Recent Patents on Anti-Cancer Drug Discovery - Volume 20, Issue 1, 2025

Digestive system neoplasms are highly heterogeneous and exhibit complex resistance mechanisms that render anti-programmed cell death protein (PD) therapies poorly effective. The tumor microenvironment (TME) plays a pivotal role in tumor development, apart from supplying energy for tumor proliferation and impeding the body's anti-tumor immune response, the TME actively facilitates tumor progression and immune e Read More

The development of cancer has been a multistep process involving mutation, proliferation, survival, invasion, and metastasis. Of all the characteristics of cancer, metastasis is believed to be the hallmark as it is responsible for the highest number of cancer-related deaths. In connection with this, Matrix metalloproteinases (MMPs), that has a role in metastasis, are one of the novel therapeutic targets. MMPs bel Read More

BackgroundRecent studies reported that terminal nucleotidyltransferase 5A (TENT5A) is highly expressed in glioblastoma and associated with poor prognosis. In this work, we aim to specify the expression level of TENT5A in different grades of glioma and explore its role in glioma progression.MethodsGEPIA online tools were used to perform the bioinformatic analysis. qRT-PCR, Western blot, and Immunohistochemi Read More

BackgroundArginine plays significant and contrasting roles in breast cancer growth and survival. However, the factors governing arginine balance remain poorly characterized.ObjectiveWe aimed to identify the molecule that governs arginine metabolism in breast cancer and to elucidate its significance.MethodsWe analyzed the correlation between the expression of solute carrier family 7 member 3 (SLC7A3), the major argin Read More

BackgroundAberrant expression of tumor protein D52 (TPD52) is associated with some tumors. The role of TPD52 in uterine corpus endometrial carcinoma (UCEC) remains uncertain.ObjectiveWe aimed to investigate the involvement of TPD52 in the pathogenesis of UCEC.MethodsWe employed bioinformatics analysis and experimental validation in our study.ResultsOur findings indicated that elevated TPD52 expression Read More

IntroductionOvarian Cancer (OC) is a heterogeneous malignancy with poor outcomes. Oxidative stress plays a crucial role in developing drug resistance. However, the relationships between Oxidative Stress-related Genes (OSRGs) and the prognosis of platinum-resistant OC remain unclear. This study aimed to develop an OSRGs-based prognostic risk model for platinum-resistant OC patients.MethodsGene Set Enrichment An Read More

BackgroundOsteosarcoma is a highly invasive bone marrow stromal tumor with limited treatment options. Oxidative stress plays a crucial role in the development and progression of tumors, but the underlying regulatory mechanisms are not fully understood. Recent studies have revealed the significant involvement of UBE2L3 in oxidative stress, but its specific role in osteosarcoma remains poorly investigated.ObjectiveThis stu Read More

BackgroundIt has already been shown that melatonin is an antitumoral molecule that affects malignant cells via some mechanisms. The benefit played by this hormone on cancer is due to its antioxidant effects.ObjectiveThis study aimed to evaluate the preclinical effects of melatonin in mice with the Ehrlich ascites tumor.MethodsTwenty Balb/c male mice with Ehrlich tumor were treated with different melatonin doses. Their inf Read More

IntroductionSplenic marginal zone Lymphoma (SMZL) is a rare, chronic B lymphocyte proliferative disease. Generally, SMZL is accompanied by circulating atypical villous lymphocytes, known as SMZL with villous lymphocytes. Rituximab is a chimeric monoclonal antibody to CD20; recent but limited studies have confirmed its effectiveness in treating SMZL. Given the low incidence and selection of treatment, statistical compari Read More

BackgroundIntracholecystic papillary neoplasms (ICPNs) represent a rare benign entity characterized by intraluminal polypoid lesions in the gallbladder. The incidence of ICPNs ranges from 0.4% to 0.61% in all gallbladder specimens.Case PresentationIn this report, we present a case of a young Caucasian woman who underwent elective laparoscopic cholecystectomy due to gallbladder polyps. The histological examination Read More