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Volume 3, Issue 1
  • ISSN: 2666-8629
  • E-ISSN: 2666-8637

Abstract

Background and Objectives

Obesity is strongly associated with mood disorders. There is evidence that obesity and mood disorders may be related pathologically. Depression and manic episodes are more common among overweight or obese individuals. Human subjects have reported the restorative effects of probiotic supplementation on neuroendocrine functions. Gut microbiota, neuroendocrine status, and obesity are related. Magnesium enriches the gut microbiota. Based on the association between gut microbiota, magnesium levels, obesity, and neuropsychiatric disorders, we examined the possibility of co-supplementation of probiotics and magnesium in humans.

Methods

For 74 individuals, demographic data, quality of life scores (SF -12), depression, anxiety, and stress scores (DASS-21) were collected, along with body mass index (BMI), waist circumference, and serum cortisol levels. An SPSS analysis was performed.

Results

Both the intervention and control groups experienced significant reductions in depression, anxiety, and stress. A significant improvement in mental health, role-emotional function, and vitality was observed in the probiotic and magnesium supplement group.

Conclusion

Magnesium supplements and probiotics increased vitality (VT) and mental health (MH) and reduced functional impairment from emotional stress (RE). They experienced fewer functional limitations because of physical conditions.

Clinical Trial Registration

IRCT20191127045525N1.

© 2025 Bentham Science Publishers
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2023-10-22
2025-01-24

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/content/journals/cff/10.2174/0126668629257875230920091340
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Effects of Probiotics and Magnesium Co-supplementation on Stress Levels and Quality of Life in Obese Patients with Depressed Mood: A Randomized, Double-blinded Placebo-controlled Clinical Trial
Curr Func Foods 3, E221023222518 (2025); https://doi.org/10.2174/0126668629257875230920091340
/content/journals/cff/10.2174/0126668629257875230920091340
/content/journals/cff/10.2174/0126668629257875230920091340
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  • Article Type:     Research Article
Keyword(s): bipolar disorder; mood disorders; obesity; pathologically; stress scores; Vitality (VT)

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