Diabetes mellitus (DM) is an intricate metabolic disorder marked by persistent hyperglycemia arising from disruptions in glucose metabolism with two main forms type 1 and type 2 involving distinct etiologies affecting β-cell destruction or insulin levels and sensitivity. The islets of Langerhans particularly β-cells and α-cells play a pivotal role in glucose regulation and both DM types lead to severe complications including retinopathy nephropathy and neuropathy Read More

The discovery of antivascular endothelial growth factor medications has resulted in a substantial change in diabetic retinopathy treatment. The most common cause of diabetic retinopathy blindness is Diabetic Macular Edema. The pathophysiology of Diabetic Macular Edema is thought to include the well-known pro-angiogenic and pro-permeability factor vascular endothelial growth factor. Over the past decade drugs that impede the functions of va Read More

BackgroundContrast agents directly cause kidney toxicity in patients who are candidates for percutaneous intervention having cardiovascular disease with type 2 diabetes.AimsThis meta-analysis aims to assess the effects of SGLT2i on renal function in individuals undergoing percutaneous intervention.MethodsThe databases used for the search included Google Scholar PubMed Cochrane Central Registry of Controlled Trials and Scopu Read More

IntroductionPatients with hypertension and diabetes are more susceptible to cardiovascular diseases (CVD) and mortality. This study aimed to evaluate the individual and combined effects of hypertension and diabetes on cardiovascular events and mortality in a Middle Eastern population-based cohort.MethodsFifteen-year follow-up data were collected for 6323 adults aged 35 years and older who were free from CVD at baseline. The subje Read More

BackgroundDiabetes mellitus (DM) arising from pancreatic β-cell dysfunction and disrupted alpha-amylase secretion manifests as hyperglycemia. Synthetic inhibitors of alpha-amylase like acarbose manage glucose but pose adverse effects prompting interest in plant-derived alternatives rich in antioxidants and anti-inflammatory properties.ObjectiveThe current review investigates plant-based alpha-amylase inhibitors exploring their potential therapeutic r Read More

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by chronic hyperglycemia which often co-exists with other metabolic impairments. This condition can damage various tissues and organs resulting in the development of severe complications both microvascular such as retinopathy nephropathy and neuropathy and macrovascular responsible for an increased risk of cardiovascular diseases. Curcumin is the main bi Read More

BackgroundThe global incidence of type 2 diabetes (T2D) persists at epidemic proportions. Early diagnosis and/or preventive efforts are critical to attenuate the multi-systemic clinical manifestation and consequent healthcare burden. Despite enormous strides in the understanding of pathophysiology and on-going therapeutic development effectiveness and access are persistent limitations. Among the greatest challenges the extensive research efforts have n Read More

BackgroundPlants are used in medicine because they are low-cost widely available and have few side effects (compared to pharmacological treatment). Plants have phytocompounds with antidiabetic properties that can be delivered using nanoparticles (NPs).ObjectiveTo describe the antidiabetic properties of green synthesized NPs (GSNPs) and their characterization methods.MethodsThree databases were consulted using the terms “type 2 diabetes mel Read More

AimsThe objective of this study was to investigate the correlation between serum 25 hydroxyvitamin D [25(OH)D] levels and insulin resistance as well as metabolic associated fatty liver disease (MAFLD) in newly diagnosed with type 2 diabetes mellitus (T2DM) patients.MethodsA retrospective analysis was conducted on 491 T2DM patients who were newly diagnosed between January 2017 and August 2022 at Peking University International Hospital. T Read More

ObjectiveThis network meta-analysis [NMA] investigated the efficacy of adjunctive use of subgingivally delivered antimicrobials to non-surgical periodontal therapy [NSPT] in the glycemic control and periodontal pocket depth (PPD) reduction in patients with type 2 diabetes (T2D).MethodsSeven databases grey literature and registry platforms were searched up to February 2024 to identify randomized clinical trials (RCT) fulfilling the eligibility criteria. The r Read More