     [Google Scholar]
  21. AminiM. Fallah HuseiniH. MohtashamiR. SadeqhiZ. GhamarchehreM.A. Hypolipidemic effects of Nigella sativa L. seeds oil in healthy volunteers: A randomized, double-blind, placebo- controlled clinical trial.J. Med. Plants20111040133138
     [Google Scholar]
  22. TasawarZ. SirajZ. AhmadN. LashariM.H. The effects of Nigella sativa (kalonji) on lipid profile in patients with stable coronary artery disease in Multan, Pakistan.Pak. J. Nutr.20111016216710.3923/pjn.2011.162.167
     [Google Scholar]
  23. SabzghabaeeA.M. DianatkhahM. SarrafzadeganN. AsgaryS. GhannadiA. Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: A randomized, placebo controlled clinical trial.Med. Arh.201266319820010.5455/medarh.2012.66.198‑20022822623
     [Google Scholar]
  24. KaatabiH. BamosaA.O. LebdaF.M. Al ElqA.H. Al-SultanA.I. Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients.J. Family Community Med.201219315516110.4103/2230‑8229.10231123230380
     [Google Scholar]
  25. MemonA.R. ShahS.S. MemonA.R. NaqviS.H. Effect of combination of Nigella sativa and Trigonella foenum-graecum with glibenclamide on serum triglyceride, HDL and creatinine levels in type-2 diabetes mellitus patients.Pak. J. Pharmacol.201229116
     [Google Scholar]
  26. ShahA.S. KhanG.M. BadshahA. ShahS.U. ShahK.U. MirzaS.A. KhanK.A. Nigella sativa provides protection against metabolic syndrome.Afr. J. Biotechnol.20121148109191092510.5897/AJB12.890
     [Google Scholar]
  27. NajmiA.H. NasiruddinM.O. KhanR.A. HaqueS.F. Therapeutic effect of Nigella sativa in patients of poor glycemic control.Asian J. Pharm. Clin. Res.201253224228
     [Google Scholar]
  28. HosseiniM.S. MirkarimiS.A. AminiM. MohtashamiR. KianbakhtS. Huseini H.F. Effects of Nigella sativa L. seed oil in type II diabetic Patients: A randomized, double-blind, placebo- controlled clinical trial.J. Med. Plants201312479399
     [Google Scholar]
  29. NajmiA.H. NasiruddinM.O. KhanR.A. HaqueS.F. Indigenous herbal product Nigella sativa proved effective as an antihypertensive in metabolic syndrome.Asian J. Pharm. Clin. Res.2013616164
     [Google Scholar]
  30. Bin SayeedM.S. AsaduzzamanM. MorshedH. HossainM.M. KadirM.F. RahmanM.R. The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers.J. Ethnopharmacol.2013148378078610.1016/j.jep.2013.05.00423707331
     [Google Scholar]
  31. BasharT. MisbahuddinM. HossainM.A. A double-blind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmar arsenical keratosis patients.Bangladesh J. Pharmacol.201491152110.3329/bjp.v9i1.17167
     [Google Scholar]
  32. Moeen-ud-dinH. MuradS. FatimaA. Placebo controlled study on comparison of effects of Nigella sativa and nicotinic acid along with low fat diet and physical exercise on LDL-cholesterol and HDL-cholesterol.Pak. J. Med. Health Sci.20148306309
     [Google Scholar]
  33. FatimaA. ShadM.N. AsrarA. MuradS. Effects of Nigella sativa on HDL-c & body weight.Pak. J. Med. Health Sci.201481122124
     [Google Scholar]
  34. FarzanehE. NiaF.R. MehrtashM. MirmoeiniF.S. JalilvandM. The effects of 8-week Nigella sativa supplementation and aerobic training on lipid profile and VO2 max in sedentary overweight females.Int. J. Prev. Med.20145221021624627749
     [Google Scholar]
  35. Ahmad AlobaidiA.H. Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in dyslipidemia patients: A prospective, randomized, double-blind trial.Antiinflamm. Antiallergy Agents Med. Chem.2014131687410.2174/1871523011312999001323848231
     [Google Scholar]
  36. IbrahimR.M. HamdanN.S. IsmailM. SainiS.M. Abd RashidS.N. Abd LatiffL. MahmudR. Protective effects of Nigella sativa on metabolic syndrome in menopausal women.Adv. Pharm. Bull.201441293310.5681/apb.2014.00524409406
     [Google Scholar]
  37. IbrahimR.M. HamdanN.S. MahmudR. ImamM.U. SainiS.M. RashidS.N. Abd GhafarS.A. LatiffL.A. IsmailM. A randomised controlled trial on hypolipidemic effects of Nigella sativa seeds powder in menopausal women.J. Transl. Med.20141218210.1186/1479‑5876‑12‑8224685020
     [Google Scholar]
  38. LatiffL.A. ParhizkarS. DollahM.A. HassanS.T. Alternative supplement for enhancement of reproductive health and metabolic profile among perimenopausal women: A novel role of Nigella sativa.Iran. J. Basic Med. Sci.2014171298098525859301
     [Google Scholar]
  39. MirmiranP. Hosseinpour-NiaziS. HedayatiM. AziziF. Effect of Nigella sativa oil extract on lipid profiles in type 2 diabetic patients: A randomized, double blind, placebo-controlled clinical trial.Iraninan J. Endocrinol. Metabol.2015166411418
     [Google Scholar]
  40. AminF. IslamN. AnilaN. GilaniA.H. Clinical efficacy of the co-administration of Turmeric and black seeds (kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial.Complement. Ther. Med.201523216517410.1016/j.ctim.2015.01.00825847554
     [Google Scholar]
  41. HeshmatiJ. NamaziN. MemarzadehM.R. TaghizadehM. KolahdoozF. Nigella sativa oil affects glucose metabolism and lipid concentrations in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial.Food Res. Int.201570879310.1016/j.foodres.2015.01.030
     [Google Scholar]
  42. MahdaviR. NamaziN. AlizadehM. FarajniaS. Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: A randomized controlled clinical trial.Food Funct.2015662041204810.1039/C5FO00316D26029855
     [Google Scholar]
  43. NiazK. QudoosA. FatimaA. MuradS. Placebo-controlled study on comparison of two herbal hypolipidemic agents.J. Drug Deliv. Ther.20166171010.22270/jddt.v6i1.1168
     [Google Scholar]
  44. MohtashamiA. MahakiB. AzadbakhtL. EntezariM.H. Effects of bread with Nigella sativa on lipid profiles, apolipoproteins and inflammatory factor in metabolic syndrome patients.Clin. Nutr. Res.201652899510.7762/cnr.2016.5.2.8927152298
     [Google Scholar]
  45. BadarA. KaatabiH. BamosaA. Al-ElqA. Abou-HozaifaB. LebdaF. AlkhadraA. Al-AlmaieS. Effect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: Nonrandomized clinical trial.Ann. Saudi Med.2017371566310.5144/0256‑4947.2017.5628151458
     [Google Scholar]
  46. FarhangiM.A. DehghanP. TajmiriS. Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto’s thyroiditis.Lipids Health Dis.20181715910.1186/s12944‑018‑0704‑x29587770
     [Google Scholar]
  47. KhoncheA. HuseiniH.F. GholamianM. MohtashamiR. NabatiF. KianbakhtS. Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: A randomized, double-blind and placebo-controlled clinical trial.J. Ethnopharmacol.201923410611110.1016/j.jep.2019.01.00930639231
     [Google Scholar]
  48. PelegrinS. GaltierF. ChalançonA. GagnolJ.P. BarbanelA.M. PélissierY. LarroqueM. LepapeS. FaucaniéM. GabillaudI. PetitP. ChevassusH. Effects of Nigella sativa seeds (black cumin) on insulin secretion and lipid profile: A pilot study in healthy volunteers.Br. J. Clin. Pharmacol.20198571607161110.1111/bcp.1392230875097
     [Google Scholar]
  49. RashidmayvanM. MohammadshahiM. SeyedianS.S. HaghighizadehM.H. The effect of Nigella sativa oil on serum levels of inflammatory markers, liver enzymes, lipid profile, insulin and fasting blood sugar in patients with non-alcoholic fatty liver.J. Diabetes Metab. Disord.201918245345910.1007/s40200‑019‑00439‑631890671
     [Google Scholar]
  50. DarandM. DarabiZ. YariZ. HedayatiM. ShahrbafM.A. KhonchehA. Hosseini-AhangarB. AlavianS.M. HekmatdoostA. The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled clinical trial.Phytother. Res.20193392369237710.1002/ptr.642431293021
     [Google Scholar]
  51. GhorbaniA ZarvandiM RakhshandehH. A randomized controlled trial of a herbal compound for improving metabolic parameters in diabetic patients with uncontrolled dyslipidemia.Endocr. Metab. Immune Disord. Drug Targets20191971075108210.2174/187153031966619020621342030727929
     [Google Scholar]
  52. ElfoulyA.E. IsmailM.A. KamalH.M. AhmedS.A. FialaL.E. A randomized controlled trial measuring the effect of Nigella sativa extract on lipid profile in adult patients with dyslipidemia attending family practice clinic, Suez Canal university hospital, Egypt.Pharm Innov J201987262267
     [Google Scholar]
  53. ShariFH RamadhanHH MohammedRN Al BahadilyDC Hypolipidemic and antioxidant effects of Fenugreek-Nigella sativa combination on diabetic patients in Iraq.Sys. Rev. Pharm.2020116911915
     [Google Scholar]
  54. FarhangiM.A. TajmiriS. The effects of powdered black cumin seeds on markers of oxidative stress, intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in patients with Hashimoto’s thyroiditis.Clin. Nutr. ESPEN20203720721210.1016/j.clnesp.2020.02.01532359745
     [Google Scholar]
  55. HadiS. Daryabeygi-KhotbehsaraR. MirmiranP. McVicarJ. HadiV. SoleimaniD. AskariG. Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial.Phytother. Res.20213573747375510.1002/ptr.699034142392
     [Google Scholar]
  56. Jangjo-BorazjaniS. DastgheibM. KiyamarsiE. JamshidiR. Rahmati-AhmadabadS. HelalizadehM. IrajiR. CornishS.M. Mohammadi-DarestaniS. KhojastehZ. AzarbayjaniM.A. Effects of resistance training and Nigella sativa on type 2 diabetes: implications for metabolic markers, low-grade inflammation and liver enzyme production.Arch. Physiol. Biochem.20211910.1080/13813455.2021.188611733612031
     [Google Scholar]
  57. SafiS. RazmpooshE. FallahzadehH. MazaheriM. AbdollahiN. NazariM. NadjarzadehA. Salehi-AbargoueiA. The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: A crossover, double-blind, placebo-controlled, randomized clinical trial.Complement. Ther. Med.20215710265310.1016/j.ctim.2020.10265333370571
     [Google Scholar]
  58. RazmpooshE. SafiS. NadjarzadehA. FallahzadehH. AbdollahiN. MazaheriM. NazariM. Salehi-AbargoueiA. The effect of Nigella sativa supplementation on cardiovascular risk factors in obese and overweight women: A crossover, double-blind, placebo-controlled randomized clinical trial.Eur. J. Nutr.20216041863187410.1007/s00394‑020‑02374‑232876804
     [Google Scholar]
  59. MaideenN.M. Clinically important and pharmacologically relevant drug interactions with alcohol.Am J Res Med Sci.20196110.5455/ajrms.20190602042343
     [Google Scholar]
/content/journals/cnt/10.2174/2665978602666211202102631
Loading
Effects of Nigella Sativa (Black seeds) Supplementation on Plasma Lipid Profile in Human Subjects - A Review
Current Nutraceuticals 3, e021221198487 (2022); https://doi.org/10.2174/2665978602666211202102631
/content/journals/cnt/10.2174/2665978602666211202102631
/content/journals/cnt/10.2174/2665978602666211202102631
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): black seeds; dyslipidemia; hypercholesterolemia; hyperlipidemia; hypertriglyceridemia; kalonji; Nigella sativa; nigellone; thymoquinone

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test