Natural Products Journal, The - Volume 15, Issue 3, 2025

BackgroundFungi found in unique and competitive environments are abundant in bioactive compounds.ObjectiveThe objective of this study is to isolate and identify secondary metabolites from fungi of unique ecological niches and evaluate their cytotoxicity.MethodsThe compounds were isolated and purified using silica gel column chromatography, Sephadex LH-20 gel chromatography, and semi-preparative high-perform Read More

Diabetes Mellitus and its associated brain disorders become more prevalent across the globe. Several comorbidity factors are associated with diabetic mellitus as well as the nervous system. Static molecular variations in the Central Nervous System (CNS) due to Hyperglycemia may be a major cause of psychiatric disorders. Carbohydrates and proteins imbalance as metabolic parameters impact the downregulation of neu Read More

Natural products have evolved to interact with specific protein targets within cells, making them valuable for various biological functions. Chemical proteomics, specifically the use of covalently linked probes in live cells, allows for the identification of protein-binding partners or targets of small molecules. Recent advancements in target identification of natural products have utilized affinity-based probes and photo-affinity labelin Read More

n-Butylidene phthalide (N-BP) is a natural derivative obtained from the chloroform extract of Angelica Sinensis. In conventional medicine, it treats different ailments. Various pharmacological properties are associated with it, including anticancer, anti-inflammatory, and neuroprotective properties. Based on its reported pharmacokinetic profile, n-BP has low oral bioavailability and is rapidly absorbed and eliminated from t Read More

Background and ObjectivePrior research indicates that disruptions in melatonin secretion levels and timing could be linked to the pathophysiology of bipolar disorder. Our study aimed to assess the effectiveness of melatonin as an adjunctive therapy to classical mood stabilizers in addressing sleep impairment and mood symptoms in bipolar patients currently experiencing manic episodes.MethodsFifty-eight hospitalized patient Read More

BackgroundThe characterization of resistance-associated amino acid substitution (RAAS) in direct-acting antivirals (DAA) molecular targets could reshape the treatment strategy for HCV infection. Hence, this review aimed to provide evidence on the impact of the RAASs on DAA treatment for HCV.MethodsPRISMA model was followed for the literature survey and evaluation (sources: PubMed, Sci-Hub, and Google Scholar). RAAS Read More

Plant tissue culture is a process of in vitro regeneration requiring numerous resources and intensive labour to mass produce disease-free clones. Diverse factors such as sterilizing agents, media composition, and environmental conditions contribute toward successful regeneration and decide the production, such as the total shoot number, shoot length, in vitro rooting, and adaptation of plants to the external environment. Plan Read More