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image of A Comprehensive Review of Nanostructured Lipid Carriers: Innovations and Applications in Breast Cancer Treatment

Abstract

Nanostructured Lipid Carriers (NLCs) represent a promising advancement in the treatment of breast cancer, addressing the significant challenges posed by conventional chemotherapy, such as poor drug solubility, short half-lives, and high toxicity. This review delves into the potential of NLCs to overcome these limitations, highlighting their unique structure comprising a solid and lipid liquid core stabilized by surfactants. By examining diverse lipid blends used in the preparation of NLCs, the article emphasizes their suitability for targeted drug delivery. Various facets of NLC configuration, categorization, composition, and formulation approaches are systematically explored to provide a comprehensive understanding of their attributes. The findings reveal that NLCs possess a high capacity for lipophilic drugs and offer advantages over traditional lipid-based nanocarriers. The review underscores the pivotal role of NLCs in enhancing drug delivery efficiency for breast cancer therapy while minimizing systemic toxicity. Conclusively, this review positions NLCs as a key player in the evolution of drug delivery systems for breast cancer treatment, providing a detailed outlook on their transformative potential and contributing to a nuanced understanding of their significance in advancing the field of breast cancer treatment.

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2024-12-09
2025-01-20

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References

  1. Harwansh R.K. Bahadur S. Deshmukh R. Rahman M.A. Exciting potential of nanoparticlized lipidic system for effective treatment of breast cancer and clinical updates: A translational prospective. Curr. Pharm. Des. 2020 26 11 1191 1205 10.2174/1381612826666200131101156 32003686
    [Google Scholar]
  2. Gadag S. Sinha S. Nayak Y. Garg S. Nayak U.Y. Combination therapy and nanoparticulate systems: Smart approaches for the effective treatment of breast cancer. Pharmaceutics 2020 12 6 524 10.3390/pharmaceutics12060524 32521684
    [Google Scholar]
  3. Kumar M. Rajnikanth P.S. A mini-review on HER2 positive breast cancer and its metastasis: Resistance and treatment strategies. Curr. Nanomed. 2020 10 1 36 47 10.2174/2468187310666191223141038
    [Google Scholar]
  4. Nurgali K. Jagoe R.T. Abalo R. Editorial: Adverse effects of cancer chemotherapy: Anything new to improve tolerance and reduce sequelae? Front. Pharmacol. 2018 9 MAR 245 10.3389/fphar.2018.00245 29623040
    [Google Scholar]
  5. Narang J.K. Khan S. Baboota S. Ali J. Khan S. Narang R. Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic drugs. Int. J. Pharm. Investig. 2015 5 4 182 191 10.4103/2230‑973X.167661 26682188
    [Google Scholar]
  6. Sledge G.W. Mamounas E.P. Hortobagyi G.N. Burstein H.J. Goodwin P.J. Wolff A.C. Past, present, and future challenges in breast cancer treatment. J. Clin. Oncol. 2014 32 19 1979 1986 10.1200/JCO.2014.55.4139 24888802
    [Google Scholar]
  7. DeVita V.T. Jr Chu E. A history of cancer chemotherapy. Cancer Res. 2008 68 21 8643 8653 10.1158/0008‑5472.CAN‑07‑6611 18974103
    [Google Scholar]
  8. Chabner B.A. Roberts T.G. Jr Chemotherapy and the war on cancer. Nat. Rev. Cancer 2005 5 1 65 72 10.1038/nrc1529 15630416
    [Google Scholar]
  9. Belachew S.A. Erku D.A. Mekuria A.B. Gebresillassie B.M. Pattern of chemotherapy-related adverse effects among adult cancer patients treated at Gondar University Referral Hospital, Ethiopia: A cross-sectional study. Drug Healthc. Patient Saf. 2016 8 83 90 10.2147/DHPS.S116924 27994485
    [Google Scholar]
  10. Mehnert W. Mader K. Advances in the cognitive neuroscience of neurodevelopmental disorders: Views from child psychiatry and medical genetics. Neurodev Disord. 2020 47 165 196
    [Google Scholar]
  11. de Jong W.H. Borm P.J.A. Drug delivery and nanoparticles: Applications and hazards. Int. J. Nanomedicine 2008 3 2 133 149 10.2147/IJN.S596 18686775
    [Google Scholar]
  12. Shidhaye S. Vaidya R. Sutar S. Patwardhan A. Kadam V. Solid lipid nanoparticles and nanostructured lipid carriers--innovative generations of solid lipid carriers. Curr. Drug Deliv. 2008 5 4 324 331 10.2174/156720108785915087 18855604
    [Google Scholar]
  13. Mugundhan S.L. Mohan M. Nanoscale strides: Exploring innovative therapies for breast cancer treatment. RSC Advances 2024 14 20 14017 14040 10.1039/D4RA02639J 38686289
    [Google Scholar]
  14. Barenholz Y.C. Doxil® — The first FDA-approved nano-drug: Lessons learned. J. Control. Release 2012 160 2 117 134 10.1016/j.jconrel.2012.03.020 22484195
    [Google Scholar]
  15. A study of BIND-014 given to patients with advanced or metastatic cancer Patent NCT01300533, 2016
  16. Carpin L.B. Bickford L.R. Agollah G. Yu T.K. Schiff R. Li Y. Drezek R.A. Immunoconjugated gold nanoshell-mediated photothermal ablation of trastuzumab-resistant breast cancer cells. Breast Cancer Res. Treat. 2011 125 1 27 34 10.1007/s10549‑010‑0811‑5 20217215
    [Google Scholar]
  17. Chadar R. Afzal O. Alqahtani S.M. Kesharwani P. Carbon nanotubes as an emerging nanocarrier for the delivery of doxorubicin for improved chemotherapy. Colloids Surf. B Biointerfaces 2021 208 May 112044 10.1016/j.colsurfb.2021.112044 34419810
    [Google Scholar]
  18. Oddone N. Lecot N. Fernández M. Rodriguez-Haralambides A. Cabral P. Cerecetto H. Benech J.C. In vitro and in vivo uptake studies of PAMAM G4.5 dendrimers in breast cancer. J. Nanobiotechnology 2016 14 1 45 10.1186/s12951‑016‑0197‑6 27297021
    [Google Scholar]
  19. Tyagi N. Gupta P. Khan Z. Neupane Y.R. Mangla B. Mehra N. Ralli T. Alhalmi A. Ali A. Al Kamaly O. Saleh A. Nasr F.A. Kohli K. Superparamagnetic iron-oxide nanoparticles synthesized via green chemistry for the potential treatment of breast Cancer. Molecules 2023 28 5 2343 10.3390/molecules28052343 36903587
    [Google Scholar]
  20. Omidian H. Wilson R.L. Cubeddu L.X. Quantum dot research in breast cancer: Challenges and prospects. Materials (Basel) 2024 17 9 2152 10.3390/ma17092152 38730959
    [Google Scholar]
  21. Mozafarinia M. Karimi S. Farrokhnia M. Esfandiari J. In vitro breast cancer targeting using Trastuzumab-conjugated mesoporous silica nanoparticles: Towards the new strategy for decreasing size and high drug loading capacity for drug delivery purposes in MSN synthesis. Microporous Mesoporous Mater. 2021 316 January 110950 [Internet]. 10.1016/j.micromeso.2021.110950
    [Google Scholar]
  22. Yuan S.J. Xu Y.H. Wang C. An H.C. Xu H.Z. Li K. Komatsu N. Zhao L. Chen X. Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer. J. Nanobiotechnology 2019 17 1 110 10.1186/s12951‑019‑0541‑8 31623629
    [Google Scholar]
  23. Kristi L. Stringer, Bulent Turan, Lisa McCormick, Modupeoluwa Durojaiye, Laura Nyblade, Mirjam-Colette Kempf, Bronwen Lichtenstein and JMT. A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity. Physiol. Behav. 2017 176 3 139 148
    [Google Scholar]
  24. Chen S. Liu W. Wan J. Cheng X. Gu C. Zhou H. Chen S. Zhao X. Tang Y. Yang X. Preparation of Coenzyme Q10 nanostructured lipid carriers for epidermal targeting with high-pressure microfluidics technique. Drug Dev. Ind. Pharm. 2013 39 1 20 28 10.3109/03639045.2011.650648 23116283
    [Google Scholar]
  25. Javed S. Mangla B. Almoshari Y. Sultan M.H. Ahsan W. Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications in drug delivery. Nanotechnol. Rev. 2022 11 1 1744 1777 10.1515/ntrev‑2022‑0109
    [Google Scholar]
  26. Joun I Nixdorf S Advances in lipid-based nanocarriers for breast cancer metastasis treatment. Front Med Technol. 2020 4 893056
    [Google Scholar]
  27. Müller R.H. Radtke M. Wissing S.A. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev. 2002 54 Suppl. 1 S131 S155 10.1016/S0169‑409X(02)00118‑7 12460720
    [Google Scholar]
  28. Kasongo K.W. Jansch M. Müller R.H. Walker R.B. Evaluation of the in vitro differential protein adsorption patterns of didanosine-loaded nanostructured lipid carriers (NLCs) for potential targeting to the brain. J. Liposome Res. 2011 21 3 245 254 10.3109/08982104.2010.539186 21174528
    [Google Scholar]
  29. Nair R. Kumar K.S.A. Priya K.V. Sevukarajan M. Recent advances in solid lipid nanoparticle based drug delivery systems. J Biomed Sci Res. 2011 3 2 368 384
    [Google Scholar]
  30. Radtke M. Souto E.B. Müller R.H. Nanostructured lipid carriers: A novel generation of solid lipid drug carriers. Pharm Technol Eur. 2005 17 4 45 50
    [Google Scholar]
  31. Sp P.A. Nanostructured lipid carriers as a drug carrier. J Pharm Nanotechnol. 2016 4 68 74
    [Google Scholar]
  32. Dubey A. Prabhu P. Kamath J.V. Nano structured lipid carriers: A novel topical drug delivery system. Int. J. Pharm. Tech. Res. 2012 4 2 705 714
    [Google Scholar]
  33. Purohit D.K. Nandgude T.D. Poddar S.S. Nano-lipid carriers for topical application: Current scenario. Asian J. Pharm. 2016 10 1 S1 S9
    [Google Scholar]
  34. Sharma A. Baldi A. Nanostructured lipid carriers : A review journal. J. Dev. Drugs 2018 7 2 1 12
    [Google Scholar]
  35. Charcosset C. El-Harati A. Fessi H. Preparation of solid lipid nanoparticles using a membrane contactor. J. Control. Release 2005 108 1 112 120 10.1016/j.jconrel.2005.07.023 16169111
    [Google Scholar]
  36. Haider M. Abdin S.M. Kamal L. Orive G. Nanostructured lipid carriers for delivery of chemotherapeutics: A review. Pharmaceutics 2020 12 3 288 10.3390/pharmaceutics12030288 32210127
    [Google Scholar]
  37. Waheed I. Ali A. Tabassum H. Khatoon N. Lai W.F. Zhou X. Lipid-based nanoparticles as drug delivery carriers for cancer therapy. Front. Oncol. 2024 14 1296091 10.3389/fonc.2024.1296091 38660132
    [Google Scholar]
  38. Müller R.H. Radtke M. Wissing S.A. Nanostructured lipid matrices for improved microencapsulation of drugs. Int. J. Pharm. 2002 242 1-2 121 128 10.1016/S0378‑5173(02)00180‑1 12176234
    [Google Scholar]
  39. Jenning V. Gohla S.H. Encapsulation of retinoids in solid lipid nanoparticles (SLN). J. Microencapsul. 2001 18 2 149 158 10.1080/02652040010000361 11253932
    [Google Scholar]
  40. Khosa A. Reddi S. Saha R.N. Nanostructured lipid carriers for site-specific drug delivery. Biomed. Pharmacother. 2018 103 February 598 613 10.1016/j.biopha.2018.04.055 29677547
    [Google Scholar]
  41. Abdelbary G. Haider M. In vitro characterization and growth inhibition effect of nanostructured lipid carriers for controlled delivery of methotrexate. Pharm. Dev. Technol. 2013 18 5 1159 1168 10.3109/10837450.2011.614251 21958084
    [Google Scholar]
  42. Liu D. Liu Z. Wang L. Zhang C. Zhang N. Nanostructured lipid carriers as novel carrier for parenteral delivery of docetaxel. Colloids Surf. B Biointerfaces 2011 85 2 262 269 10.1016/j.colsurfb.2011.02.038 21435845
    [Google Scholar]
  43. Ding X. Xu X. Zhao Y. Zhang L. Yu Y. Huang F. Yin D. Huang H. Tumor targeted nanostructured lipid carrier co-delivering paclitaxel and indocyanine green for laser triggered synergetic therapy of cancer. RSC Advances 2017 7 56 35086 35095 [Internet]. 10.1039/C7RA06119F
    [Google Scholar]
  44. Zhang X.G. Miao J. Dai Y.Q. Du Y.Z. Yuan H. Hu F.Q. Reversal activity of nanostructured lipid carriers loading cytotoxic drug in multi-drug resistant cancer cells. Int. J. Pharm. 2008 361 1-2 239 244 10.1016/j.ijpharm.2008.06.002 18586075
    [Google Scholar]
  45. Sun M. Nie S. Pan X. Zhang R. Fan Z. Wang S. Quercetin-nanostructured lipid carriers: Characteristics and anti-breast cancer activities in vitro. Colloids Surf. B Biointerfaces 2014 113 15 24 10.1016/j.colsurfb.2013.08.032 24060926
    [Google Scholar]
  46. Chen Y. Pan L. Jiang M. Li D. Jin L. Nanostructured lipid carriers enhance the bioavailability and brain cancer inhibitory efficacy of curcumin both in vitro and in vivo. Drug Deliv. 2016 23 4 1383 1392 10.3109/10717544.2015.1049719 26066035
    [Google Scholar]
  47. Bond M.L. Diana P. Martorana A. Cirrincione G. Nanostructured lipid carriers-containing anticancer compounds : Preparation, characterization, and Cytotoxicity studies 2007 14 61 67
    [Google Scholar]
  48. Wang Y. Zhang H. Hao J. Li B. Li M. Xiuwen W. Lung cancer combination therapy: Co-delivery of paclitaxel and doxorubicin by nanostructured lipid carriers for synergistic effect. Drug Deliv. 2016 23 4 1398 1403 10.3109/10717544.2015.1055619 26079530
    [Google Scholar]
  49. Fang Y.P. Lin Y.K. Su Y.H. Fang J.Y. Tryptanthrin-loaded nanoparticles for delivery into cultured human breast cancer cells, MCF7: The effects of solid lipid/liquid lipid ratios in the inner core. Chem. Pharm. Bull. (Tokyo) 2011 59 2 266 271 10.1248/cpb.59.266 21297310
    [Google Scholar]
  50. Sabzichi M. Samadi N. Mohammadian J. Hamishehkar H. Akbarzadeh M. Molavi O. Sustained release of melatonin: A novel approach in elevating efficacy of tamoxifen in breast cancer treatment. Colloids Surf. B Biointerfaces 2016 145 64 71 10.1016/j.colsurfb.2016.04.042 27137804
    [Google Scholar]
  51. Abdolahpour S. Toliyat T. Omidfar K. Modjtahedi H. Wong A.J. Rasaee M.J. Kashanian S. Paknejad M. Targeted delivery of doxorubicin into tumor cells by nanostructured lipid carriers conjugated to anti-EGFRvIII monoclonal antibody. Artif. Cells Nanomed. Biotechnol. 2018 46 1 89 94 10.1080/21691401.2017.1296847 28296511
    [Google Scholar]
  52. Sjöström B. Westesen K. Bergenståhl B. Preparation of submicron drug particles in lecithin-stabilized o/w emulsions. Int. J. Pharm. 1993 94 1-3 89 101 10.1016/0378‑5173(93)90013‑6
    [Google Scholar]
  53. Souto E.B. Müller R.H. Investigation of the factors influencing the incorporation of clotrimazole in SLN and NLC prepared by hot high-pressure homogenization. J. Microencapsul. 2006 23 4 377 388 10.1080/02652040500435295 16854814
    [Google Scholar]
  54. Cirri M. Maestrini L. Maestrelli F. Mennini N. Mura P. Ghelardini C. Di Cesare Mannelli L. Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy. Drug Deliv. 2018 25 1 1910 1921 10.1080/10717544.2018.1529209 30451015
    [Google Scholar]
  55. Carvajal-Vidal P. Fábrega M.J. Espina M. Calpena A.C. García M.L. Development of Halobetasol-loaded nanostructured lipid carrier for dermal administration: Optimization, physicochemical and biopharmaceutical behavior, and therapeutic efficacy. Nanomedicine. 2019 102026
    [Google Scholar]
  56. Fang J.Y. Fang C.L. Liu C.H. Su Y.H. Lipid nanoparticles as vehicles for topical psoralen delivery: Solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur. J. Pharm. Biopharm. 2008 70 2 633 640 10.1016/j.ejpb.2008.05.008 18577447
    [Google Scholar]
  57. Cirri M. Bragagni M. Mennini N. Mura P. Development of a new delivery system consisting in “drug – in cyclodextrin – in nanostructured lipid carriers” for ketoprofen topical delivery. Eur. J. Pharm. Biopharm. 2012 80 1 46 53 10.1016/j.ejpb.2011.07.015 21839833
    [Google Scholar]
  58. Beloqui A. Solinís M.Á. Rodríguez-Gascón A. Almeida A.J. Préat V. Nanostructured lipid carriers: Promising drug delivery systems for future clinics. Nanomedicine 2016 12 1 143 161 10.1016/j.nano.2015.09.004 26410277
    [Google Scholar]
  59. Fang C.L. Al-Suwayeh S.A. Fang J.Y. Nanostructured lipid carriers (NLCs) for drug delivery and targeting. Recent Pat. Nanotechnol. 2013 7 1 41 55 10.2174/187221013804484827 22946628
    [Google Scholar]
  60. Das S. Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech 2011 12 1 62 76 10.1208/s12249‑010‑9563‑0 21174180
    [Google Scholar]
  61. Lim W. Rajinikanth P.S. Mallikarjun C. Kang Y.B. Formulation and delivery of itraconazole to the brain using a nanolipid carrier system. Int. J. Nanomedicine 2014 9 1 2117 2126 10.2147/IJN.S57565 24833900
    [Google Scholar]
  62. Liu Y. Wang L. Zhao Y. He M. Zhang X. Niu M. Feng N. Nanostructured lipid carriers versus microemulsions for delivery of the poorly water-soluble drug luteolin. Int. J. Pharm. 2014 476 1-2 169 177 10.1016/j.ijpharm.2014.09.052 25280882
    [Google Scholar]
  63. El-Helw A.R. Fahmy U. Improvement of fluvastatin bioavailability by loading on nanostructured lipid carriers. Int. J. Nanomedicine 2015 10 5797 5804 10.2147/IJN.S91556 26396513
    [Google Scholar]
  64. Shah N.V. Seth A.K. Balaraman R. Aundhia C.J. Maheshwari R.A. Parmar G.R. Nanostructured lipid carriers for oral bioavailability enhancement of raloxifene: Design and in vivo study. J. Adv. Res. 2016 7 3 423 434 10.1016/j.jare.2016.03.002 27222747
    [Google Scholar]
  65. Iqbal M.A. Md S. Sahni J.K. Baboota S. Dang S. Ali J. Nanostructured lipid carriers system: Recent advances in drug delivery. J. Drug Target. 2012 20 10 813 830 10.3109/1061186X.2012.716845 22931500
    [Google Scholar]
  66. Zhang K. Lv S. Li X. Feng Y. Li X. Liu L. Li S. Li Y. Preparation, characterization, and in vivo pharmacokinetics of nanostructured lipid carriers loaded with oleanolic acid and gentiopicrin. Int. J. Nanomedicine 2013 8 3227 3239 10.2147/IJN.S45031 24009420
    [Google Scholar]
  67. Joshi M. Patravale V. Formulation and evaluation of nanostructured lipid carrier (NLC)-based gel of Valdecoxib. Drug Dev. Ind. Pharm. 2006 32 8 911 918 10.1080/03639040600814676 16954103
    [Google Scholar]
  68. Bhagurkar A.M. Repka M.A. Murthy S.N. A novel approach for the development of a nanostructured lipid carrier formulation by Hot-Melt extrusion technology. J. Pharm. Sci. 2017 106 4 1085 1091 10.1016/j.xphs.2016.12.015 28040458
    [Google Scholar]
  69. Kaur P. Mishra V. Shunmugaperumal T. Goyal A.K. Ghosh G. Rath G. Inhalable spray dried lipidnanoparticles for the co-delivery of paclitaxel and doxorubicin in lung cancer. J. Drug Deliv. Sci. Technol. 2020 56 101502 [Internet]. 10.1016/j.jddst.2020.101502
    [Google Scholar]
  70. Zhang X. Pan W. Gan L. Zhu C. Gan Y. Nie S. Preparation of a dispersible PEGylate nanostructured lipid carriers (NLC) loaded with 10-hydroxycamptothecin by spray-drying. Chem. Pharm. Bull. (Tokyo) 2008 56 12 1645 1650 10.1248/cpb.56.1645 19043233
    [Google Scholar]
  71. Xia D. Shrestha N. van de Streek J. Mu H. Yang M. Spray drying of fenofibrate loaded nanostructured lipid carriers. Asian J Pharm Sci. 2016 11 4 507 515 10.1016/j.ajps.2016.01.001
    [Google Scholar]
  72. Zhong Q. Zhang L. Nanoparticles fabricated from bulk solid lipids: Preparation, properties, and potential food applications. Adv. Colloid Interface Sci. 2019 273 102033 10.1016/j.cis.2019.102033 31614266
    [Google Scholar]
  73. Lababidi N. Sigal V. Koenneke A. Schwarzkopf K. Manz A. Schneider M. Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration. Beilstein J. Nanotechnol. 2019 10 2280 2293 10.3762/bjnano.10.220 31807413
    [Google Scholar]
  74. Garg S. Heuck G. Ip S. Ramsay E. Microfluidics: A transformational tool for nanomedicine development and production. J. Drug Target. 2016 24 9 821 835 10.1080/1061186X.2016.1198354 27492254
    [Google Scholar]
  75. Aliofkhazraei M. Handbook of nanoparticles. Springer Cham 2015 1 1426 10.1007/978‑3‑319‑13188‑7
    [Google Scholar]
  76. Peer D. Karp J.M. Hong S. Farokhzad O.C. Margalit R. Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2007 2 12 751 760 10.1038/nnano.2007.387 18654426
    [Google Scholar]
  77. Danhier F. Feron O. Préat V. To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J. Control. Release 2010 148 2 135 146 10.1016/j.jconrel.2010.08.027 20797419
    [Google Scholar]
  78. Teeranachaideekul V. Souto E.B. Junyaprasert V.B. Müller R.H. Cetyl palmitate-based NLC for topical delivery of Coenzyme Q10 – Development, physicochemical characterization and in vitro release studies. Eur. J. Pharm. Biopharm. 2007 67 1 141 148 10.1016/j.ejpb.2007.01.015 17346953
    [Google Scholar]
  79. Moghimi S.M. Hunter A.C. Andresen T.L. Factors controlling nanoparticle pharmacokinetics: An integrated analysis and perspective. Annu. Rev. Pharmacol. Toxicol. 2012 52 1 481 503 10.1146/annurev‑pharmtox‑010611‑134623 22035254
    [Google Scholar]
  80. Truong N.P. Whittaker M.R. Mak C.W. Davis T.P. The importance of nanoparticle shape in cancer drug delivery. Expert Opin. Drug Deliv. 2015 12 1 129 142 10.1517/17425247.2014.950564 25138827
    [Google Scholar]
  81. Tamjidi F. Shahedi M. Varshosaz J. Nasirpour A. Nanostructured lipid carriers (NLC): A potential delivery system for bioactive food molecules Innovative Food Science and Emerging Technologies Elsevier 2013 19 29 43 10.1016/j.ifset.2013.03.002
    [Google Scholar]
  82. Xu R. Progress in nanoparticles characterization: Sizing and zeta potential measurement. Particuology 2008 6 2 112 115 10.1016/j.partic.2007.12.002
    [Google Scholar]
  83. Gonzalez-Mira E. Egea M.A. Souto E.B. Calpena A.C. García M.L. Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery. Nanotechnology 2011 22 4 045101 10.1088/0957‑4484/22/4/045101 21169662
    [Google Scholar]
  84. Parveen S. Sahoo S.K. Polymeric nanoparticles for cancer therapy. J. Drug Target. 2008 16 2 108 123 10.1080/10611860701794353 18274932
    [Google Scholar]
  85. How C.W. Rasedee A. Manickam S. Rosli R. Tamoxifen-loaded nanostructured lipid carrier as a drug delivery system: Characterization, stability assessment and cytotoxicity. Colloids Surf. B Biointerfaces 2013 112 393 399 10.1016/j.colsurfb.2013.08.009 24036474
    [Google Scholar]
  86. Hu F.Q. Jiang S.P. Du Y.Z. Yuan H. Ye Y.Q. Zeng S. Preparation and characteristics of monostearin nanostructured lipid carriers. Int. J. Pharm. 2006 314 1 83 89 10.1016/j.ijpharm.2006.01.040 16563671
    [Google Scholar]
  87. Han F. Li S. Yin R. Liu H. Xu L. Effect of surfactants on the formation and characterization of a new type of colloidal drug delivery system: Nanostructured lipid carriers. Colloids Surf. A Physicochem. Eng. Asp. 2008 315 1-3 210 216 10.1016/j.colsurfa.2007.08.005
    [Google Scholar]
  88. Bunjes H. Westesen K. Koch M.H.J. Crystallization tendency and polymorphic transitions in triglyceride nanoparticles. Int. J. Pharm. 1996 129 1-2 159 173 10.1016/0378‑5173(95)04286‑5
    [Google Scholar]
  89. Sanjula B. Shah F.M. Javed A. Alka A. Effect of poloxamer 188 on lymphatic uptake of carvedilol-loaded solid lipid nanoparticles for bioavailability enhancement. J. Drug Target. 2009 17 3 249 256 10.1080/10611860902718672 19255893
    [Google Scholar]
  90. Jenning V. Gohla S. Comparison of wax and glyceride solid lipid nanoparticles (SLN®). Int. J. Pharm. 2000 196 2 219 222 10.1016/S0378‑5173(99)00426‑3 10699722
    [Google Scholar]
  91. Teeranachaideekul V. Müller R. Junyaprasert V. Encapsulation of ascorbyl palmitate in nanostructured lipid carriers (NLC)—Effects of formulation parameters on physicochemical stability. Int. J. Pharm. 2007 340 1-2 198 206 10.1016/j.ijpharm.2007.03.022 17482778
    [Google Scholar]
  92. Jiang H. Pei L. Liu N. Li J. Li Z. Zhang S. Etoposide-loaded nanostructured lipid carriers for gastric cancer therapy. Drug Deliv. 2016 23 4 1379 1382 10.3109/10717544.2015.1048491 26162024
    [Google Scholar]
  93. Emami J. Yousefian H. Sadeghi H. Targeted nanostructured lipid carrier for brain delivery of artemisinin: Design, preparation, characterization, optimization and cell toxicity. J. Pharm. Pharm. Sci. 2018 21 1s 225s 241s 10.18433/jpps30117 30266137
    [Google Scholar]
  94. Sue Lee C. Koo J. A review of acitretin, a systemic retinoid for the treatment of psoriasis. Expert Opin. Pharmacother. 2005 6 10 1725 1734 10.1517/14656566.6.10.1725 16086658
    [Google Scholar]
  95. Liu D. Liu F. Liu Z. Wang L. Zhang N. Tumor specific delivery and therapy by double-targeted nanostructured lipid carriers with anti-VEGFR-2 antibody. Mol. Pharm. 2011 8 6 2291 2301 10.1021/mp200402e 21923159
    [Google Scholar]
  96. Castelli F. Puglia C. Sarpietro M.G. Rizza L. Bonina F. Characterization of indomethacin-loaded lipid nanoparticles by differential scanning calorimetry. Int. J. Pharm. 2005 304 1-2 231 238 10.1016/j.ijpharm.2005.08.011 16188405
    [Google Scholar]
  97. zur Mühlen A. Schwarz C. Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery – Drug release and release mechanism. Eur. J. Pharm. Biopharm. 1998 45 2 149 155 10.1016/S0939‑6411(97)00150‑1 9704911
    [Google Scholar]
  98. Inoue K. Yuasa H. Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy. Drug Metab. Pharmacokinet. 2014 29 1 12 19 10.2133/dmpk.DMPK‑13‑RV‑119 24284432
    [Google Scholar]
  99. Callen J.P. Kulp-Shorten C.L. Methotrexate Comprehensive Dermatologic Drug Therapy Elsevier Amsterdam, The Netherlands 2021 e5 156 168
    [Google Scholar]
  100. Chand P. Kumar H. Badduri N. Gupta N.V. Bettada V.G. Madhunapantula S.V. Kesharwani S.S. Dey S. Jain V. Design and evaluation of cabazitaxel loaded NLCs against breast cancer cell lines. Colloids Surf. B Biointerfaces 2021 199 December 111535 10.1016/j.colsurfb.2020.111535 33360926
    [Google Scholar]
  101. Chen J. Chen H. Cui S. Xue B. Tian J. Achilefu S. Gu Y. Glucosamine derivative modified nanostructured lipid carriers for targeted tumor delivery. J. Mater. Chem. 2012 22 12 5770 5783 10.1039/c2jm15830b
    [Google Scholar]
  102. Ucar E. Teksoz S. Ichedef C. Kilcar A.Y. Medine E.I. Ari K. Parlak Y. Sayit Bilgin B.E. Unak P. Synthesis, characterization and radiolabeling of folic acid modified nanostructured lipid carriers as a contrast agent and drug delivery system. Appl. Radiat. Isot. 2017 119 72 79 10.1016/j.apradiso.2016.11.002 27866122
    [Google Scholar]
  103. Gao X. Zhang J. Xu Q. Huang Z. Wang Y. Shen Q. Hyaluronic acid-coated cationic nanostructured lipid carriers for oral vincristine sulfate delivery. Drug Dev. Ind. Pharm. 2017 43 4 661 667 10.1080/03639045.2016.1275671 28043185
    [Google Scholar]
  104. Mussi S.V. Sawant R. Perche F. Oliveira M.C. Azevedo R.B. Ferreira L.A.M. Torchilin V.P. Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. Pharm. Res. 2014 31 8 1882 1892 10.1007/s11095‑013‑1290‑2 24522814
    [Google Scholar]
  105. Fernandes R.S. Silva J.O. Monteiro L.O.F. Leite E.A. Cassali G.D. Rubello D. Cardoso V.N. Ferreira L.A.M. Oliveira M.C. de Barros A.L.B. Doxorubicin-loaded nanocarriers: A comparative study of liposome and nanostructured lipid carrier as alternatives for cancer therapy. Biomed. Pharmacother. 2016 84 252 257 10.1016/j.biopha.2016.09.032 27664949
    [Google Scholar]
  106. Fernandes R.S. Silva J.O. Mussi S.V. Lopes S.C.A. Leite E.A. Cassali G.D. Cardoso V.N. Townsend D.M. Colletti P.M. Ferreira L.A.M. Rubello D. de Barros A.L.B. Nanostructured lipid carrier co-loaded with Doxorubicin and Docosahexaenoic acid as a theranostic agent: Evaluation of biodistribution and antitumor activity in experimental model. Mol. Imaging Biol. 2018 20 3 437 447 10.1007/s11307‑017‑1133‑3 29043471
    [Google Scholar]
  107. Fernandes R.S. Silva J.O. Seabra H.A. Oliveira M.S. Carregal V.M. Vilela J.M.C. Andrade M.S. Townsend D.M. Colletti P.M. Leite E.A. Cardoso V.N. Ferreira L.A.M. Rubello D. Barros A.L.B. α- Tocopherol succinate loaded nano-structed lipid carriers improves antitumor activity of doxorubicin in breast cancer models in vivo. Biomed. Pharmacother. 2018 103 April 1348 1354 10.1016/j.biopha.2018.04.139 29864917
    [Google Scholar]
  108. Li W. Fu J. Ding Y. Liu D. Jia N. Chen D. Hu H. Low density lipoprotein-inspired nanostructured lipid nanoparticles containing pro-doxorubicin to enhance tumor-targeted therapeutic efficiency. Acta Biomater. 2019 96 456 467 10.1016/j.actbio.2019.06.051 31260821
    [Google Scholar]
  109. Lages E.B. Fernandes R.S. Silva J.O. de Souza Â.M. Cassali G.D. de Barros A.L.B. Miranda Ferreira L.A. Co-delivery of doxorubicin, docosahexaenoic acid, and α-tocopherol succinate by nanostructured lipid carriers has a synergistic effect to enhance antitumor activity and reduce toxicity. Biomed. Pharmacother. 2020 132 October 110876 10.1016/j.biopha.2020.110876 33113428
    [Google Scholar]
  110. Deng C. Jia M. Wei G. Tan T. Fu Y. Gao H. Sun X. Zhang Q. Gong T. Zhang Z. Inducing optimal antitumor immune response through Coadministering iRGD with Pirarubicin loaded nanostructured lipid carriers for breast cancer therapy. Mol. Pharm. 2017 14 1 296 309 10.1021/acs.molpharmaceut.6b00932 27936775
    [Google Scholar]
  111. Di H. Wu H. Gao Y. Li W. Zou D. Dong C. Doxorubicin- and cisplatin-loaded nanostructured lipid carriers for breast cancer combination chemotherapy. Drug Dev. Ind. Pharm. 2016 42 12 2038 2043 10.1080/03639045.2016.1190743 27184819
    [Google Scholar]
  112. Liu Q. Li J. Pu G. Zhang F. Liu H. Zhang Y. Co-delivery of baicalein and doxorubicin by hyaluronic acid decorated nanostructured lipid carriers for breast cancer therapy. Drug Deliv. 2016 23 4 1364 1368 10.3109/10717544.2015.1031295 25874959
    [Google Scholar]
  113. Borges G.S.M. Silva J.O. Fernandes R.S. de Souza Â.M. Cassali G.D. Yoshida M.I. Leite E.A. de Barros A.L.B. Ferreira L.A.M. Sclareol is a potent enhancer of doxorubicin: Evaluation of the free combination and co-loaded nanostructured lipid carriers against breast cancer. Life Sci. 2019 232 July 116678 10.1016/j.lfs.2019.116678 31344429
    [Google Scholar]
  114. Li X. Jia X. Niu H. Nanostructured lipid carriers co-delivering lapachone and doxorubicin for overcoming multidrug resistance in breast cancer therapy. Int. J. Nanomedicine 2018 13 4107 4119 10.2147/IJN.S163929 30034236
    [Google Scholar]
  115. Wang K. Zhang J. de Sousa Júnior W.T. da Silva V.C.M. Rodrigues M.C. Morais J.A.V. Jiang C. Longo J.P.F. Azevedo R.B. Muehlmann L.A. A xanthene derivative, free or associated to nanoparticles, as a new potential agent for anticancer photodynamic therapy. J. Biomater. Sci. Polym. Ed. 2020 31 15 1977 1993 10.1080/09205063.2020.1788370 32589525
    [Google Scholar]
  116. Oshiro-Junior JA Sato MR Boni FI Santos KLM de Oliveira KT de Freitas LM Phthalocyanine-loaded nanostructured lipid carriers functionalized with folic acid for photodynamic therapy. Mater Sci Eng C Mater Biol Appl 2020 108 110462 10.1016/j.msec.2019.110462
    [Google Scholar]
  117. Li H. Wang K. Yang X. Zhou Y. Ping Q. Oupicky D. Sun M. Dual-function nanostructured lipid carriers to deliver IR780 for breast cancer treatment: Anti-metastatic and photothermal anti-tumor therapy. Acta Biomater. 2017 53 399 413 10.1016/j.actbio.2017.01.070 28159715
    [Google Scholar]
  118. Zhang Q. Zhao J. Hu H. Yan Y. Hu X. Zhou K. Xiao S. Zhang Y. Feng N. Construction and in vitro and in vivo evaluation of folic acid-modified nanostructured lipid carriers loaded with paclitaxel and chlorin e6. Int. J. Pharm. 2019 569 118595 10.1016/j.ijpharm.2019.118595 31394189
    [Google Scholar]
/content/journals/raddf/10.2174/0126673878313086241031154146
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A Comprehensive Review of Nanostructured Lipid Carriers: Innovations and Applications in Breast Cancer Treatment
Bentham Science Publishers ; https://doi.org/10.2174/0126673878313086241031154146
/content/journals/raddf/10.2174/0126673878313086241031154146
/content/journals/raddf/10.2174/0126673878313086241031154146
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  • Article Type:     Review Article
Keywords: chemotherapy ; nanostructured lipid carriers ; breast cancer treatment ; drug delivery systems ; Antineoplastic agents ; targeted drug delivery

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