Atopic dermatitis [AD] a disorder that is on the rise affects about 20% of people globally including children. It is believed that immunological inadequacies pathogenic microorganisms the environment and anomalies in the function of the epidermal barrier interact intricately with the pathophysiology of AD. Studies on the impact of oxidative stress on many skin conditions have been carried out but there aren’t many on AD. Topical corticosteroids and Read More

Background Jaw muscles are essential for chewing and swallowing generating electrical signals measurable through electromyography (EMG). In food science EMG is increasingly being used to link food texture with consumption Objective This study aimed to analyze chewing EMG data using signal processing and machine learning to explore its relationship with sensory evaluation. Methods Participants tasted three gels with identical flavors but different color Read More

Background Radiosensitivity remains an important factor affecting the clinical outcome of radiotherapy for non-small cell lung cancer (NSCLC). Liver kinase B1 (LKB1) as a tumor suppressor is one of the most commonly mutated genes in NSCLC. However the role of LKB1 on radiosensitivity and the possible mechanism have not been elucidated in the NSCLC. In this study we investigated the regulatory function of LKB1 in the radiosensitivity of NSCLC c Read More

Objective Ulcerative colitis (UC) is a chronic non-specific inflammatory disease of the rectum and colon with unknown etiology. A growing number of evidence suggest that the pathogenesis of UC is related to excessive apoptosis and production of inflammatory cytokines. However the functions and molecular mechanisms associated with UC remain unclear. Materials and Methods The in vivo and in vitro models of UC were established in this study. MiRNA Read More

Background The emergence of treatment resistance has hindered the efficacy of targeted therapies used to treat patients with hepatocellular carcinoma (HCC). Objective This study aimed to explore the mechanism of organoids constructed from lenvatinib-resistant HCC cells. Methods Hep3B cell and human HCC organoids were cultured and identified using hematoxylin and eosin staining and Immunohistochemistry. Lenvatinib-sensitive/ resistant Hep3B Read More

Gastrointestinal (GI) cancer is one the most prevalent types of cancer. Despite current chemotherapy's success patients with GI cancer continue to have a dismal outcome. The onset and progression of cancer are caused by alterations and the abnormal expression of several families of genes like tumor-suppressor genes oncogenes and chemotherapy-resistant genes. The final purpose of tumor therapy is to inhibit cellular development by modifyin Read More

Background Hippo signaling regulates the behavior and fate of mesenchymal stem cells (MSCs) which are crucial for the repair and cure of acute respiratory distress syndrome (ARDS). However whether 2-deoxy-D-glucose (2-DG) a specific activator of Hippo signaling would further enhance the reparative effect of MSCs in ARDS remains unclarified. Objective This study aimed to determine whether 2-DG could promote the proliferation differentiation migratio Read More

Nowadays the research of exhaled breath condensate (EBC) analysis is widely discussed in the scientific community. The growing interest in EBC analysis results is related to the ample advantages of non-invasive techniques in healthcare and related fields. In particular EBC analysis can be used to diagnose respiratory diseases monitor the disease’s course during therapy and monitor drug intake and metabolism. This review aims to systematize the ac Read More

Breast cancer is a heterogeneous disease and highly prevalent malignancy affecting women globally. Breast cancer treatments have been demonstrated to elicit significant and long-lasting effects on various aspects of a patient's life including physical emotional social and financial highlighting the need for comprehensive cancer care. Recent research suggests that the composition and activity of the gut microbiota may play a crucial role in anticance Read More

BackgroundDiabetic nephropathy is a progressive kidney disease that frequently results in end-stage renal disorders and is characterized by proteinuria albuminuria decreased filtration and renal fibrosis. Despite the fact that there are a number of therapeutic alternatives available DN continues to be the main contributor to end-stage renal disease. Therefore significant innovation is required to enhance outcomes in DN patients.MethodsInformation was c Read More