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- Volume 27, Issue 25, 2021
Current Pharmaceutical Design - Volume 27, Issue 25, 2021
Volume 27, Issue 25, 2021
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Quorum Sensing - A Stratagem for Conquering Multi-Drug Resistant Pathogens
Authors: Madison Tonkin, Shama Khan, Mohmmad Y. Wani and Aijaz AhmadQuorum sensing is defined as a cell to cell communication between micro-organisms, which enables micro-organisms to behave as multicellular organisms. Quorum sensing enables many collaborative benefits such as synchronisation of virulence factors and biofilm formation. Both quorum sensing, as well as biofilm formation, encourage the development of drug resistance in micro-organisms. Biofilm formation and quorum Read More
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Phytochemicals for Drug Discovery in Alzheimer’s Disease: In Silico Advances
Authors: Smriti Sharma and Vinayak BhatiaThe search for novel drugs that can prevent or control Alzheimer’s disease has attracted a lot of attention from researchers across the globe. Phytochemicals are increasingly being used to provide scaffolds to design drugs for AD. In silico techniques have proven to be a game-changer in this drug design and development process. In this review, the authors have focussed on current advances in the field of in silico medicin Read More
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Recent Advances in Pharmacological Interventions of Chronic Prostatitis/ Chronic Pelvic Pain Syndrome
Authors: Nasrin Aktar, Ahmed Moudud, Tingting Chen, Xiaoqing Gao, Hanhui Min, Meng Tang and Xiaohui ZhouChronic prostatitis/chronic pelvic pain syndrome type III is related to irritative voiding, sexual dysfunction, and pelvic pain. Chronic prostatitis/chronic pelvic pain syndrome weakens the quality of life and poses adverse psychological effects on the patients. A wide range of treatments, including botulinum neurotoxins, anti-inflammatories, alpha-blockers, phytotherapy, 5α-reductase inhibitors, phosphodiester Read More
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Tablet Formulation of a Synthesized Celecoxib Potassium Salt and Development of a Validated Method for Its Analysis
Authors: Murad Abualhasan, Nidal Zatar, Kefah A. Shehab and Nasr ShraimBackground: Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) and cyclooxygenase-2 (COX-2) inhibitor. It is used for the treatment of rheumatoid arthritis, osteoarthritis, juvenile arthritis, and acute pain. Celecoxib has low systemic bioavailability due to its low water solubility. This study aimed to improve water solubility and dissolution profile by synthesizing a suitable celecoxib potassium salt (celecoxib–K salt). Met Read More
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The Molecular Targets of Cannabinoids in the Treatment of Cancer and Inflammation
Authors: Alenabi Aylar and Malekinejad HassanObjective: In this review, we discuss the emerging evidence for the effectiveness of cannabinoids in the treatment of cancer and inflammation. The remarkable effects of this study will help in supporting the traditional evidence for their successful application in the treatment of pain and cancer-related side effects. Methods: We searched Pub Med (132 articles) and Google scholar (9 articles) databases and gathered the clinical (4 Read More
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Different Methods for Molecular and Rapid Detection of Human Novel Coronavirus
Authors: Mohamad H. Shahrajabian, Wenli Sun and Qi ChengIntroduction: While PCR has been recognized as one of the appropriate ways to diagnose infectious diseases, Loop-mediated isothermal amplification (LAMP) which is a nucleic acid amplification method, can be considered as an alternative to PCR, and it is faster, cost-effective, and easier to perform than nested PCR. Patients and Methods: Keywords were searched in PubMed/MEDLINE, Scopus and Institute for Scienti Read More
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An Overview of Nano Delivery Systems for Targeting RNA Interference-based Therapy in Ulcerative Colitis
Ulcerative colitis (UC) is one of the main subtypes of inflammatory bowel disease. UC has a negative effect on patients’ quality of life, and it is an important risk factor for the development of colitis-associated cancer. Patients with UC need to take medications for their entire life because no permanent cure is available. Therefore, approaches that target messenger RNA (mRNA) of proinflammatory cytokines and/or anti-infla Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
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- Issue 27
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- Issue 21
- Issue 20
- Issue 19
- Issue 18
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- Issue 16
- Issue 15
- Issue 14
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- Issue 12
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- Issue 10
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- Issue 4
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- Issue 6
- Issue 5
- Issue 3
- Issue 2
- Issue 1
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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