Skip to content
2000
Volume 25, Issue 4
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

Introduction: Laser Therapy (LT) has been employed for the treatment of Oral Mucositis (OM) due to its anti-inflammatory, analgesic and bio-stimulatory effects. Objective: This pilot study investigated the effect of LT on the expression of DEFB1, DEFB4, DEFB103 genes encoding for the human β-defensins 1, 2 and 3. Materials and Method: TR146 epithelial cell line, used to mimic oral mucosa, was irradiated with different LT protocols. β-defensins gene expression was evaluated using TaqMan probes on Real- Time PCR platform. Results and Conclusion: In this cellular model LT decreased mRNA defensins' expression 30 minutes after irradiation but not 24 hours later, suggesting that LT is able to influence β -defensins production immediately after treatment, while its efficacy decreases over time.

Loading

Article metrics loading...

/content/journals/ppl/10.2174/0929866525666180221123249
2018-04-01
2025-07-08
Loading full text...

Full text loading...

/content/journals/ppl/10.2174/0929866525666180221123249
Loading

  • Article Type:
    Research Article
Keyword(s): gene expression; Innate immunity; laser therapy; oral mucositis; real time PCR; β-defensins
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test