Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Recent Patents on Anti-Cancer Drug Discovery
  4. Volume 20, Issue 1
  5. Article
Volume 20, Issue 1
  • ISSN: 1574-8928
  • E-ISSN: 2212-3970

Abstract

Background

Intracholecystic papillary neoplasms (ICPNs) represent a rare benign entity characterized by intraluminal polypoid lesions in the gallbladder. The incidence of ICPNs ranges from 0.4% to 0.61% in all gallbladder specimens.

Case Presentation

In this report, we present a case of a young Caucasian woman who underwent elective laparoscopic cholecystectomy due to gallbladder polyps. The histological examination revealed the presence of an intracholecystic papillary neoplasm (ICPN) with a tubulopapillary growth pattern, exhibiting gastric morphology and displaying both low and high-grade dysplasia. A thorough review of the existing literature was conducted, with a specific focus on the histological features.

Conclusion

A comprehensive understanding of neoplastic polyps of the gallbladder is still limited. Pathological examination of these lesions is crucial for identifying key features that can influence patient outcomes and survival.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/pra/10.2174/0115748928256837231012151452
2023-10-25
2025-01-04

  • From This Site

    /content/journals/pra/10.2174/0115748928256837231012151452
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. WHO Classification of Tumours Editorial Board Digestive system tumours Lyon (France) International Agency for Research on Cancer. In: WHO classification of tumours series.5th edition.2019
     [Google Scholar]
  2. AdsayV. JangK.T. RoaJ.C. Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): Clinicopathologic and immunohistochemical analysis of 123 cases.Am. J. Surg. Pathol.20123691279130110.1097/PAS.0b013e318262787c 22895264
     [Google Scholar]
  3. ArgonA. BarbetF.Y. NartD. The relationship between intracholecystic papillary-tubular neoplasms and invasive carcinoma of the gallbladder.Int. J. Surg. Pathol.201624650451110.1177/1066896916644781 27122163
     [Google Scholar]
  4. WongL.H. FerrerG. MayoS.C. Intracholecystic papillary-tubular neoplasm of the gallbladder.J. Gastrointest. Surg.202226497998110.1007/s11605‑021‑05193‑w 34741253
     [Google Scholar]
  5. MyersR.P. ShafferE.A. BeckP.L. Gallbladder polyps: Epidemiology, natural history and management.Can. J. Gastroenterol.200216318719410.1155/2002/787598 11930198
     [Google Scholar]
  6. Albores-SaavedraJ. VardamanC.J. VuitchF. Non-neoplastic polypoid lesions and adenomas of the gallbladder.Pathol. Annu.199328Pt 1145177 8416136
     [Google Scholar]
  7. ElmasryM LindopD DunneDFJ MalikH PostonGJ FenwickSW The risk of malignancy in ultrasound detected gallbladder polyps: A systematic review.Int J Surg201633Pt A283510.1016/j.ijsu.2016.07.061 27465099
     [Google Scholar]
  8. WennmackerS.Z. van DijkA.H. RaessensJ.H.J. Polyp size of 1 cm is insufficient to discriminate neoplastic and non-neoplastic gallbladder polyps.Surg. Endosc.20193351564157110.1007/s00464‑018‑6444‑1 30203209
     [Google Scholar]
  9. RiddellZ.C. CoralloC. AlbazazR. FoleyK.G. Gallbladder polyps and adenomyomatosis.Br. J. Radiol.20239611422022011510.1259/bjr.20220115 35731858
     [Google Scholar]
  10. FoleyK.G. LahayeM.J. ThoeniR.F. Management and follow-up of gallbladder polyps: Updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.Eur. Radiol.20223253358336810.1007/s00330‑021‑08384‑w 34918177
     [Google Scholar]
  11. KiruthigaK.G. KodiatteT.A. BuradD. Intracholecystic papillary-tubular neoplasms of the gallbladder – A clinicopathological study of 36 cases.Ann. Diagn. Pathol.201940889310.1016/j.anndiagpath.2019.04.014 31077876
     [Google Scholar]
  12. LimaiemF. OmraniS. HajriM. BaccoucheS. Bifocal intracholecystic tubulopapillary neoplasm: A rare and distinct tumor of the gallbladder.Clin. Case Rep.2022103e0566310.1002/ccr3.5663 35356186
     [Google Scholar]
  13. Saei HamedaniF. Garcia-BuitragoM. Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder: A short review of literature.Appl. Immunohistochem. Mol. Morphol.2020281576110.1097/PAI.0000000000000711 31815746
     [Google Scholar]
  14. Albores-SaavedraJ. Chablé-MonteroF. González-RomoM.A. Ramírez JaramilloM. HensonD.E. Adenomas of the gallbladder. Morphologic features, expression of gastric and intestinal mucins, and incidence of high-grade dysplasia/carcinoma in situ and invasive carcinoma.Hum. Pathol.20124391506151310.1016/j.humpath.2011.11.011 22386521
     [Google Scholar]
  15. Albores-SaavedraJ. HensonD.E. Pyloric gland metaplasia with perineural invasion of the gallbladder.Cancer199986122625263110.1002/(SICI)1097‑0142(19991215)86:12<2625::AID‑CNCR6>3.0.CO;2‑D 10594857
     [Google Scholar]
  16. BennettS. Celia MargineanE. Paquin-GobeilM. Clinical and pathological features of intraductal papillary neoplasm of the biliary tract and gallbladder.HPB201517981181810.1111/hpb.12460 26278323
     [Google Scholar]
  17. McClellanJ.M. EscobarM.A.Jr Intracholecystic papillary-tubular neoplasm of the gallbladder presenting.J. Pediatr. Surg. Case Rep.201725464810.1016/j.epsc.2017.07.012
     [Google Scholar]
  18. YasirS. EricksonL.A. Intracholecystic papillary-tubular neoplasm of the gallbladder.Mayo Clin. Proc.201893121883188410.1016/j.mayocp.2018.10.013 30522601
     [Google Scholar]
  19. HazarikaP. SharmaM. Intracholecystic papillary–tubular neoplasm of gallbladder: A 5-year retrospective pathological study.Indian J. Pathol. Microbiol.201861451651910.4103/IJPM.IJPM_489_17 30303140
     [Google Scholar]
/content/journals/pra/10.2174/0115748928256837231012151452
Loading
Intracholecystic Papillary-tubular Neoplasm (ICPN) of the Gallbladder: A Case Report Focusing on an Unexpected Pathological Finding
Recent Patents on Anti-Cancer Drug Discovery 20, 131 (2025); https://doi.org/10.2174/0115748928256837231012151452
/content/journals/pra/10.2174/0115748928256837231012151452
/content/journals/pra/10.2174/0115748928256837231012151452
Loading

Data & Media loading...


  • Article Type:     Case Report
Keyword(s): Gallbladder polyps; laparoscopic cholecystectomy; papillary-tubular neoplasm; pathological study ICPN; premalignant gallbladder; specimens

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test