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Volume 15, Issue 2
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Background

is a versatile mushroom with potential therapeutic benefits. A variety of bioactive compounds have been found in this mushroom that have anti-ulcer, anti-inflammatory, immunomodulatory, and blood sugar and lipid regulating effects.

Objectives

The aim is to isolate and characterize compounds from the rice medium of and evaluate their potential therapeutic effects on oxidative stress-associated diseases.

Methods

Fifteen compounds were isolated and characterized using NMR spectra and ESI-MS. The effects of compounds and on LPS-induced nitric oxide (NO) generation in BV2 cells and HO-induced cytotoxicity in SH-SY5Y cells were investigated. The regulation of nitric oxide production and apoptosis-associated proteins Bcl-2 and Bax were also examined.

Results

Compounds and exhibited potent inhibitory effects on LPS-induced NO generation in microglial cells and significant resistance to HO-induced cytotoxicity in neuronal cells. Molecular docking simulations demonstrated the interaction of compounds and with iNOS and Bax, respectively. Western blot analysis revealed that inhibited NO production and regulated the expression of Bax and Bcl-2, suggesting a protective effect against HO-induced apoptosis.

Conclusion

Compounds and isolated from are potential therapeutic candidates for oxidative stress-associated diseases, possibly through their regulation of nitric oxide production and apoptosis-related proteins. Further investigations are warranted to elucidate their mechanisms of action and therapeutic potential.

© 2025 Bentham Science Publishers
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2025-02-01
2025-03-07

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/content/journals/npj/10.2174/0122103155295894240528061315
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Metabolites of Culinary-medicinal Mushroom Hericium erinaceus Showed Anti-neuroinflammatory Activity in BV2 Cells and Anti-H2O2-induced Oxidative Stress Activity in SH-SY5Y Cells
Natural Products Journal, The 15, E030624230635 (2025); https://doi.org/10.2174/0122103155295894240528061315
/content/journals/npj/10.2174/0122103155295894240528061315
/content/journals/npj/10.2174/0122103155295894240528061315
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  • Article Type:     Research Article
Keyword(s): Aliphatic acids; anti-neuroinflammatory; apoptosis; H. erinaceus; neuronal cells; nitric oxide; oxidative stress

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