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2000
Volume 19, Issue 2
  • ISSN: 2667-3878
  • E-ISSN: 2667-3886

Abstract

Introduction

Medicinal plants like and have gained attention for their potential in wound healing including antimicrobial and antioxidant attributes. Extracts from these plants have shown promise in accelerating wound healing processes, enhancing fibroblast cell proliferation and migration, and providing antioxidant benefits. The objective of this work was to assess the therapeutic potential of extracts loaded patches for biomedical applications.

Methods

and extracts were prepared using the cold maceration method. The prepared extracts were evaluated for antibacterial activity and antioxidant potential. Additionally, patches were prepared using polyvinyl alcohol and hydroxypropyl methylcellulose as polymers and evaluated for release, cell viability and biocompatibility characteristics.

Results

The extract of both plants showed good antioxidant potency against ascorbic acid. Antibacterial activity revealed that and extracts as well as patches consistently outperformed and at varying concentrations. Physiochemical evaluation of patches indicated good weight uniformity, thickness, and folding endurance, with slight moisture uptake. Drug release profiles showed significant results for all formulations. The results of cell viability for patches showed an increased cell proliferation and were nontoxic.

Conclusion

The study suggests that both extract and patch show excellent antibacterial activity against Staphylococcus aureus. The characterization results showed that the patches were uniform in their drug content, weight, and thickness, and they also indicated the reproducibility of the method used. In the release study of and patches were fitted to the Higuchi model and also patches were found harmless for the cells as well as increased proliferation of cells.

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2025-01-30
2025-07-17

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References

  1. RahmanL. LembangR.S. LalloS. HandayaniS.R. Usmanengsi PermanaA.D. Bioadhesive dermal patch as promising approach for improved antibacterial activity of bioactive compound of Zingiber cassumunar Roxb in ex vivo Staphylococcus aureus skin infection model.J. Drug Deliv. Sci. Technol.20216310252210.1016/j.jddst.2021.102522
     [Google Scholar]
  2. Al-GhanayemA.A. AlhussainiM.S. AsadM. JosephB. Moringa oleifera leaf extract promotes healing of infected wounds in diabetic rats: Evidence of antimicrobial, antioxidant and proliferative properties.Pharmaceuticals (Basel)202215552810.3390/ph1505052835631354
     [Google Scholar]
  3. VongsakB. SithisarnP. MangmoolS. ThongpraditchoteS. WongkrajangY. GritsanapanW. Maximizing total phenolics, total flavonoids contents and antioxidant activity of Moringa oleifera leaf extract by the appropriate extraction method.Ind. Crops Prod.20134456657110.1016/j.indcrop.2012.09.021
     [Google Scholar]
  4. BhallaN. IngleN. PatriS.V. HaranathD. Phytochemical analysis of Moringa oleifera leaves extracts by GC-MS and free radical scavenging potency for industrial applications.Saudi J. Biol. Sci.202128126915692810.1016/j.sjbs.2021.07.07534866991
     [Google Scholar]
  5. Kumar T, Sah NK. Biochemical investigation of Sanjeevani, progressive research 2016; 11(3); 365-369.
  6. DakshayaniSS MarulasiddeshwaraMB KumarS GollaR DevarajaSR HosamaniR. Antimicrobial, anticoagulant and antiplatelet activities of green synthesized silver nanoparticles using Selaginella (Sanjeevini) plant extract.International Journal of Biological Macromolecules2019Jun 15; 131: 787-97.10.1016/j.ijbiomac.2019.01.222 30876901
     [Google Scholar]
  7. PaswanS.K. SrivastavaS. Venkateswara RaoC. Wound healing activity of ethanolic extract of Selaginella bryopteris on rats.Pharmacogn. J.202012233534110.5530/pj.2020.12.53
     [Google Scholar]
  8. DalimuntheA. Determination of total phenolic content, total flavonoid content, and antimutagenic activity of ethanol extract nanoparticles of Rhaphidophora pinnata (Lf) Schott leaves.Rasayan J. Chem.2018112
     [Google Scholar]
  9. StankovicM.S. Total phenolic content, flavonoid concentration and antioxidant activity of Marrubium peregrinum L. extracts.Kragujevac J. Sci.2011336372
     [Google Scholar]
  10. Govardhan SinghR.S. NegiP.S. RadhaC. Phenolic composition, antioxidant and antimicrobial activities of free and bound phenolic extracts of Moringa oleifera seed flour.J. Funct. Foods2013541883189110.1016/j.jff.2013.09.009
     [Google Scholar]
  11. DewanganG. KoleyK.M. VadlamudiV.P. MishraA. PoddarA. HirpurkarS.D. Antibacterial activity of Moringa oleifera (drumstick) root bark.J. Chem. Pharm. Res.201026424428
     [Google Scholar]
  12. MacêdoL.A.R.O. Oliveira JúniorR.G. SouzaG.R. de OliveiraA.P. de LavorÉ.M. SilvaM.G. PachecoA.G.M. de MenezesI.R.A. CoutinhoH.D.M. PessoaC.Ó. da CostaM.P. AlmeidaJ.R.G.S. Chemical composition, antioxidant and antibacterial activities and evaluation of cytotoxicity of the fractions obtained from Selaginella convoluta (Arn.) Spring (Selaginellaceae).Biotechnol. Biotechnol. Equip.201832250651210.1080/13102818.2018.1431055
     [Google Scholar]
  13. AmabyeT.G. TadesseF.M. Phytochemical and antibacterial activity of Moringa oleifera available in the market of Mekelle.J. Anal. Pharm. Res.20162114
     [Google Scholar]
  14. VishwakarmaA.K. MauryaO.P. NimishaD.S. Formulation and evaluation of transdermal patch containing turmeric oil.Int. J. Pharm. Pharm. Sci.201245358361
     [Google Scholar]
  15. PuttarakP. PichayakornW. SripokaK. ChaimudK. PanichayupakaranantP. Preparation of centella extracts loaded Aloe vera transdermal patches for wound healing purpose.Adv. Mat. Res.201510605457
     [Google Scholar]
  16. DavidS.R. Abd MalekN. MahadiA.H. ChakravarthiS. RajabalayaR. Development of controlled release silicone adhesive–based mupirocin patch demonstrates antibacterial activity on live rat skin against Staphylococcus aureus. Drug Des. Devel. Ther.20181248149410.2147/DDDT.S14654929563773
     [Google Scholar]
  17. RavichandiranV. ManivannanS. Wound healing potential of transdermal patches containing bioactive fraction from the bark of Ficus racemosa.Int. J. Pharm. Pharm. Sci.201576326
     [Google Scholar]
  18. RN. MK. JP. K SV. ArpanaC. BalashanmugamP. VenkatasubbuG.D. Enhanced wound healing by PVA/Chitosan/Curcumin patches: In vitro and in vivo study.Colloids Surf. B Biointerfaces201918211033910.1016/j.colsurfb.2019.06.06831284147
     [Google Scholar]
  19. SilvaA.C. SantosP.D.F. SilvaJ.T.P. LeimannF.V. BrachtL. GonçalvesO.H. Impact of curcumin nanoformulation on its antimicrobial activity.Trends Food Sci. Technol.201872748210.1016/j.tifs.2017.12.004
     [Google Scholar]
  20. GautamA. PalL.C. RaoC.V. KumarV. The role of Indian magical herb Selaginella bryopteris L. (Selaginaceae) in pharmacotherapeutic perspective: An overview.Pharmacogn. J.2023151142010.5530/pj.2023.15.3
     [Google Scholar]
  21. Vergara-JimenezM. AlmatrafiM. FernandezM. Bioactive components in Moringa oleifera leaves protect against chronic disease.Antioxidants2017649110.3390/antiox604009129144438
     [Google Scholar]
  22. b PaganoC. PerioliL. BaiocchiC. BartocciniA. BeccariT. BlasiF. CalarcoP. CeccariniM.R. CossignaniL. di MicheleA. OrtenziR. ScuotaS. RicciM. Preparation and characterization of polymeric microparticles loaded with Moringa oleifera leaf extract for exuding wound treatment.Int. J. Pharm.202058711970010.1016/j.ijpharm.2020.11970032738457
     [Google Scholar]
  23. ChinC.Y. JalilJ. NgP.Y. NgS.F. Development and formulation of Moringa oleifera standardised leaf extract film dressing for wound healing application.J. Ethnopharmacol.201821218819910.1016/j.jep.2017.10.01629080829
     [Google Scholar]
  24. AliA. GargP. GoyalR. KhanA. NegiP. LiX. KulshresthaS. An efficient wound healing hydrogel based on a hydroalcoholic extract of Moringa oleifera seeds.S. Afr. J. Bot.202214519219810.1016/j.sajb.2021.05.003
     [Google Scholar]
  25. PaswanS.K. VermaP. SrivastavaS. RaoC.V. Assessment of toxicity and wound healing activity of Selaginella bryopteris extract.Drug Chem. Toxicol.202346462563310.1080/01480545.2022.207537835635134
     [Google Scholar]
/content/journals/raddf/10.2174/0126673878330303241230102355
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Natural Extract-Loaded Herbal Patches: Assessment for Biomedical Application
Recent Advances in Drug Delivery and Formulation 19, 156 (2025); https://doi.org/10.2174/0126673878330303241230102355
/content/journals/raddf/10.2174/0126673878330303241230102355
/content/journals/raddf/10.2174/0126673878330303241230102355
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  • Article Type:     Research Article
Keyword(s): antibacterial activity; antioxidant activity; herbal patches; Moringa oleifera; Selaginella bryopteris; wound healing

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