Protein and Peptide Letters - Volume 25, Issue 9, 2018

Background: Proteins through post translational modifications perform their biological process and cellular functions. Post-translational modifications play important roles in various biological process and cell functions. Identifying the PTMs sites in proteins is very significant to basic research and drug design. Experimental technique to identify post translational modifications is laborious. Computational identification o Read More

Background: Cysteine S-sulfenylation is a major type of dynamic post-translational modification of the protein that plays an important role in regulating many biological processes in both of prokaryotic and eukaryotic species. To understand the function of S-sulfenylated proteins, identification of S-sulfenylation sites is an essential step. Due to numerous restrictions of experimental methods, computational predictio Read More

Background: In the post-genome age, it is more urgent to understand the functions of genes and proteins. Since experimental methods are usually costly and time consuming, computational predictions are recognized as an alternative approach. In developing a predictive method for functional genomics and proteomics, one of the most important steps is to represent biological sequences with a fixed length numerical form, whic Read More

Background: During recent years, a lot of experimental studies have shown that lncRNA-binding proteins play a key role in many biomedical processes. Therefore, it is important to predict the potential lncRNA-protein associations in biomedical researches. Objective: To predict the associations between lncRNAs and proteins more reliably and more efficiently. Method: Considering the limitations of previous computati Read More

Background: Amyloids could be created under destabilizing conditions from various proteins. Having high chemical reactive groups makes the amyloid fibers suitable for enzyme stabilization. Imobilization of lipase as one of the stable classes of high catalytic power enzymes could be very valuable. Objective: In the present study, the lipase from Pseudomonas cepacia was immobilized on BSA amyloid nano-biofibrils and the Read More

Background: Marine sponges, belonging to the phylum Porifera, are gaining more attention by researchers and industrial sectors from all over the world due to their ability to produce a variety of bioactive secondary metabolites that have many applications including drug discovery. Marine sponges are a promising source of bioactive lectins, which are structurally diverse, many of them in the form of glycoproteins. Objective Read More

Background: Rheumatoid arthritis is the most common inflammatory autoimmune disease in the world. Recently new targets for its detection were developed as alternatives to classic biomarkers, including the M-12 peptide, that mimics carbonic anhydrase III. Thus, the application of this peptide for the development of new detection devices is attractive. Objective: Our goal was to construct a modified electrode for immobilization Read More