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Current Reviews in Clinical and Experimental Pharmacology - Online First
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Genetic Determinants of Statin-induced Myopathy: A Network Meta-analysis of Observational Studies
Authors: Kannan Sridharan and Gowri SivaramakrishnanAvailable online: 28 March 2025More LessIntroduction Statin-induced myopathy (SIM) is a prevalent adverse event impacting treatment adherence. Despite extensive exploration of single nucleotide polymorphisms (SNPs), conflicting evidence obscures their role in SIM incidence, prompting this network meta-analysis. Methods Observational studies meeting eligibility criteria (patients on any statin with reported SNPs and SIM details) were systematically reviewed Read More
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Neurobiological Mechanisms of Ketamine Use, its Addiction, and Withdrawal: A Mini Review
Available online: 03 March 2025More LessKetamine, a substance used for anesthesia and known for inducing dissociation, can lead to addiction and the development of severe withdrawal symptoms. Ketamine alters brain networks before affecting somesthetic sensation. Ketamine abuse was especially prevalent in East and Southeast Asia, and its popularity has continued to expand globally in recent decades. Ketamine is gaining popularity in the public and private sect Read More
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Breaking the Mold: Advances and Hurdles in Antifungal Resistance Management for Dermatophytes
Available online: 30 January 2025More LessExamining antifungal resistance in dermatophytes is crucial in infectious diseases, dermatology, and clinical microbiology. The increasing occurrence of resistant infections and their influence on the effectiveness of therapy seem overwhelming. This study examines the present condition of antifungal resistance in dermatophytes, highlighting the need for ongoing and up-to-date research. Fungal diseases constan Read More
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Probiotic: A Gut Microbiota-Based Therapeutic Approaches for the Treatment of Parkinson’s Disease
Authors: Monalisa Rout, Shakti Ketan Prusty and Durga Madhab karAvailable online: 23 December 2024More LessThe estimated worldwide number of individuals diagnosed with Parkinson's disease (PD) might exceed 10 million by 2040. However, the underlying evidence for PD is unclear. Recent research in Parkinson's disease has focused on exploring the gut-brain axis. Researchers have proposed that gut microbiota and gut dysbiosis contribute to peripheral inflammatory conditions. The involvement of gut pathogens and dysbiosis in periph Read More
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Pharmacogenetic Variations in Arab Populations: Clinical Implications for Personalized Drug Therapy
Available online: 23 December 2024More LessPrevious genetic studies on the genetic makeup of Arab populations highlight the diversity resulting from the distribution of specific genetic markers among various Arab descendant populations. Different genetic variants classified as clinically significant have been identified, impacting the response to administered drugs. Absorption, distribution, and excretion of drugs throughout the human body are managed through the Read More
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Influence of the Gut Microbiota, Metabolism and Environment on Neuropsychiatric Disorders
Authors: Mengxia Wang, Yan Ma, Bao Zeng, Wenhao Yang, Cuihong Huang and Benqin TangAvailable online: 13 December 2024More LessThe two-way communication between intestinal microbiota and the central nervous system (the microbiota-gut-brain axis) is involved in the regulation of brain function, neurodevelopment, and aging. The microbiota-gut-brain axis dysfunction may be a predisposition factor for Parkinson’s disease (PD), Alzheimer’s disease (AD), Autism spectrum disorder (ASD), and other neurological diseases. However, it is not clear wheth Read More
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The Role of Metformin in Modifying Ferroptosis to Treat Metabolic Dysfunction-Associated Fatty Liver Disease: A Narrative Review
Available online: 11 December 2024More LessFatty liver disease (FLD) is a well-known metabolic disorder associated with hepatic steatosis and tissue lipid accumulation. Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent and challenging condition that is linked to obesity, diabetes, and other metabolic disorders. MAFLD, previously called NAFLD or nonalcoholic fatty liver disease, is associated with pathological changes in liver tissue. In recent deca Read More
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Clinical Application of Pharmacogenomics in the Administratio of Common Cardiovascular Medications
Authors: Faaiq N. Aslam, Artur Schneider, Nikita Jhawar and Razvan ChirilaAvailable online: 02 December 2024More LessIntroduction Genomic variations among individuals can greatly affect their responses to different medications. Pharmacogenomics is the area of study that aims to understand the relationship between these various genetic variations and subsequent drug responses. Many medications used to optimize cardiovascular health are affected by these genetic variants and these relationships can subsequently impact dosing strategies Read More
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Bigels as Novel Drug Delivery Systems: A Systematic Review on Efficiency and Influential Factors
Available online: 30 October 2024More LessBackground Bigles are novel formulation merging two phase of hydrogel and organogel revealing dual properties to release active agents based on their lipophilic or hydrophilic nature. Methods A systematic search was conducted in PubMed, Scopus, and ISI Web of Science to find eligible studies evaluating the efficiency of bigels in drug release. 20 articles were included in the analysis based on the defined criteria. Results The res Read More
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Effectiveness and Tolerability of Various 5-Fluorouracil Formulations as Adjuvant Therapies for Vitiligo Management: A Systematic Review and Meta-Analysis
Authors: Neveen A. Kohaf, Sameh M. Sarsik, Samar Salman and Omnya M. AminAvailable online: 18 October 2024More LessBackground All vitiligo treatments are restricted, and no known treatment reliably produces repigmentation. In this study, we investigated the efficacy and safety of 5-Fluorouracil (5FU) as adjuvant therapy in treating vitiligo. Method Using five significant databases, an electronic systematic search of the literature was conducted. Randomized Clinical Trials (RCTs) that investigated 5FU for treating vitiligo in humans were select Read More
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Exploring the Role of Deutetrabenazine in the Treatment of Chorea Linked with Huntington's Disease
Authors: Siddhant Tripathi, Yashika Sharma and Dileep KumarAvailable online: 15 October 2024More LessBackground This review investigates the efficacy of deutetrabenazine in the management of chorea related to HD. Motor, psychological, and cognitive symptoms characterize HD, a neurodegenerative disease. One prominent movement disorder associated with HD is chorea, which results in uncontrollably jerky movements of the muscles. HD has no known cure; instead, symptom management with a variety of medication Read More
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Understanding Diabetic Wounds: A Review of Mechanisms, Pathophysiology, and Multimodal Management Strategies
Authors: Manisha, Niharika, Praveen Gaur, Radha Goel, Kanak Lata and Rosaline MishraAvailable online: 14 October 2024More LessIntroduction Diabetic wounds are a prevalent and impairing consequence of diabetes mellitus that significantly impacts people's lives and global healthcare systems. Because of disturbances in the wound-healing cascade, these intricate, persistent wounds frequently refuse to heal. Focusing on diabetic wound formation, this study seeks to clarify the complex mechanisms and pathophysiology involved while offering a thoroug Read More
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