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- Volume 27, Issue 24, 2021
Current Pharmaceutical Design - Volume 27, Issue 24, 2021
Volume 27, Issue 24, 2021
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Suppression of Spermatogenesis by Exogenous Testosterone
Authors: Ferdinando Fusco, Paolo Verze, Marco Capece and Luigi NapolitanoSperm production starts from puberty in the seminiferous tubules providing testosterone production by the Leydig cells that takes place in the interstice of the testicles. Normal spermatogenesis depends on specific signalling from the hypothalamic-pituitary-gonadal axis. GnRH, FSH and LH are the main hormones involved in the production and maturation of spermatozoa. Exogenous administration of androgens influences t Read More
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GnRH in the Treatment of Hypogonadotropic Hypogonadism
Authors: Carlo Bettocchi, Marco Rinaldi and Francesco SebastianiGonadotropin-releasing hormone (GnRH) is the focus of the scientific debate for the treatment of hypogonadotropic hypogonadism. Sexual maturation and reproductive function depend on the pulsatile secretion of GnRH that are mainly congenital and may or may not be associated with other genetic anomalies or syndromes. Clinical manifestations include a wide range of metabolic, endocrine, and psychologic dysfunctio Read More
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Therapeutic Effects of Micronutrient Supplements on Sperm Parameters: Fact or Fiction?
Background: Despite the limited evidence about the effect of micronutrient supplementation on the semen quality, many micronutrient supplements have been used to improve male fertility. Approximately, 40%- 50% of male infertility cases in general and up to 80% in men with idiopathic infertility cases are caused by oxidative stress and decreased level of seminal total antioxidant capacity. Objective: To investig Read More
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Hormonal Male Contraception
More LessThe demand for availability of efficient and safe contraceptive methods is strengthened by the predictions made by the United Nations regarding the future growth of the human population. So far, women are not only the main victims of the unsafe procedures related to terminating unwished pregnancies but do also carry the main responsibility for family planning. There is a significant desire among men for sharing this respo Read More
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Gonadotropin Treatment for the Male Hypogonadotropic Hypogonadism
Authors: Luca Boeri, Paolo Capogrosso and Andrea SaloniaHypogonadotropic hypogonadism (HH) is caused by a dysfunction in the hypothalamus and/or the pituitary gland and it can be congenital or acquired. This condition is biochemically characterized by low or inappropriately normal gonadotropin levels along with low total testosterone levels. If fertility is not an issue, testosterone therapy is the treatment of choice to induce and maintain secondary sexual characteristics Read More
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The Role of Nitric oxide (NO) Donors in the Treatment of Male Infertility
Authors: Edoardo Pozzi, Omer O. Cakir and Asif MuneerMale infertility is a global problem and the number of men suffering from this condition has increased dramatically over the last decade. Currently, approximately 10–15% of couples have been affected by this worldwide. Although this is a crucial problem, treatment options are limited and sometimes even ineffective. In order to arrest this worrisome increase, the development of new treatment strategies has become funda Read More
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Hypergonadotropic Hypogonadism: Management of Infertility
Authors: Arif Kalkanli, Hakan Akdere, Gökhan Cevik, Emre Salabas, Nusret C. Cilesiz and Ateş KadiogluBackground: Medical treatments are used either alone or in combination with assisted reproductive techniques for the treatment of infertile patients with hypergonadotropic hypogonadism. A wide range of treatment options such as gonadotropins, aromatase inhibitors (AIs), selective estrogen receptor modulators (SERMs) and their combination are available as options. Objective: The aim of this review was to evaluate Read More
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Administration of Antioxidants in Infertile Male: When it may have a Detrimental Effect?;
Background & Objective: Significant advances in the field of male infertility have been witnessed during the last years. Given the well-known detrimental effects of reactive oxygen species (ROS), the administration of antioxidants has emerged as a promising solution for oxidative stress (OS)-induced male infertility. Nevertheless, this perception seems largely oversimplified, and the existing literature fails to recognize a n Read More
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Microglia NLRP3 Inflammasomes Activation Involving Diabetic Neuroinflammation in Diabetic Mice and BV2 Cells
Authors: Yuan Li, Haifeng Zhang, Mingyuan Liu, Weiying Guo and Lu YuBackground: Hyperglycemia-induced microglia activation can cause a continuous release of proinflammatory cytokines, which gradually damages neurons and contributes to central diabetic neuroinflammation. Objective: This study aimed to illustrate the possible mechanism related to NLRP3 inflammasome and the aggravation of diabetes neuroinflammation. Methods: The targeted proteins from BV2 cells and brain tissues we Read More
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Comprehensive DNA Methylation-transcriptome Profiles Association Analysis During the Treatment of Acute Myelocytic Leukemia
Authors: Jun Wu, Ming-Zhu Song, Li-Jun Deng and Qian-Ling YeBackground: Epigenetic modifications have recently attracted much attention in the study of the biological mechanisms of Acute Myelocytic Leukemia (AML) for therapy and prognosis. However, studies on DNA methylation changes during AML treatment are limited. Objective: The comprehensive DNA methylation-transcriptome profiles association analysis in this study aimed to establish whole-genome DNA methyla Read More
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A Three-gene-based Type 1 Diabetes Diagnostic Signature
Authors: Rongrong Wang, Yanan Zhou, Yan Zhang, Shaoqing Li, Runzhou Pan and Yongcai ZhaoBackground: Type 1 diabetes is a chronic autoimmune disease featured by insulin deprivation caused by pancreatic β-cell loss, followed by hyperglycaemia. Objective: Currently, there is no cure for this disease in clinical treatment, and patients have to accept a lifelong injection of insulin. The exploration of potential diagnosis biomarkers through analysis of mass data by bioinformatics tools and machine learning is i Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
- Issue 46
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- Issue 44
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- Issue 4
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- Issue 3
- Issue 2
- Issue 1
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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