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- Volume 22, Issue 4, 2024
Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents) - Volume 22, Issue 4, 2024
Volume 22, Issue 4, 2024
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Psychosomatic Disorder: The Current Implications and Challenges
Authors: Abhimanyu Chauhan and Chakresh Kumar JainIn recent years, there has been increasing global concern about the rising prevalence and rapid progression of psychosomatic disorders (PD). This surge can be attributed to irregular biological conditions and the increasingly stressful lifestyles that individuals lead, ultimately resulting in functional impairments of vital organs. PD arises from intricate interactions involving the central nervous, endocrine, and immune syste Read More
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Understanding the Relationship between the Ketogenic Diet and the Heart: A Novel Therapeutic Potential for Cardiovascular Health
Obesity and cardiovascular diseases are major health problems worldwide, and weight loss is used as a treatment strategy to enhance various aspects. While there are many weight loss methods, one of the most effective is through a dietary approach. The ketogenic diet (KD), which is characterized by low carbohydrates and high levels of fat and/or protein, is used in obese patients as it is a promising treatment option f Read More
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Endothelial Cell Aging and Autophagy Dysregulation
More LessEntropy is a natural process that affects all living cells, including senescence, an irreversible physiological process that impairs cell homeostasis. Age is a significant factor in disease development, and the pathogenesis of endothelial cell aging is multifactorial. Autophagy dysfunction accelerates endothelial cell aging and cell death, while autophagy preserves endothelial cell youthfulness through intracellular homeost Read More
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Drug-herb Synergistic Interactions between Clopidogrel and Natural Medicine
Authors: Shitang Ma, Qin Zhang, Jiafu Hou, Shijuan Liu and Chengtao FengIntroduction Natural medicine (NM) has been used since ancient times for therapeutic purposes worldwide. Presently, the combination of clopidogrel and NM with a reasonable synergistic effect has gained increasing acceptance in clinical therapeutics. Methods Here, we have performed a comprehensive retrieval of literature published in both English and Chinese databases until August 1, 2022, studying the sy Read More
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Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats
Authors: Ismail Bouadid, Adil Qabouche and Mohamed EddouksAims The antihypertensive activity of Daphne gnidium was tested. Background Daphne gnidium (Thymelaeaceae) is used against hypertension. Objective The antihypertensive effect of Daphne gnidium was evaluated in this study. Methods The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested. Read More
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Therapeutic Potential of Syzygium aromaticum in Gut Dysbiosis via TMAO Associated Diabetic Cardiomyopathy
Authors: Shivani Singhal and Vibha RaniBackground Dysbiosis of the gastrointestinal microbiota is not only related to the pathogenesis of intestinal disorders but also associated with extra-intestinal diseases. Various studies have revealed the role of an imbalance of intestinal microbiota and their metabolites including bile acids, indole derivatives, polyamines, and trimethylamine in the progression of various diseases. The elevated plasma level of the oxidized form of tri Read More
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Evaluation of Quercetin's Bioenhancing Effect on Oral Pharmacokinetics of Rosuvastatin in Wistar Rats Using RP-HPLC Method
Authors: Rachana S. Bhimanwar, Lata P. Kothapalli and Akshay KhawshiBackground The absolute oral bioavailability of rosuvastatin (RST), a second-generation statin, is low i.e. 20% and only 10% is recovered as metabolite N-desmethy l rosuvistatin. Since it is a hydrophilic statin, RST relies on the organic anion transporting polypeptide-1B1 (OATP-1B1), as the key mechanism for active transport into hepatocytes. Quercetin (QUE) being a bio enhancer and inhibitor of OATP1B1 can augment Read More
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Incidence Rate of Post Coronary Artery Shunt Complications; Age Dependent!
More LessBackground Numerous complications, such as postoperative arrhythmia and stroke, have been observed following coronary artery bypass graft (CABG) surgery. Aims This study sought to examine the impact of aging on the incidence of post-coronary artery shunt complications. Objectives Aging is a physiological process experienced by every living cell, beginning early in development. Age plays a crucial role in determining Read More
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Cardioprotective Role of Tinospora cordifolia against Trimethylamine-N-Oxide and Glucose Induced Stress in Rat Cardiomyocytes
Authors: Shivani Singhal and Vibha RaniBackground Type 2 diabetes has become a concern issue that affects the quality of life and can increase the risk of cardiac insufficiency elevating the threat to the life safety of patients. A recognized cause of cardiac insufficiency is diabetic cardiomyopathy, chronic hyperglycemia, and myocardial lipotoxicity which can reduce the myocardial contractile performance, and enhance the cardiomyocyte hypertrophy and inte Read More
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Can Rosuvastatin Reduce the Risk of Thrombosis in Patients with Hypercholesterolemia with its Effect on Coagulation Factors and Homocysteine Levels?
Authors: Mostafa Behnam, Mohammad Reza Deyhim and Parichehreh YaghmaeiBackground and Objectives Hypercholesterolemia is one of the main risk factors for vascular thrombosis in individuals. Therefore, the use of statins is very effective in reducing cholesterol and can reduce the risk of thrombosis in these patients. Rosuvastatin, a member of the statin family which, inhibits cholesterol synthesis. Very few studies have been done in relation to how rosuvastatin can affect thrombosis. So, this research h Read More
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Comparison between the ECG Outcomes of Metoprolol and Bisoprolol
Background Beta-blockers are essential agents in the management of cardiovascular diseases, such as heart failure, acute myocardial infarction (MI), and cardiac arrhythmias. However, there are diurnal variations in the cardioprotective effects of the subgroups as a result of their different pharmacokinetic, pharmacodynamic, and pharmacogenetic profiles. Objectives We aimed to compare metoprolol and bisoprolol in term Read More
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Volumes & issues
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Volume 23 (2025)
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Volume 22 (2024)
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Volume 21 (2023)
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Volume 20 (2022)
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Volume 19 (2021)
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Volume 18 (2020)
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Volume 2 (2020)
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Volume 17 (2019)
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Volume 16 (2018)
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Volume 15 (2017)
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Volume 14 (2016)
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Volume 13 (2015)
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Volume 12 (2014)
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Volume 11 (2013)
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Volume 10 (2012)
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Volume 9 (2011)
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Volume 8 (2010)
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Volume 7 (2009)
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Volume 6 (2008)
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Volume 5 (2007)
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Volume 4 (2006)
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