Pharmaceutical Nanotechnology - Online First

Aim This study aimed to develop and evaluate lornoxicam (LXM) and thiocolchicoside (TCS) transferosomal transdermal patches. Background Oral administration of LXM and TCS can lead to gastric irritation, necessitating alternative delivery methods for pain and inflammation relief. Incorporating LXM & TCS into transferosomes within a transdermal patch offers a potential solution. Objective The objective of this study Read More

Even with recent advancements in surgery and multimodal adjuvant therapy, brain cancer treatment is still difficult. The blood-brain barrier and the potentially deadly medications' non-specificity have made pharmacological treatment for brain cancer particularly ineffective. The nanoparticle has surfaced as a viable brain delivery vector that can solve the issues with existing approaches. Furthermore, it is possible to integrate man Read More

Introduction/ Background This study aimed to introduce a gel (NEG) formulation containing betulin-loaded nanoemulsions for topical psoriasis treatment. Materials and Methods The prepared nanoemulsions were optimized for smaller particle size and higher drug content using a response surface methodology that exhibited uniform distribution and high drug loading (21.17±3.55%). Results The gel demonstrated skin-comp Read More

Cancer continues to pose a formidable challenge in global health due to its incidence and increasing resistance to conventional therapies. A key factor driving this resistance is tumor hypoxia, characterized by reduced oxygen levels within cancer cells. This hypoxic environment triggers a variety of adaptive mechanisms, significantly compromising the efficacy of cancer treatments. Notably, hypoxia promotes metastasis an Read More

Alzheimer's disease (AD) is an irreversible brain disorder that led to memory loss and disrupts daily life. Earlier strategies to treat AD such as acetylcholinesterase inhibitor (AChEI) drugs are not showing effectiveness due to the inability to cross the blood-brain barrier. Moreover, traditional AChEI provides limited efficacy in terms of bioavailability and solubility for treating AD treatment. Many of the current drugs such as don Read More

Introduction Metal nanoparticles have received much attention due to their unique physical dynamics, chemical reactivity, and promising biological applications. Green synthesis using natural compounds is an alternative to traditional chemical methods for the synthesis of nanoparticles. Materials and Methods Herein, two secondary metabolites were isolated from different fractions of methanolic extract of Citrullus colocy Read More

Nanotechnology is rapidly transforming various fields, including medicine, environmental conservation, agriculture, and pharmaceuticals. The production of metallic nanoparticles is a key area within this field, known for its innovative applications. However, traditional chemical and physical methods used for nanoparticle synthesis often involve toxic chemicals and are expensive, making them unsuitable for large-scale produ Read More

Lipid-based nanocarriers have emerged as promising vehicles for the delivery of various therapeutic agents, owing to their biocompatibility, stability, and ability to encapsulate both hydrophilic and hydrophobic drugs. Among these lipid-based nanocarriers, Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) have gained significant attention in the field of drug delivery. This comparative review aims to Read More

Background Bacterial nanocellulose (BNC) is typically produced through fermentation using Hestrin Schramm (HS) médium. However, its high cost limits its use in industry. Moreover, curcumin, as a model substance, is a potential bioactive compound but has low bioavailability. This also limits its use for clinical application. Thus, a delivery system using more affordable production of BNC was develop to improve the lack property o Read More

Quercetin, a natural flavonoid, is well-proven for anticancer properties in a variety of cancers. Quercetin's anticancer action is driven by its anti-inflammatory and antioxidant properties. It inhibits pro-inflammatory cytokines (e.g., TNF-α, IL-6) and suppresses NF-κB and COX-2, reducing tumor growth. Its antioxidant activity neutralizes reactive oxygen species (ROS), preventing oxidative damage that can lead to cancer. Howeve Read More