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The antihypertensive activity of Daphne gnidium was tested.
Daphne gnidium (Thymelaeaceae) is used against hypertension.
The antihypertensive effect of Daphne gnidium was evaluated in this study.
The effect of Daphne gnidium aqueous extract (DGAE, 100 and 180 mg/kg) on blood pressure was evaluated in rats. In addition, the vasorelaxant effect of this extract was also tested.
DGAE lowered blood pressure in hypertensive rats and exhibited vasorelaxant activity. In addition, cumulative concentrations of DGAE induced vasodilatation through receptor-activated calcium channels (ROCCs) without affecting ACE-2.
The aqueous extract of Daphne gnidium exhibits antihypertensive activity and induces vasodilatation via the inhibition of Ca2+ entry.
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