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Recent Patents on Anti-Cancer Drug Discovery - Online First
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The Prognostic Role of Interferon Gamma-inducible Protein 30 in Clear Cell Renal Cell Carcinoma with Immune Infiltrates
Authors: Wu Xu, Taihong Wu, Yufeng Liu, Yang Luo, Dawei Liu, Lingfei Yan, Qing Li and Tao WangAvailable online: 06 February 2025More LessBackground Recent research has demonstrated the significance of Interferon Gamma-Inducible Protein 30 (IFI30), an interferon gamma-induced protein, in the immune response to cancerous growths. However, the relationship between IFI30 expression levels, patient prognosis, and tumor-infiltrating lymphocytes in clear cell renal cell carcinoma (ccRCC) remains inadequately defined. Methods To ascertain the potential link b Read More
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Unveiling miR-1468-5p: A New Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma
Authors: Yi Chen, Dongbing Li and Yueyu FangAvailable online: 03 February 2025More LessBackground miR-1468-5p, a type of microRNA, is acknowledged for its crucial involvement in a variety of cancerous processes. Nonetheless, the specific impact of this microRNA on lung adenocarcinoma (LUAD) has not yet been clearly defined. Objective Our aim was to investigate how miR-1468-5p influences LUAD. Methods The Cancer Genome Atlas (TCGA) offered specimens for our research. Employing statistical techniqu Read More
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The Present State and Potential Applications of Artificial Intelligence in Cancer Diagnosis and Treatment
Authors: Anuja Mishra, Srishti Sharma and Swaroop Kumar PandeyAvailable online: 03 February 2025More LessAn aberrant increase in cancer incidences has demanded extreme attention globally despite advancements in diagnostic and management strategies. The high mortality rate is concerning, and tumour heterogeneity at the genetic, phenotypic, and pathological levels exacerbates the problem. In this context, lack of early diagnostic techniques and therapeutic resistance to drugs, sole awareness among the public, coup Read More
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Ubiquitination-related Gene UBTD1 Mediates Poor Prognosis of Colorectal Cancer and Affects Colorectal Cancer Cell Proliferation and Ferroptosis
Authors: Yuzhao Jin, Luyu Liao, Qianping Chen, Bufu Tang, Jin Jiang, Ji Zhu, Minghua Bai and Lingjiao GuoAvailable online: 15 January 2025More LessBackground Colorectal cancer (CRC) is the third most common cancer worldwide, and its occurrence and progression are often regulated by genetic and hereditary factors. Ubiquitination and the associated ubiquitin-binding enzymes and ligases regulate the tumor microenvironment and antitumor immunity to mediate tumor pathogenesis and progression. In this study, we examined the molecular characteristics and imm Read More
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Effect of Oral Posaconazole on Venetoclax Plasma Concentration and its Efficacy in Patients with Acute Myeloid Leukemia
Authors: Mengqi Guo, Yingzhi He, Jingwen Du, Dezhi Qiu, Yinjie Qin and Yuxian HuangAvailable online: 08 January 2025More LessBackground BCL-2 was the first gene identified to have antiapoptotic effects, and venetoclax is an oral selective BCL-2 inhibitor, which has great potential in the treatment of patients with acute myeloid leukemia (AML) who are not candidates for intensive therapy. Notably, posaconazole, an oral antifungal drug, is also a strong factor that can affect blood venetoclax concentrations. To the best of our knowledge, the relationshi Read More
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A Single-arm, Open-label, Phase Ib Clinical Study Evaluating the Efficacy andSafetyofDurvalumabinCombinationwithAlbumin-bound Paclitaxel and Carboplatin as Neoadjuvant Therapy for Resectable Stage III Non-small Cell Lung Cancer
Authors: Yuejiao Zhong, Tao Li, Zhaoshi Bai, Ninglei Qiu, Siwen Liu, Wenjia Xia, Qiang Wei and Lingxiang ChenAvailable online: 06 January 2025More LessObjective This study aimed to explore the clinical efficacy and safety of durvalumab combined with albumin-bound paclitaxel and carboplatin as neoadjuvant therapy for resectable stage III Non-small Cell Lung Cancer (NSCLC). Methods A single-arm open-label phase Ib study was conducted. A total of 40 patients with driver gene-negative resectable stage III NSCLC were enrolled. All patients received neoadjuvant treatment wi Read More
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Differential Expression and Distribution of Slco4a1 and Slco1b2 in an Internal Environment Disorder-induced Hepatocellular Carcinoma Mouse Model
Authors: Haoxuan Luo, Yang Xie, Shan Huang and Yu ZhangAvailable online: 03 January 2025More LessObjective This study aims to enhance the understanding of underlying mechanisms and potential therapies of the solute carrier organic anion (SLCO) transporter family in internal environment disorder (IED)-induced hepatocellular carcinoma (HCC). This could lead to new therapeutic strategies and offer new directions for the creation of new patents for HCC treatment products. Methods The orthotopic transplantation Read More
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Covalent Inhibitor Screening for Targeting LOXL2: Studied by Virtual Screening and Experimental Validation
Authors: Lirui Lin, Kai Lin, Lichun Chen, Yiwen Wang, Li-Yan Xu, En-Min Li, Qingping Liu, Haiying Zou and Geng DongAvailable online: 02 January 2025More LessBackground Lysyl oxidase-like 2 (LOXL2) is a metalloenzyme that catalyzes oxidative deamination ε-amino group of lysine. It has been found that LOXL2 is a promotor for the metastasis and invasion in kinds of tumors. Previous studies show that disulfide bonds are important components in LOXL2, and their bioactivity can be regulated by those bonds. In this way, a small molecule covalently binds to the thiol group of cysteine Read More
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Dosimetry Comparison of 3D Conformal Radiotherapy and Intensity-modulated Radiotherapy for the Treatment of Brain Tumors: A Meta-Analysis
Authors: Ashima Barman, Sagor Kumar Roy, Sujan Mahamud, Nupur Karmaker and Md. Nurul IslamAvailable online: 29 October 2024More LessBackground This study aimed to evaluate IMRT and 3D-CRT in the therapy of brain tumor (BT) in relation to dose-volume histograms (DVHs) parameters, such as Heterogeneity Index (HI), Conformity index (CI), Equivalent Uniform Dose (EUD), and mean dose (Dmean) outcomes, including the program for the tumors of the brain and estimate whether a favored procedure can be found through the features of the pretreatm Read More
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West African Medicinal Plant Substances and Molecules Activities Against Viral Hepatitis B and Hepatocellular Carcinoma
Authors: Pengdwendé Fabienne Ingrid Zongo, Bagora Bayala and Jacques SimporeAvailable online: 21 October 2024More LessBackground Chronic hepatitis B virus (HBV) infection remains a major global public health problem with devastating consequences, such as hepatocellular carcinoma. Currently, approved treatments are limited to interferon and nucleoside/nucleotide analogues for chronic hepatitis B and chemotherapy, radiotherapy, and surgery for cancer. Both treatments have their limitations, making complete cure an elusive goal. The Read More
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Quercetin Promotes the M1-to-M2 Macrophage Phenotypic Switch During Liver Fibrosis Treatment by Modulating the JAK2/STAT3 Signaling Pathway
Authors: Dongqi Sun, Xiaoling Zhou, Teng Wu, Zepeng Li, Shigao Huang and Zheng PengAvailable online: 02 October 2024More LessObjective To investigate the underlying mechanism by which quercetin (Que) regulates macrophage polarization and its subsequent therapeutic effect on liver fibrosis, an important pathological precondition for hepatocellular carcinoma (HCC). Methods In vitro experiments were performed on the RAW264.7 mouse macrophage line. After the induction of M1-type macrophages with LPS, the effects of Que on cell morphology, Read More
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