Current Pharmaceutical Design - Volume 27, Issue 35, 2021

Long non-coding RNAs (lncRNAs) are functionally versatile molecules that regulate gene expression at all levels of biological organization. RNA modulation, at the moment, has emerged as a powerful therapeutic technique to treat human diseases. Lately, lncRNAs have been acknowledged as key players in human metabolism and, indeed, implicated in the etiology of many common diseases other than cancers, where they c Read More

Breast cancer is the most common type of malignancy affecting women worldwide and also stands being the most diagnosed one. Mammography is considered as the golden standard for diagnosis but there are high chances that it can give false- negative as well as false-positive test results. Finding cost-effective, readily available diagnosis along with increased sensitivity as well as specificity is the need right now to decrease t Read More

Background: Inflammatory bowel disease (IBD) is a multifactorial condition influenced by the immune system, the intestinal microbiota, environmental factors, genetic and epigenetic factors. Genetic- and environment- induced dysregulation of the Nuclear Factor-kappa B (NF-ΚB) transcription factor pathway has been linked to IBD pathogenesis. Objective: To assess the current evidence in relation to the contributio Read More

Extracellular vesicles (EVs, formerly known as exosomes) are small, extracellular membrane-bound particles that play a role in cellular communication via transporting different cargos, including proteins, DNAs, RNAs, etc. Their role has been shown in different endocrine/paracrine signaling in different organs, such as the cardiovascular system. Currently, mortality and morbidity rates caused by cardiovascular disea Read More

Hypertension is a common chronic disease that particularly affects the elderly and can trigger several cardiovascular conditions. Although the treatment of hypertension has evolved in recent decades, many hypertensive patients still do not have properly controlled blood pressure. Accumulating evidence supports the hypothesis that DNA methylation plays an important role in regulating gene expression, altering the Read More

Background: Metabolic syndrome is a clinical condition that deserves special attention because it puts the individual at high cardiovascular risk, especially heart attack and stroke. Considering precision medicine, it would be advisable to evaluate the individual cardio-metabolic risk by estimating the coexistence of risk factors (abdominal obesity, low level of High-Density Lipoprotein Cholesterol, High Triglycerides, and s Read More

Background: Molecular genetic mechanisms, signaling pathways, conditions, factors, and markers of the osteogenic differentiation of mesenchymal stem cells (MSCs) are being actively studied and are among the most studied areas in the field of cellular technology. This attention is largely due to the mounting contradictions in the seemingly classical knowledge and the constant updating of results in the analyzed areas. In this rega Read More