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- Volume 27, Issue 15, 2021
Current Pharmaceutical Design - Volume 27, Issue 15, 2021
Volume 27, Issue 15, 2021
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Quinoline-based Compounds as Key Candidates to Tackle Drug Discovery Programs of Microbicidal Agents
Authors: Aline N. Silva da Gama and Maria N.C. SoeiroQuinolines are heterocyclic nitrogen compounds, ubiquitous in nature and largely used as a structural component of dyes, solvent for resins, terpenes as well as during the production of several other chemical stuffs, including pesticides. Quinolines, such as quinine and chloroquine, exhibit various pharmacological properties, acting as antimalarial drugs, antiparasitic, antibacterial, antiviral, antifungal, and anticancer agents, Read More
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Metallodrugs for the Treatment of Trypanosomatid Diseases: Recent Advances and New Insights
Authors: Maribel Navarro, Rodrigo M.S. Justo, Giset Y. Sánchez Delgado and Gonzalo VisbalTrypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs). NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and subtropical areas of Africa, Asia, and the Americas. The three major human diseases caused by trypanosomatids are African trypanosomiasis, Chagas disease and leishmaniasis. There are known drugs for the treatment of these dise Read More
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Phospholipid Analogues as Chemotherapeutic Agents Against Trypanosomatids
More LessBackground: Neglected tropical diseases (NTDs) represent a serious problem in a number of countries around the world and especially in Africa and South America, affecting mostly the poor population which has limited access to the healthcare system. The drugs currently used for the treatment of NTDs are dated many decades ago and consequently, present in some cases very low efficacy, high toxicity and development of drug Read More
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Naphthoquinones and Derivatives for Chemotherapy: Perspectives and Limitations of their Anti-trypanosomatids Activities
Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively, are considered neglected tropical diseases, and they especially affect impoverished populations in the developing world. The available chemotherapies are very limited, and a search for alternatives is still necessary. In folk medicine, natural naphthoquinones have been e Read More
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The Rationale for Use of Amiodarone and its Derivatives for the Treatment of Chagas’ Disease and Leishmaniasis
Authors: Gustavo Benaim, Alberto E. Paniz-Mondolfi and Emilia M. SordilloThe repurposing or repositioning of previously-approved drugs has become an accepted strategy for the expansion of the pharmacopeia for neglected diseases. Accordingly, amiodarone, an inexpensive and extensively- used class III antiarrhythmic has been proposed as a treatment for Chagas’ disease and leishmaniasis. Amiodarone has a potent trypanocidal and leishmanicidal action, mainly acting through the disruptio Read More
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Trypanothione Metabolism as Drug Target for Trypanosomatids
Authors: María D. Piñeyro, Diego Arias, Adriana Parodi-Talice, Sergio Guerrero and Carlos RobelloChagas Disease, African sleeping sickness, and leishmaniasis are neglected diseases caused by pathogenic trypanosomatid parasites, which have a considerable impact on morbidity and mortality in poor countries. The available drugs used as treatment have high toxicity, limited access, and can cause parasite drug resistance. Long-term treatments, added to their high toxicity, result in patients that give up therapy. Trypanosomat Read More
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Sequence-Based Deep Learning Frameworks on Enhancer-Promoter Interactions Prediction
Authors: Xiaoping Min, Fengqing Lu and Chunyan LiEnhancer-promoter interactions (EPIs) in the human genome are of great significance to transcriptional regulation, which tightly controls gene expression. Identification of EPIs can help us better decipher gene regulation and understand disease mechanisms. However, experimental methods to identify EPIs are constrained by funds, time, and manpower, while computational methods using DNA sequences and genom Read More
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Generative Adversarial Networks in Medical Image Processing
Authors: Meiqin Gong, Siyu Chen, Qingyuan Chen, Yuanqi Zeng and Yongqing ZhangBackground: The emergence of generative adversarial networks (GANs) has provided new technology and framework for the application of medical images. Specifically, a GAN requires little to no labeled data to obtain high-quality data that can be generated through competition between the generator and discriminator networks. Therefore, GANs are rapidly proving to be a state-of-the-art foundation, achieving enhanced perf Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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