Recent Advances in Drug Delivery and Formulation - Online First

Background Endophthalmitis, an inflammatory condition of the intraocular cavity, poses a significant challenge in ophthalmology due to its rapid progression and potential for vision loss. Conventional treatment modalities, such as systemic antibiotics or oral administration, often face limitations in achieving the required therapeutic levels at the target site. Hence, repeated intravitreal injections of antibiotics are current Read More

Breast cancer continues to pose a significant global health challenge, with conventional therapies frequently hindered by resistance mechanisms and undesirable side effects. This review investigates the therapeutic potential of polyphenols—naturally occurring compounds recognized for their antioxidant, anti-inflammatory, and anti-cancer properties—as alternative or complementary treatments for breast cancer. We examine Read More

Nanostructured Lipid Carriers (NLCs) represent a promising advancement in the treatment of breast cancer, addressing the significant challenges posed by conventional chemotherapy, such as poor drug solubility, short half-lives, and high toxicity. This review delves into the potential of NLCs to overcome these limitations, highlighting their unique structure comprising a solid and lipid liquid core stabilized by surfactants. By exami Read More

Background Genistein (GEN) shows significant anticancer potential, particularly against prostate cancer. However, its clinical application is limited by poor water solubility, rapid metabolism and excretion, low bioavailability, and lack of targeted delivery to cancer cells, hindering its effectiveness as a chemopreventive or therapeutic agent. Objective In this study, poly-ε-caprolactone (PCL) nanoparticles incorporating polyvinyl alco Read More