Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)
  4. Volume 22, Issue 4
  5. Article
Volume 22, Issue 4
  • ISSN: 1871-5257
  • E-ISSN: 1875-6182

Abstract

Aims

The antihypertensive activity of was tested.

Background

(Thymelaeaceae) is used against hypertension.

Objective

The antihypertensive effect of was evaluated in this study.

Methods

The effect of aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.

Results

DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptor-activated calcium channels (ROCCs) without affecting ACE-2.

Conclusion

The aqueous extract of exhibits antihypertensive activity and induces vasodilatation the inhibition of Ca2+ entry.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/chamc/10.2174/0118715257251651231212045407
2024-12-01
2024-11-22

  • From This Site

    /content/journals/chamc/10.2174/0118715257251651231212045407
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. RavenP.B. ChapleauM.W. Blood pressure regulation XI: Overview and future research directions.Eur. J. Appl. Physiol.2014114357958610.1007/s00421‑014‑2823‑z 24463603
     [Google Scholar]
  2. OparilS. AcelajadoM.C. BakrisG.L. BerlowitzD.R. CífkováR. DominiczakA.F. GrassiG. JordanJ. PoulterN.R. RodgersA. WheltonP.K. Hypertension.Nat. Rev. Dis. Primers2018411801410.1038/nrdp.2018.14 29565029
     [Google Scholar]
  3. ZhouB. PerelP. MensahG.A. EzzatiM. Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension.Nat. Rev. Cardiol.2021181178580210.1038/s41569‑021‑00559‑8 34050340
     [Google Scholar]
  4. ChaabaneF. BoubakerJ. LoussaifA. NeffatiA. Kilani-JaziriS. GhediraK. Chekir-GhediraL. Antioxidant, genotoxic and antigenotoxic activities of daphne gnidium leaf extracts.BMC Complement. Altern. Med.201212115310.1186/1472‑6882‑12‑153 22974481
     [Google Scholar]
  5. KhouchlaaA. El MenyiyN. GuaouguaouF.E. El BaabouaA. CharfiS. LakhdarF. El OmariN. TahaD. ShariatiM.A. RebezovM. El-ShazlyM. BouyahyaA. Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Daphne gnidium: A review.J. Ethnopharmacol.202127511412410.1016/j.jep.2021.114124 33865924
     [Google Scholar]
  6. ChaabaneF. PinonA. SimonA. GhediraK. Chekir-GhediraL. Phytochemical potential of Daphne gnidium in inhibiting growth of melanoma cells and enhancing melanogenesis of B16‐F0 melanoma.Cell Biochem. Funct.201331646046710.1002/cbf.2919 23080382
     [Google Scholar]
  7. HorchaniA. ChaabaneF. BarbouraM. Mokdad-BzeouichI. AbbassiA. TrabelsiA. Chekir-GhediraL. Phytochemistry and biological evaluation of Daphne gnidium L. butanol extract.Pharmacogn. J.2021136s1688169310.5530/pj.2021.13.217
     [Google Scholar]
  8. ChaoukiW. LegerD.Y. LiagreB. CherrahY. BeneytoutJ.L. HmamouchiM. Roots of daphne gnidium L. inhibit cell proliferation and induce apoptosis in the human breast cancer cell line MCF-7.Pharmazie2009648542546 19746845
     [Google Scholar]
  9. ChaabaneF. MustaphaN. Mokdad-BzeouichI. SassiA. Kilani-JaziriS. Dijoux FrancaM.G. MichaletS. FathallahM. KrifaM. GhediraK. Chekir-GhediraL. In vitro and in vivo anti-melanoma effects of daphne gnidium aqueous extract via activation of the immune system.Tumour Biol.20163756511651710.1007/s13277‑015‑4492‑x 26637225
     [Google Scholar]
  10. HariziH. ChaabaneF. GhediraK. Chekir-GhediraL. Inhibition of proinflammatory macrophage responses and lymphocyte proliferation in vitro by ethyl acetate leaf extract from Daphne gnidium.Cell. Immunol.201126729410110.1016/j.cellimm.2010.12.002 21190680
     [Google Scholar]
  11. CottigliF. LoyG. GarauD. FlorisC. CasuM. PompeiR. BonsignoreL. Antimicrobial evaluation of coumarins and flavonoids from the stems of L.Phytomedicine20018430230510.1078/0944‑7113‑00036 11515721
     [Google Scholar]
  12. VidalV. PotteratO. LouvelS. HamyF. MojarrabM. SanglierJ.J. KlimkaitT. HamburgerM. Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium.J. Nat. Prod.201275341441910.1021/np200855d 22148316
     [Google Scholar]
  13. EddouksM. BouadidI. AmssayefA. Study of the antihypertensive effect of laurus nobilis in rats.Cardiovasc. Hematol. Agents Med. Chem.2023211425410.2174/1871525720666220512154041 35549860
     [Google Scholar]
  14. EddouksM. BouadidI. AkdadM. Antihypertensive activity of prunus armeniaca in hypertensive rats.Cardiovasc. Hematol. Agents Med. Chem.2023211203010.2174/1871525720666220613164559 35702770
     [Google Scholar]
  15. AjebliM. EddouksM. Antihypertensive activity of petroselinum crispum through inhibition of vascular calcium channels in rats.J. Ethnopharmacol.201924211203910.1016/j.jep.2019.112039 31252093
     [Google Scholar]
  16. AmssayefA. BouadidI. EddouksM. VitaminC. Vitamin C inhibits angiotensin-converting enzyme-2 in isolated rat aortic ring.Cardiovasc. Hematol. Disord. Drug Targets202121423524210.2174/1871529X21666211214153308 34906063
     [Google Scholar]
  17. BootmanM.D. CollinsT.J. MackenzieL. RoderickH.L. BerridgeM.J. PeppiattC.M. 2‐Aminoethoxydiphenyl borate (2‐APB) is a reliable blocker of store‐operated Ca 2+ entry but an inconsistent inhibitor of InsP 3 ‐induced Ca 2+ release.FASEB J.200216101145115010.1096/fj.02‑0037rev 12153982
     [Google Scholar]
  18. PeppiattC.M. CollinsT.J. MackenzieL. ConwayS.J. HolmesA.B. BootmanM.D. BerridgeM.J. SeoJ.T. RoderickH.L. 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels.Cell Calcium20033419710810.1016/S0143‑4160(03)00026‑5 12767897
     [Google Scholar]
  19. IwasakiH. MoriY. HaraY. UchidaK. ZhouH. MikoshibaK. 2-Aminoethoxydiphenyl borate (2-APB) inhibits capacitative calcium entry independently of the function of inositol 1,4,5-trisphosphate receptors.Receptors Channels200176429439 11918346
     [Google Scholar]
  20. BilmenJ.G. WoottonL.L. GodfreyR.E. SmartO.S. MichelangeliF. Inhibition of SERCA Ca 2+ pumps by 2-aminoethoxydiphenyl borate (2-APB).Eur. J. Biochem.2002269153678368710.1046/j.1432‑1033.2002.03060.x 12153564
     [Google Scholar]
  21. HoeS.Z. LeeC.N. MokS.L. KamaruddinM.Y. LamS.K. Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels.Clinics201166114315010.1590/S1807‑59322011000100025 21437451
     [Google Scholar]
  22. MeisheriK.D. HwangO. van BreemenC. Evidence for two separate Ca2+ pathways in smooth muscle plasmalemma.J. Membr. Biol.1981591192510.1007/BF01870817 7241573
     [Google Scholar]
  23. YamamotoH. van BreemenC. Ca2+ compartments in saponin-skinned cultured vascular smooth muscle cells.J. Gen. Physiol.198687336938910.1085/jgp.87.3.369 3514788
     [Google Scholar]
  24. ChaumaisM.C. MacariE.A. SitbonO. Calcium-channel blockers in pulmonary arterial hypertension.Handb. Exp. Pharmacol.201321816117510.1007/978‑3‑642‑38664‑0_7 24092340
     [Google Scholar]
  25. LinQ. ZhaoG. FangX. PengX. TangH. WangH. JingR. LiuJ. LedererW.J. ChenJ. OuyangK. IP3 receptors regulate vascular smooth muscle contractility and hypertension.JCI Insight2016117e8940210.1172/jci.insight.89402 27777977
     [Google Scholar]
  26. KarakiH. OzakiH. HoriM. Mitsui-SaitoM. AmanoK. HaradaK. MiyamotoS. NakazawaH. WonK.J. SatoK. Calcium movements, distribution, and functions in smooth muscle.Pharmacol. Rev.1997492157230 9228665
     [Google Scholar]
  27. MaioneF. CicalaC. MusciaccoG. De FeoV. AmatA.G. IalentiA. MascoloN. Phenols, alkaloids and terpenes from medicinal plants with antihypertensive and vasorelaxant activities. A review of natural products as leads to potential therapeutic agents.Nat. Prod. Commun.2013841934578X130080010.1177/1934578X130080043423738474
     [Google Scholar]
/content/journals/chamc/10.2174/0118715257251651231212045407
Loading
Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats
Cardiovasc. Hematol. Agents Med. Chem. 22, 432 (2024); https://doi.org/10.2174/0118715257251651231212045407
/content/journals/chamc/10.2174/0118715257251651231212045407
/content/journals/chamc/10.2174/0118715257251651231212045407
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): ACE-2; antihypertensive; Daphne gnidium (L.); hypertension; receptor-activated calcium channels (ROCCs); vasorelaxant

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test