Protein and Peptide Letters - Volume 25, Issue 4, 2018

Introduction: Laser Therapy (LT) has been employed for the treatment of Oral Mucositis (OM) due to its anti-inflammatory, analgesic and bio-stimulatory effects. Objective: This pilot study investigated the effect of LT on the expression of DEFB1, DEFB4, DEFB103 genes encoding for the human β-defensins 1, 2 and 3. Materials and Method: TR146 epithelial cell line, used to mimic oral mucosa, was irradiated with different Read More

Background: Human serum albumin acts as a carrier protein to a variety of drugs and aids their transport. Andrographis paniculata, a herbal plant has been used as a source of traditional medicine in the Asian countries. Among the various constituents of this plant, andrographolide is the most active and is being used from centuries in the treatment of many chronic and infectious diseases. Objective: The present study was desi Read More

Introduction: Interaction of surfactants with proteins can decipher important information regarding the stability and behavior of proteins. For multi-domain proteins, these interactions vary domain wise and these details are crucial in understanding the contribution of different domains of the protein in its overall activity. Objective: The objective of the present work is to study the interaction of surfactants with domain III of Hum Read More

Background: SjOgren's Syndrome (SS) is a systemic and chronic autoimmune disorder that affects the exocrine glands with massive autoantibody production. Although the pathogenesis of the disorder is incompletely understood, but some studies have reported that anti-moesin antibodies have been detected in autoimmune diseases with which SS is closely associated. Here, we have investigated moesin's potential involvement i Read More

Background: Type 2 Diabetes (T2D) is a metabolic disease which affects glucose homeostasis caused due to inability of the target cells to respond to insulin. Role of vitamin D in the pathogenesis and prevention of T2D has sparked widespread interest. Vitamin D plays a classical role in Ca++ homeostasis as well as regulates insulin secretion from β-cells and its action on various target cells. Proteins are the vital components of Read More

Background: Protein-carbohydrate interactions play vital roles in several biological processes in living organisms. The comparative analysis of binding site residues along with stabilizing residues in protein-carbohydrate complexes provides ample insights to understand the structure, function and recognition mechanism. Objective: The main objective of this study is to identify and analyze the residues, which are involv Read More

Background: The 5HT2A G-Protein Coupled Receptor (GPCR) is an important family of receptors involved in an array of neuromodulatory functions. Their dysregulation has been implicated in a number of psychiatric diseases. In spite of the importance of this GPCR, high resolution structure and mechanistic details of its function is unknown. Cholesterol plays an important role in the function of many receptors and reduced cholest Read More

Background: The role of intracellular proteins in the pathogenesis of absence epilepsy were mentioned. These proteins are thought to be related to energy generation, signal transduction, inflammation processes and membrane conductance. Objectives: The investigation of protein profile of the genetically epileptic rat brains was the main subject of this study. Methods: For this, a 2D-gel electrophoresis based comparative proteo Read More