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image of Breaking the Mold: Advances and Hurdles in Antifungal Resistance Management for Dermatophytes

Abstract

Examining antifungal resistance in dermatophytes is crucial in infectious diseases, dermatology, and clinical microbiology. The increasing occurrence of resistant infections and their influence on the effectiveness of therapy seem overwhelming. This study examines the present condition of antifungal resistance in dermatophytes, highlighting the need for ongoing and up-to-date research. Fungal diseases constantly change, and fungi have developed new resistance mechanisms. Here, we analyze the historical context of research on antifungal resistance, examining the variables that contribute to the development of resistance, such as the growing use of antifungals in clinical and agricultural contexts. We also explore the consequences of resistance to antifungal agents in clinical practice and public health. The review emphasizes the significance of new diagnostic technologies, like next-generation sequencing, in comprehending resistance mechanisms. It also underscores the crucial role of international collaboration in tackling this worldwide health concern. In conclusion, the paper emphasizes the need for continuous research to adjust to the evolving epidemiology of dermatophyte infections, create efficient treatment approaches, and guide public health interventions. This will ensure that the management of antifungal resistance is grounded in the most up-to-date scientific knowledge and optimal methods.

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2025-01-30
2025-05-04

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References

  1. Weitzman I. Summerbell R.C. The dermatophytes. Clin. Microbiol. Rev. 1995 8 2 240 259 10.1128/CMR.8.2.240 7621400
    [Google Scholar]
  2. Durdu M. Ilkit M. Strategies to improve the diagnosis and clinical treatment of dermatophyte infections. Expert Rev. Anti Infect. Ther. 2022 21 36329574
    [Google Scholar]
  3. Chepkwony J.K. Mwitari P.G. Kipsumbai P.K. Bii C.C. Tuei V.C. Anti-dermatophytic activity of Salvia nilotica methanolic crude leaf extract against Trichophyton mentagrophytes. Journal of Phytopharmacology 2021 10 6 433 438 10.31254/phyto.2021.10602
    [Google Scholar]
  4. Deng R. Wang X. Li R. Dermatophyte infection: From fungal pathogenicity to host immune responses. Front. Immunol. 2023 14 1285887 10.3389/fimmu.2023.1285887 38022599
    [Google Scholar]
  5. Moskaluk A.E. VandeWoude S. Current topics in dermatophyte classification and clinical diagnosis. Pathogens 2022 11 9 957 10.3390/pathogens11090957 36145389
    [Google Scholar]
  6. Sun C. Ren Y. Zhang W. Association between skin disease and anxiety: A logistic analysis and prediction. Ann. Transl. Med. 2023 11 2 115 10.21037/atm‑22‑6511 36819527
    [Google Scholar]
  7. Jartarkar S.R. Patil A. Goldust Y. Cockerell C.J. Schwartz R.A. Grabbe S. Goldust M. Pathogenesis, immunology and management of dermatophytosis. J. Fungi 2021 8 1 39 10.3390/jof8010039 35049979
    [Google Scholar]
  8. Kruithoff C. Gamal A. McCormick T.S. Ghannoum M.A. Dermatophyte infections worldwide: Increase in incidence and associated antifungal resistance. Life 2023 14 1 1 10.3390/life14010001 38276250
    [Google Scholar]
  9. Sacheli R. Hayette M.P. Antifungal resistance in dermatophytes: Genetic considerations, clinical presentations and alternative therapies. J. Fungi 2021 7 11 983 10.3390/jof7110983 34829270
    [Google Scholar]
  10. Pai V. Ganavalli A. Kikkeri N. Antifungal resistance in dermatology. Indian J. Dermatol. 2018 63 5 361 368 10.4103/ijd.IJD_131_17 30210155
    [Google Scholar]
  11. Martinez-Rossi N.M. Bitencourt T.A. Peres N.T.A. Lang E.A.S. Gomes E.V. Quaresemin N.R. Martins M.P. Lopes L. Rossi A. Dermatophyte resistance to antifungal drugs: Mechanisms and prospectus. Front. Microbiol. 2018 9 1108 10.3389/fmicb.2018.01108 29896175
    [Google Scholar]
  12. Fang W. Wu J. Cheng M. Zhu X. Du M. Chen C. Liao W. Zhi K. Pan W. Diagnosis of invasive fungal infections: Challenges and recent developments. J. Biomed. Sci. 2023 30 1 42 10.1186/s12929‑023‑00926‑2 37337179
    [Google Scholar]
  13. Verma S.B. Panda S. Nenoff P. Singal A. Rudramurthy S.M. Uhrlass S. Das A. Bisherwal K. Shaw D. Vasani R. The unprecedented epidemic-like scenario of dermatophytosis in India: III. Antifungal resistance and treatment options. Indian J. Dermatol. Venereol. Leprol. 2021 87 4 468 482 10.25259/IJDVL_303_20 34219433
    [Google Scholar]
  14. Mota Fernandes C. Dasilva D. Haranahalli K. McCarthy J.B. Mallamo J. Ojima I. Del Poeta M. The future of antifungal drug therapy: Novel compounds and targets. Antimicrob. Agents Chemother. 2021 65 2 e01719-20 10.1128/AAC.01719‑20 33229427
    [Google Scholar]
  15. Salam M.A. Al-Amin M.Y. Salam M.T. Pawar J.S. Akhter N. Rabaan A.A. Alqumber M.A.A. Antimicrobial resistance: A growing serious threat for global public health. Healthcare 2023 11 13 1946 10.3390/healthcare11131946 37444780
    [Google Scholar]
  16. Guerrant R.L. Walker D.H. Weller P.F. Tropical Infectious Diseases: Principles, Pathogens and Practice E-Book: Principles, Pathogens and Practice (Expert Consult - Online and Print). Elsevier Health Sciences 2011
    [Google Scholar]
  17. Keshwania P. Kaur N. Chauhan J. Sharma G. Afzal O. Alfawaz Altamimi A.S. Almalki W.H. Superficial dermatophytosis across the world’s populations: Potential benefits from nanocarrier-based therapies and rising challenges. ACS Omega 2023 8 35 31575 31599 10.1021/acsomega.3c01988 37692246
    [Google Scholar]
  18. Pires C.A.A. Cruz N.F.S. Lobato A.M. Sousa P.O. Carneiro F.R.O. Mendes A.M.D. Clinical, epidemiological, and therapeutic profile of dermatophytosis. An. Bras. Dermatol. 2014 89 2 259 264 10.1590/abd1806‑4841.20142569 24770502
    [Google Scholar]
  19. Sardana K. Gupta A. Mathachan S.R. Immunopathogenesis of dermatophytoses and factors leading to recalcitrant infections. Indian Dermatol. Online J. 2021 12 3 389 399 10.4103/idoj.IDOJ_503_20 34211904
    [Google Scholar]
  20. Garg J. Tilak R. Garg A. Prakash P. Gulati A. Nath G. Rapid detection of dermatophytes from skin and hair. BMC Res. Notes 2009 2 1 60 10.1186/1756‑0500‑2‑60 19374765
    [Google Scholar]
  21. Brescini L. Fioriti S. Morroni G. Barchiesi F. Antifungal combinations in dermatophytes. J. Fungi 2021 7 9 727 10.3390/jof7090727 34575765
    [Google Scholar]
  22. Martinez-Rossi N.M. Peres N.T.A. Bitencourt T.A. Martins M.P. Rossi A. State-of-the-art dermatophyte infections: Epidemiology aspects, pathophysiology, and resistance mechanisms. J. Fungi 2021 7 8 629 10.3390/jof7080629 34436168
    [Google Scholar]
  23. Ying Y.H. Lee W.L. Chi Y.C. Chen M.J. Chang K. Demographics, socioeconomic context, and the spread of infectious disease: The Case of COVID-19. Int. J. Environ. Res. Public Health 2022 19 4 2206 10.3390/ijerph19042206 35206390
    [Google Scholar]
  24. Havlickova B. Czaika V.A. Friedrich M. Epidemiological trends in skin mycoses worldwide. Mycoses 2008 51 s4 Suppl. 4 2 15 10.1111/j.1439‑0507.2008.01606.x 18783559
    [Google Scholar]
  25. Chanyachailert P. Leeyaphan C. Bunyaratavej S. Cutaneous fungal infections caused by dermatophytes and non-dermatophytes: An updated comprehensive review of epidemiology, clinical presentations, and diagnostic testing. J. Fungi 2023 9 6 669 10.3390/jof9060669 37367605
    [Google Scholar]
  26. Urban K. Chu S. Scheufele C. Giesey R.L. Mehrmal S. Uppal P. Delost G.R. The global, regional, and national burden of fungal skin diseases in 195 countries and territories: A cross-sectional analysis from the global burden of disease study 2017. JAAD International 2021 2 22 27 10.1016/j.jdin.2020.10.003 34409349
    [Google Scholar]
  27. Dogra S. Uprety S. The menace of chronic and recurrent dermatophytosis in India: Is the problem deeper than we perceive? Indian Dermatol. Online J. 2016 7 2 73 76 10.4103/2229‑5178.178100 27057485
    [Google Scholar]
  28. Verma S.B. Panda S. Nenoff P. Singal A. Rudramuruthy S.M. Uhrlass S. Das A. Bisherwal K. Shaw D. Vasani R. The unprecedented epidemic-like scenario of dermatophytosis in India: I. Epidemiology, risk factors and clinical features. Indian J. Dermatol. Venereol. Leprol. 2021 87 2 154 175 10.25259/IJDVL_301_20 33769736
    [Google Scholar]
  29. Coulibaly O. L’Ollivier C. Piarroux R. Ranque S. Epidemiology of human dermatophytoses in Africa. Med. Mycol. 2018 56 2 145 161 10.1093/mmy/myx048 28992062
    [Google Scholar]
  30. Teklebirhan G. Bitew A. Prevalence of dermatophytic infection and the spectrum of dermatophytes in patients attending a tertiary hospital in Addis Ababa, Ethiopia. Int. J. Microbiol. 2015 2015 653419 10.1155/2015/653419 26448763
    [Google Scholar]
  31. Lee W.J. Kim S.L. Jang Y.H. Lee S.J. Kim D.W. Bang Y.J. Jun J.B. Increasing prevalence of trichophyton rubrum identified through an analysis of 115,846 cases over the last 37 years. J. Korean Med. Sci. 2015 30 5 639 643 10.3346/jkms.2015.30.5.639 25931797
    [Google Scholar]
  32. Durgadevi G. Pk K. Shanthi G. Clinical profile of tinea capitis among rural children in Cuddalore district. Int J Dermatol Venereol Leprol Sci 2023 6 2 Part A 08 11
    [Google Scholar]
  33. Segal E. Elad D. Human and zoonotic dermatophytoses: Epidemiological aspects. Front. Microbiol. 2021 12 713532 10.3389/fmicb.2021.713532 34421872
    [Google Scholar]
  34. Rodríguez-Cerdeira C. Martínez-Herrera E. Szepietowski J.C. Pinto-Almazán R. Frías-De-León M.G. Espinosa-Hernández V.M. Chávez-Gutiérrez E. García-Salazar E. Vega-Sánchez D.C. Arenas R. Hay R. Saunte D.M. A systematic review of worldwide data on tinea capitis: Analysis of the last 20 years. J. Eur. Acad. Dermatol. Venereol. 2021 35 4 844 883 10.1111/jdv.16951 32976663
    [Google Scholar]
  35. Petrucelli M.F. Abreu M.H. Cantelli B.A.M. Segura G.G. Nishimura F.G. Bitencourt T.A. Marins M. Fachin A.L. Epidemiology and diagnostic perspectives of dermatophytoses. J. Fungi 2020 6 4 310 10.3390/jof6040310 33238603
    [Google Scholar]
  36. AlMaghrabi R.S. Al-Musawi T. Albaksami O. Subhi A.L. Fakih R.E. Stone N.R. AlMaghrabi R. Subhi A. Elfakih R. Stone N. Challenges in the management of invasive fungal infections in the Middle East: expert opinion to optimize management using a multidisciplinary approach. Cureus 2023 15 8 e44356 10.7759/cureus.44356 37779746
    [Google Scholar]
  37. Vanreppelen G. Wuyts J. Van Dijck P. Vandecruys P. Sources of antifungal drugs. J. Fungi 2023 9 2 171 10.3390/jof9020171 36836286
    [Google Scholar]
  38. Siopi M. Efstathiou I. Theodoropoulos K. Pournaras S. Meletiadis J. Molecular epidemiology and antifungal susceptibility of trichophyton isolates in Greece: Emergence of terbinafine-resistant Trichophytonmentagrophytes type VIII locally and globally. J. Fungi 2021 7 6 419 10.3390/jof7060419 34072049
    [Google Scholar]
  39. Jiang Y. Luo W. Verweij P.E. Song Y. Zhang B. Shang Z. Al-Hatmi A.M.S. Ahmed S.A. Wan Z. Li R. de Hoog G.S. Regional differences in antifungal susceptibility of the prevalent dermatophyte trichophyton rubrum. Mycopathologia 2021 186 1 53 70 10.1007/s11046‑020‑00515‑z 33313977
    [Google Scholar]
  40. Singh A. Masih A. Monroy-Nieto J. Singh P.K. Bowers J. Travis J. Khurana A. Engelthaler D.M. Meis J.F. Chowdhary A. A unique multidrug-resistant clonal Trichophyton population distinct from Trichophyton mentagrophytes/Trichophyton interdigitale complex causing an ongoing alarming dermatophytosis outbreak in India: Genomic insights and resistance profile. Fungal Genet. Biol. 2019 133 103266 10.1016/j.fgb.2019.103266 31491507
    [Google Scholar]
  41. Nenoff P. Verma S.B. Ebert A. Süß A. Fischer E. Auerswald E. Dessoi S. Hofmann W. Schmidt S. Neubert K. Renner R. Sohl S. Hradetzky U. Krusche U. Wenzel H.C. Staginnus A. Schaller J. Müller V. Tauer C. Gebhardt M. Schubert K. Almustafa Z. Stadler R. Fuchs A. Sitaru C. Retzlaff C. Overbeck C. Neumann T. Kerschnitzki A. Krause S. Schaller M. Walker B. Walther T. Köhler L. Albrecht M. Willing U. Monod M. Salamin K. Burmester A. Koch D. Krüger C. Uhrlaß S. Spread of terbinafine-resistant trichophyton mentagrophytes type VIII (India) in Germany–“The tip of the iceberg?”. J. Fungi 2020 6 4 207 10.3390/jof6040207 33027904
    [Google Scholar]
  42. Shen J.J. Arendrup M.C. Verma S. Saunte D.M.L. The emerging terbinafine-resistant trichophyton epidemic: What is the role of antifungal susceptibility testing? Dermatology 2022 238 1 60 79 10.1159/000515290 34058736
    [Google Scholar]
  43. Vitiello A. Ferrara F. Boccellino M. Ponzo A. Cimmino C. Comberiati E. Zovi A. Clemente S. Sabbatucci M. Antifungal drug resistance: An emergent health threat. Biomedicines 2023 11 4 1063 10.3390/biomedicines11041063 37189681
    [Google Scholar]
  44. Wiederhold N. Antifungal resistance: Current trends and future strategies to combat. Infect. Drug Resist. 2017 10 249 259 10.2147/IDR.S124918 28919789
    [Google Scholar]
  45. Anton A. Plinet M. Peyret T. Cazaudarré T. Pesant S. Rouquet Y. Tricoteaux M.A. Bernier M. Bayette J. Fournier R. Marguerettaz M. Rolland P. Bayol T. Abbaoui N. Berry A. Iriart X. Cassaing S. Chauvin P. Bernard E. Fabre R. François J.M. Rapid and accurate diagnosis of dermatophyte infections using the DendrisCHIP® technology. Diagnostics 2023 13 22 3430 10.3390/diagnostics13223430 37998565
    [Google Scholar]
  46. Dehghan P. Arammehr A. Chadeganipour M. Katoueezadeh M. Shadzi S. Detection of dermatophytes from dermatophytosis-suspected cases in Iran, evaluation of polymerase chain reaction-sequencing method. Adv. Biomed. Res. 2020 9 1 56 10.4103/abr.abr_21_20 33457339
    [Google Scholar]
  47. Gräser Y. Saunte D. A hundred years of diagnosing superficial fungal infections: Where do we come from, where are we now and where would we like to go? Acta Derm. Venereol. 2020 100 9 adv00111 adv00224 10.2340/00015555‑3467 32207536
    [Google Scholar]
  48. Rogers T. Verweij P. Castanheira M. Dannaoui E. White P. Arendrup M. C. Arendrup M. Arikan‐Akdagli S. Barchiesi F. Buil J. Castanheira M. Chryssanthou E. Friberg N. Guinea J. Hamal P. Hilmarsdottir I. Klimko N. Kurzai O. Lagrou K. Rogers T. Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical implications. J Antimicrob Chemother 2022 77 8 2053 2073 10.1093/jac/dkac161
    [Google Scholar]
  49. Nafea A.M. Wang Y. Wang D. Salama A.M. Aziz M.A. Xu S. Tong Y. Application of next-generation sequencing to identify different pathogens. Front. Microbiol. 2024 14 1329330 10.3389/fmicb.2023.1329330 38348304
    [Google Scholar]
  50. Pospischil I. Reinhardt C. Bontems O. Salamin K. Fratti M. Blanchard G. Chang Y.T. Wagner H. Hermann P. Monod M. Hoetzenecker W. Guenova E. Identification of dermatophyte and non-dermatophyte agents in onychomycosis by PCR and DNA sequencing—a retrospective comparison of diagnostic tools. J. Fungi 2022 8 10 1019 10.3390/jof8101019 36294584
    [Google Scholar]
  51. Yamada T. Maeda M. Alshahni M.M. Tanaka R. Yaguchi T. Bontems O. Salamin K. Fratti M. Monod M. Terbinafine resistance of trichophyton clinical isolates caused by specific point mutations in the squalene epoxidase gene. Antimicrob. Agents Chemother. 2017 61 7 e00115-17 10.1128/AAC.00115‑17 28416557
    [Google Scholar]
  52. Voljč M. Dermatophyte infections in humans: Current trends and future prospects CRC Press 2015 3 27
    [Google Scholar]
  53. Satam H. Joshi K. Mangrolia U. Waghoo S. Zaidi G. Rawool S. Thakare R.P. Banday S. Mishra A.K. Das G. Malonia S.K. Next-generation sequencing technology: Current trends and advancements. Biology 2023 12 7 997 10.3390/biology12070997 37508427
    [Google Scholar]
  54. Garcia-Effron G. Molecular markers of antifungal resistance: Potential uses in routine practice and future perspectives. J. Fungi 2021 7 3 197 10.3390/jof7030197 33803304
    [Google Scholar]
  55. Fisher M.C. Alastruey-Izquierdo A. Berman J. Bicanic T. Bignell E.M. Bowyer P. Bromley M. Brüggemann R. Garber G. Cornely O.A. Gurr S.J. Harrison T.S. Kuijper E. Rhodes J. Sheppard D.C. Warris A. White P.L. Xu J. Zwaan B. Verweij P.E. Tackling the emerging threat of antifungal resistance to human health. Nat. Rev. Microbiol. 2022 20 9 557 571 10.1038/s41579‑022‑00720‑1 35352028
    [Google Scholar]
  56. Ayatollahi Mousavi S.A. Mokhtari A. Barani M. Izadi A. Amirbeigi A. Ajalli N. Amanizadeh A. Hadizadeh S. Advances of liposomal mediated nanocarriers for the treatment of dermatophyte infections. Heliyon 2023 9 8 e18960 10.1016/j.heliyon.2023.e18960 37583758
    [Google Scholar]
  57. Okeke I.N. Ihekweazu C. The importance of molecular diagnostics for infectious diseases in low-resource settings. Nat. Rev. Microbiol. 2021 19 9 547 548 10.1038/s41579‑021‑00598‑5 34183821
    [Google Scholar]
  58. Taghipour S. Shamsizadeh F. Pchelin I. Rezaei-Matehhkolaei A. Zarei Mahmoudabadi A. Valadan R. Ansari S. Katiraee F. Pakshir K. Zomorodian K. Abastabar M. Emergence of terbinafine resistant trichophyton mentagrophytes in Iran, harboring mutations in the squalene epoxidase (SQLE) gene. Infect. Drug Resist. 2020 13 845 850 10.2147/IDR.S246025 32214830
    [Google Scholar]
  59. Alabi P.E. Gautier C. Murphy T.P. Gu X. Lepas M. Aimanianda V. Sello J.K. Ene I.V. Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates. MBio 2023 14 4 e00479-23 10.1128/mbio.00479‑23 37326546
    [Google Scholar]
  60. Hossain C. M. Ryan L. K. Gera M. Choudhuri S. Lyle N. Ali K. A. Diamond G. Antifungals and drug resistance. Encyclopedia 2022 2 4 1722 1737
    [Google Scholar]
  61. Bao Y. Wan Z. Li R. In vitro antifungal activity of micafungin and caspofungin against dermatophytes isolated from China. Mycopathologia 2013 175 1-2 141 145 10.1007/s11046‑012‑9571‑6 22983900
    [Google Scholar]
  62. Su H. Jiang W. Verweij P.E. Li L. Zhu J. Han J. Zhu M. Deng S. The in vitro activity of echinocandins against clinical trichophyton rubrum isolates and review of the susceptibility of T. rubrum to echinocandins worldwide. Infect. Drug Resist. 2023 16 5395 5403 10.2147/IDR.S423735 37621698
    [Google Scholar]
  63. Poddar S. Das A. Hay R.J. Wollina U. Newer therapies in dermatophytosis. Indian J. Dermatol. 2023 68 5 515 519 10.4103/ijd.ijd_829_23 38099134
    [Google Scholar]
  64. Belcon M.C. Topical versus systemic antibiotics in the treatment of acute superficial skin infections. J. Natl. Med. Assoc. 1979 71 1 63 64 423278
    [Google Scholar]
  65. Mahajan R. Sahoo A.K. Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review. Indian Dermatol. Online J. 2016 7 2 77 86 10.4103/2229‑5178.178099 27057486
    [Google Scholar]
  66. Bay A. Öner A.F. Etlik Ö. Çaksen H. A case of immune thrombocytopenic purpura presenting with recurrent intracranial hemorrhage. Pediatr. Int. 2005 47 1 109 111 10.1111/j.1442‑200x.2005.02014.x 15693880
    [Google Scholar]
  67. Zeichner J.A. New topical therapeutic options in the management of superficial fungal infections. J. Drugs Dermatol. 2015 14 10 Suppl. s35 s41 26461833
    [Google Scholar]
  68. Ward H. Parkes N. Smith C. Kluzek S. Pearson R. Consensus for the treatment of tinea pedis: A systematic review of randomised controlled trials. J. Fungi 2022 8 4 351 10.3390/jof8040351 35448582
    [Google Scholar]
  69. Rajagopalan M. Inamadar A. Mittal A. Miskeen A.K. Srinivas C.R. Sardana K. Godse K. Patel K. Rengasamy M. Rudramurthy S. Dogra S. Expert consensus on the management of dermatophytosis in India (ECTODERM India). BMC Dermatol. 2018 18 1 6 10.1186/s12895‑018‑0073‑1 30041646
    [Google Scholar]
  70. Hay R. Therapy of skin, hair and nail fungal infections. J. Fungi 2018 4 3 99 10.3390/jof4030099 30127244
    [Google Scholar]
  71. Eriksson E. Griffith G.L. Nuutila K. Topical drug delivery in the treatment of skin wounds and ocular trauma using the platform wound device. Pharmaceutics 2023 15 4 1060 10.3390/pharmaceutics15041060 37111546
    [Google Scholar]
  72. Kardas P. Lewek P. Matyjaszczyk M. Determinants of patient adherence: A review of systematic reviews. Front. Pharmacol. 2013 4 91 10.3389/fphar.2013.00091 23898295
    [Google Scholar]
  73. Kvarnström K. Westerholm A. Airaksinen M. Liira H. Factors contributing to medication adherence in patients with a chronic condition: A scoping review of qualitative research. Pharmaceutics 2021 13 7 1100 10.3390/pharmaceutics13071100 34371791
    [Google Scholar]
  74. Vahedi-Shahandashti R. Lass-Flörl C. Novel antifungal agents and their activity against aspergillus species. J. Fungi 2020 6 4 213 10.3390/jof6040213 33050302
    [Google Scholar]
  75. Szymański M. Chmielewska S. Czyżewska U. Malinowska M. Tylicki A. Echinocandins – Structure, mechanism of action and use in antifungal therapy. J. Enzyme Inhib. Med. Chem. 2022 37 1 876 894 10.1080/14756366.2022.2050224 35296203
    [Google Scholar]
  76. Ivanov M. Ćirić A. Stojković D. Emerging antifungal targets and strategies. Int. J. Mol. Sci. 2022 23 5 2756 10.3390/ijms23052756 35269898
    [Google Scholar]
  77. Nami S. Aghebati-Maleki A. Aghebati-Maleki L. Current applications and prospects of nanoparticles for antifungal drug delivery. EXCLI J. 2021 20 562 584 33883983
    [Google Scholar]
  78. Bila N.M. Costa-Orlandi C.B. Vaso C.O. Bonatti J.L.C. de Assis L.R. Regasini L.O. Fontana C.R. Fusco-Almeida A.M. Mendes-Giannini M.J.S. 2-Hydroxychalcone as a potent compound and photosensitizer against dermatophyte biofilms. Front. Cell. Infect. Microbiol. 2021 11 679470 10.3389/fcimb.2021.679470 34055673
    [Google Scholar]
  79. Lyon J.P. de Maria Pedroso e Silva Azevedo C. Moreira L.M. de Lima C.J. de Resende M.A. Photodynamic antifungal therapy against chromoblastomycosis. Mycopathologia 2011 172 4 293 297 10.1007/s11046‑011‑9434‑6 21643843
    [Google Scholar]
  80. Mehta D. Saini V. Bajaj A. Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance. RSC Medicinal Chemistry 2023 14 9 1603 1628 10.1039/D3MD00151B 37731690
    [Google Scholar]
  81. Sousa F. Ferreira D. Reis S. Costa P. Current insights on antifungal therapy: Novel nanotechnology approaches for drug delivery systems and new drugs from natural sources. Pharmaceuticals 2020 13 9 248 10.3390/ph13090248 32942693
    [Google Scholar]
  82. Wu X. Hu Y. Photodynamic therapy for the treatment of fungal infections. Infect. Drug Resist. 2022 15 3251 3266 10.2147/IDR.S369605 35761978
    [Google Scholar]
  83. Vaou N. Stavropoulou E. Voidarou C. Tsigalou C. Bezirtzoglou E. Towards advances in medicinal plant antimicrobial activity: A review study on challenges and future perspectives. Microorganisms 2021 9 10 2041 10.3390/microorganisms9102041 34683362
    [Google Scholar]
  84. Rex J.H. Pfaller M.A. Galgiani J.N. Bartlett M.S. Espinel-Ingroff A. Ghannoum M.A. Lancaster M. Odds F.C. Rinaldi M.G. Walsh T.J. Barry A.L. Development of interpretive breakpoints for antifungal susceptibility testing: Conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and candida infections. Clin. Infect. Dis. 1997 24 2 235 247 10.1093/clinids/24.2.235 9114154
    [Google Scholar]
  85. Czajka K.M. Venkataraman K. Brabant-Kirwan D. Santi S.A. Verschoor C. Appanna V.D. Singh R. Saunders D.P. Tharmalingam S. Molecular mechanisms associated with antifungal resistance in pathogenic candida species. Cells 2023 12 22 2655 10.3390/cells12222655 37998390
    [Google Scholar]
  86. Mali R. Patil J. Nanoparticles: A novel antifungal drug delivery system Mater. Proc. 2023 14 1 61
    [Google Scholar]
  87. Hassoun N. Kassem I.I. Hamze M. El Tom J. Papon N. Osman M. Antifungal use and resistance in a lower–middle-income country: The case of Lebanon. Antibiotics 2023 12 9 1413 10.3390/antibiotics12091413 37760710
    [Google Scholar]
  88. Ohmann C. Banzi R. Canham S. Battaglia S. Matei M. Ariyo C. Becnel L. Bierer B. Bowers S. Clivio L. Dias M. Druml C. Faure H. Fenner M. Galvez J. Ghersi D. Gluud C. Groves T. Houston P. Karam G. Kalra D. Knowles R.L. Krleža-Jerić K. Kubiak C. Kuchinke W. Kush R. Lukkarinen A. Marques P.S. Newbigging A. O’Callaghan J. Ravaud P. Schlünder I. Shanahan D. Sitter H. Spalding D. Tudur-Smith C. van Reusel P. van Veen E.B. Visser G.R. Wilson J. Demotes-Mainard J. Sharing and reuse of individual participant data from clinical trials: Principles and recommendations. BMJ Open 2017 7 12 e018647 10.1136/bmjopen‑2017‑018647 29247106
    [Google Scholar]
  89. Ghannoum M. Azole resistance in dermatophytes. J. Am. Podiatr. Med. Assoc. 2016 106 1 79 86 10.7547/14‑109 26895366
    [Google Scholar]
  90. Blanchard G. Amarov B. Fratti M. Salamin K. Bontems O. Chang Y.T. Sabou A.M. Künzle N. Monod M. Guenova E. Reliable and rapid identification of terbinafine resistance in dermatophytic nail and skin infections. J. Eur. Acad. Dermatol. Venereol. 2023 37 10 2080 2089 10.1111/jdv.19253 37319111
    [Google Scholar]
  91. Ebert A. Monod M. Salamin K. Burmester A. Uhrlaß S. Wiegand C. Hipler U.C. Krüger C. Koch D. Wittig F. Verma S.B. Singal A. Gupta S. Vasani R. Saraswat A. Madhu R. Panda S. Das A. Kura M.M. Kumar A. Poojary S. Schirm S. Gräser Y. Paasch U. Nenoff P. Alarming India‐wide phenomenon of antifungal resistance in dermatophytes: A multicentre study. Mycoses 2020 63 7 717 728 10.1111/myc.13091 32301159
    [Google Scholar]
  92. Mahajan S. Tilak R. Kaushal S. Mishra R. Pandey S. Clinico-mycological study of dermatophytic infections and their sensitivity to antifungal drugs in a tertiary care center. Indian J. Dermatol. Venereol. Leprol. 2017 83 4 436 440 10.4103/ijdvl.IJDVL_519_16 28540871
    [Google Scholar]
  93. Van Tro C. Ho Thi Ngoc K. Nguyen Van T. Tran Hau K. Gandolfi M. Satolli F. Feliciani C. Tirant M. Vojvodic A. Lotti T. Antifungal susceptibility of dermatophytes isolated from cutaneous fungal infections: The Vietnamese experience. Open Access Maced. J. Med. Sci. 2019 7 2 247 249 10.3889/oamjms.2019.062 30745971
    [Google Scholar]
  94. Goh C.L. Tay Y.K. Bin Ali K. Koh M.T. Seow C.S. In vitro evaluation of griseofulvin, ketoconazole, and itraconazole against various dermatophytes in Singapore. Int. J. Dermatol. 1994 33 10 733 737 10.1111/j.1365‑4362.1994.tb01523.x 8002147
    [Google Scholar]
  95. Khalifa H.O. Arai T. Majima H. Watanabe A. Kamei K. Genetic basis of azole and echinocandin resistance in clinical candida glabrata in Japan. Antimicrob. Agents Chemother. 2020 64 9 e00783-20 10.1128/AAC.00783‑20 32571826
    [Google Scholar]
  96. Naicker S.D. Shuping L. Zulu T.G. Mpembe R.S. Mhlanga M. Tsotetsi E.M. Maphanga T.G. Govender N.P. Black J. Pearce V. Hoosen A. Kleinhans V. Karstaedt A. Maluleka C. Verwey C. Feldman C. Moore D. Reubenson G. Han K.S.S. Wadula J. Nel J. Lindeque K. Nchabeleng M. Samodien N. du Plessis N. Bosman N. Kularatne R. Seetharam S. Thomas T. Avenant T. Nana T. Chibabhai V. Maharj A. Burra A. Naby F. Dawood H. Mogamberry J. Mlisana K. Sookan L. Ramjathan P. Mahabeer P. Naidoo R. Haffejee S. Coovadia Y. Hamese K. Sibiya N. Lekalakala R. Hoyland G. Lebudi J. Jooste P. Variava E. du Plessis E. Whitelaw A. Reddy K. Nicol M. Naicker P. Brink A. Prentice E. Zietsman I. Botha M. Smith P. Poswa X. Govind C. Pillay K. Budavari S. Haumann C. Samuel C. Senekal M. Dreyer A. Ahmed K. Marcus L. Lowman W. Messina A. van den Bergh D. Swart K. Whitney C. Klugman K. Nanoo A. Dreyer A. von Gottberg A. Smith A. Sooka A. Miller C. Sriruttan C. Cohen C. Ihekweazu C. von Mollendorf C. du Plessis D. Britz E. Radebe F. Ntshoe G. Hunt G. Mathema H. Weyer J. Rossouw J. Frean J. Keddy K. McCarthy K. de Gouveia L. Erasmus L. Blumberg L. Smith M. Makgoba M. Modise M. Ismail N. Govender N. Legare N. Page N. Ramalwa N. Paulse N. Vazi P. Perovic O. Crowther-Gibson P. Mutevedzi P. Manesen R. Mpembe R. Lengana S. Madhi S. Walaza S. Lindani S. Njikho S. Meiring S. Motladiile T. Lebaka T. Quan V. Chetty V. Epidemiology and susceptibility of Nakaseomyces (formerly Candida ) glabrata bloodstream isolates from hospitalised adults in South Africa. Med. Mycol. 2023 61 6 myad057 10.1093/mmy/myad057 37336590
    [Google Scholar]
/content/journals/crcep/10.2174/0127724328328331241217194034
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Breaking the Mold: Advances and Hurdles in Antifungal Resistance Management for Dermatophytes
Bentham Science Publishers ; https://doi.org/10.2174/0127724328328331241217194034
/content/journals/crcep/10.2174/0127724328328331241217194034
/content/journals/crcep/10.2174/0127724328328331241217194034
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  • Article Type:     Review Article
Keywords: dermatophytes ; clinical microbiology ; infectious diseases ; Antifungal resistance

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