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Protein and Peptide Letters - Online First
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Unveiling the Potential Role of Hesperetin and Emodin as a Combination Therapy to Inhibit the Pancreatic Cancer Progression against the C-Met Gene
Available online: 24 March 2025More LessBackground Pancreatic adenocarcinoma (PAAD) is one of the most prevalent cancers, and it has high death rates. Only 10% of PAAD patients can survive until 5 years. Hence, the improvement of survival rate of the patients should be improved. Aim The present study used a computational approach to identify novel biomarkers and potentially effective small drug-like molecules in PAAD. Objective The objective of this study w Read More
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Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential
Authors: Reema Mishra, Preeti Agarwal, Anshita Sharma, Meenal Mittal, Pooja Gulati and Aparajita MohantyAvailable online: 18 March 2025More LessThe incidences of immune-related disorders have drastically increased in recent years across the world population. Treatment and management of these diseases, especially autoimmune disorders, are complex and challenging. Available synthetic drugs are not completely effective and also pose serious side effects for the patients. Cyclotides are a class of plant-derived cyclic peptides (28-37 amino acids) with three conserve Read More
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Diminazene Aceturate (DIZE) Ameliorates Hypertension and Induces Anxiolytic- and Antidepressant-Like Effects in TGR(Mren2)27
Available online: 24 February 2025More LessIntroduction Diminazene aceturate (DIZE) was described as an angiotensin-converting enzyme 2 (ACE2) activator. ACE2/Angiotensin-(1-7)/Mas receptor axis presents protective actions on cardiovascular diseases and plays an important modulatory role in the neurobiology of mood and anxiety disorders. Objectives To evaluate the effects of chronic intracerebroventricular (ICV) treatment with DIZE on blood pressure, anx Read More
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miR-584-5p Regulates MSMO1 to Modulate the AKT/PI3K Pathway and Inhibit Breast Cancer Progression
Available online: 11 February 2025More LessIntroduction Endogenous microRNAs (miRNAs) are critical regulators of tumor progression, making their role in breast cancer an important area of investigation. Method This study examined the regulation of MSMO1 by miR-584-5p in breast cancer cells. Using bioinformatics and Western blotting, we confirmed MSMO1 expression in breast cancer cells and evaluated its effects on cell migration, invasion, and the AKT signali Read More
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Inconsistent Protein Stability Despite Pre-HECT Domain Helix: Unveiling Variability in HECT Ligases
Authors: Çağdaş Dağ, Cansu Deniz Tozkoparan Ceylan and Cemre Sare CansızAvailable online: 11 February 2025More LessIntroduction Ubiquitin and ubiquitin-like systems play crucial roles across a wide range of organisms, from simple to complex. Among the three enzyme-mediated post-translational modification (PTM) steps, the ligation step is the most critical. HERC5, a member of the HECT ligase family, is one of the three enzymes involved in the ISGylation system. However, the precise start points and lengths of the HECT domains in HECT Read More
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Anti-Cancer Bioactive Peptide Induces Apoptosis in Gastric Cancer Cells through TP53 Signaling Cascade
Authors: Qimuge Suyila, Xian Li and Xiulan SuAvailable online: 10 February 2025More LessIntroduction Gastric cancer has emerged as one of the major diseases threatening human health. Our previous studies indicated that the anti-cancer bioactive peptide (ACBP) inhibits the initiation and progression of gastric cancer through apoptosis and cell cycle arrest, yet the mechanisms remain unclear. To elucidate the relationships between the effects of ACBP and the levels of cell differentiation, as well as the functional Read More
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Molecular Interactions of the Antimicrobial Peptide Tritrpticin with Mixed Nanoaggregates: A Fluorescence Spectroscopy Study
Available online: 28 January 2025More LessIntroduction Tritrpticin (TRP3) is a peptide belonging to the cathelicidin family and has a broad spectrum of antimicrobial activity. However, this class of biomolecules can be easily degraded in the body, making it necessary to use an efficient transport system. The ability to form stable nanostructures from the interaction of glycyrrhizin saponin with the pluronic polymer F127 was demonstrated, forming mixed biopolyme Read More
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ZNF165: A Pan-Cancer Biomarker with Prognostic and Therapeutic Potential
Authors: Guizhen Lyu and Dongbing LiAvailable online: 24 January 2025More LessBackground The role of ZNF165 in only a few tumors has been reported. ZNF165 plays an important role in liver cancer, gastric cancer, and breast cancer, especially in regulating the immune microenvironment, promoting tumor cell proliferation and migration, and serving as a potential target for immunotherapy. Objective This study aimed to enhance an understanding of how the ZNF165 gene functions and influences cancer Read More
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MARVELD1 Promotes the Invasiveness in Pancreatic Adenocarcinoma through the Activation of Epithelial-to-Mesenchymal Transition
Authors: Xianwei Luo and Zhenming GaoAvailable online: 21 January 2025More LessBackground MARVEL domain-containing 1 (MARVELD1) has been implicated in the progression of several cancers, but its role in pancreatic adenocarcinoma (PAAD) remains poorly understood. Methods RNA-seq data from the TCGA-PAAD and GTEx-Pancreas cohorts were analyzed to assess MARVELD1 expression. Stable MARVELD1 knockdown and overexpression were conducted in BxPC3 and PANC-1 cells. Cell viabilit Read More
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ZP3 Expression in Pancreatic Adenocarcinoma: Its Implications for the Prognosis and Therapy
Authors: Guizhen Lyu and Dongbing LiAvailable online: 08 January 2025More LessBackground The role of Zona pellucida glycoprotein 3 (ZP3) is unclear in pancreatic adenocarcinoma (PAAD). Objective This study aimed to explore the role of ZP3 in PAAD. Methods A comparative analysis of ZP3 gene expression was performed to discern differences between various types of cancer and PAAD, leveraging data sourced from The Cancer Genome Atlas (TCGA). This study aimed to assess the role of ZP3 as a pote Read More
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Amphibian-Derived Antimicrobial Peptides: Essential Components of Innate Immunity and Potential Leads for New Antibiotic Development
Available online: 08 January 2025More LessLike other vertebrates, amphibians possess innate and adaptive immune systems. At the center of the adaptive immune system is the Major Histocompatibility Complex. The important molecules of innate immunity are antimicrobial peptides (AMPs). These peptides are secreted by granular glands in the skin and protect the animal against microorganisms entering its body through the skin. AMPs offer an effective an Read More
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Pro-fertility and Antioxidant Potentials of Vigna unguiculata (Cowpea) Protein Isolate and Essential Oil: An In vivo and In silico Studies
Available online: 03 January 2025More LessIntroduction Vigna unguiculata (Cowpea), a legume rich in phytochemicals, has been traditionally used to improve fertility and treat various ailments. This study used in-silico and in-vivo methods to evaluate the effects of cowpea protein isolate and essential oil on reproductive hormonal and antioxidant indices. Method Forty (40) female rats were divided into eight groups (n=5). After 14 days of treatment, hormone levels Read More
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