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- Volume 24, Issue 40, 2018
Current Pharmaceutical Design - Volume 24, Issue 40, 2018
Volume 24, Issue 40, 2018
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A Comprehensive Review of Oxidative Stress as the Underlying Mechanism in Atherosclerosis and the Inefficiency of Antioxidants to Revert this Process
Authors: Kevin G. Cabezas, Carmen R. Gómez-Fernandez and Roberto Vazquez-PadronBackground: Cardiovascular diseases account for the highest mortality rate in the United States. The major underlying mechanism driving the onset and maintenance of cardiovascular diseases is atherosclerosis. Atherosclerosis is a chronic disease affecting large and medium-size arteries; it proceeds through four main stages along different decades of life, beginning at birth. Atherosclerosis is a consequence of oxidative stre Read More
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Oxidative Stress and Accelerated Aging in Neurodegenerative and Neuropsychiatric Disorder
Authors: Ridhima Wadhwa, Riya Gupta and Pawan K. MauryaBackground: Neurodegenerative diseases are becoming more and more common in today’s world. As people are continuously being exposed to exogenous factors like UV radiations, gamma rays, X-Rays, environmental pollutants and heavy metals, the cases of increased oxidative damage are increasing. Even though some amount of oxidative damage occurs in all metabolic reactions but their increase from the normal leve Read More
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Oxidative Stress, Ocular Disease and Diabetes Retinopathy
Authors: Orathai Tangvarasittichai and Surapon TangvarasittichaiBackground: Oxidative stress is caused by free radicals or oxidant productions, including lipid peroxidation, protein modification, DNA damage and apoptosis or cell death and results in cellular degeneration and neurodegeneration from damage to macromolecules. Results: Accumulation of the DNA damage (8HOdG) products and the end products of LPO (including aldehyde, diene, triene conjugates and Schiff’s bases) were note Read More
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Endothelial Activation and Oxidative Stress in Neurovascular Defects of the Retina
Authors: Raji Lenin, Samuel M. Thomas and Rajashekhar GangarajuBackground: The eye is considered as a window of the disease, and a better understanding of neurodegenerative changes in the eye may help diagnose and manage neurodegenerative diseases including the diseases of brain, heart, kidney and liver. In the eye, the blood retinal barrier (BRB] is maintained by a combination of endothelial cells, pericytes, and glia. This BRB integrity is fundamental to the physiology of retin Read More
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Oxidative Stress and the Epigenetics of Cell Senescence: Insights from Progeroid Syndromes
Background: Cell senescence constitutes a critical process to respond to a variety of insults and adverse circumstances. Senescence involves the detention of DNA replication and cell proliferation, and hence, genetic programs associated with DNA damage response, chromosome stability, chromatin rearrangement, epigenetic reprogramming, and cell cycle are tightly linked to the senescent phenotype. Although senescenc Read More
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Oxidative Stress and Cancer
More LessBackground: Cancer is considered a major cause of death worldwide. The etiology of cancer is linked to environmental and genetic inheritance causes. Approximately 90 percent of all human cancers have an environmental cause (non-genetic inheritance) predominantly through lifestyle choices (smoking, diet, UV radiation) while the remaining due to infections and chemical exposure. Cancer is a multistage process that i Read More
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Cruciferous Vegetables as Antioxidative, Chemopreventive and Antineoplasic Functional Foods: Preclinical and Clinical Evidences of Sulforaphane Against Prostate Cancers
Background: Sulforaphane (SF, 1-isothiocyanato-4-(methyl-sulfinyl)-butane) is found in broccoli, cabbage and cauliflower. Methods: we performed a critical review on the antioxidative, chemopreventive and antitumor effects of SF from cruciferous vegetables against prostate cancers and molecular pathways. For a complete and reliable review, primary and secondary resources were used, including original and review arti Read More
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Oxidative Stress and Kidney Function: A Brief Update
Authors: Giuseppe Coppolino, Giuseppe Leonardi, Michele Andreucci and Davide BolignanoIn this review we summarized some information regarding the link between kidney and oxidative stress. Accruing evidences indicated the kidney as a fundamental organ in reactive oxygen species (ROS) production. ROS are highly reactive and cause in single cells: protein alteration, DNA damage, cellular senescence and apoptosis; while the effect of ROS in biological tissues leads to a harmful oxidation effect on all their bi Read More
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Effects of Nutrients and Exercises to Attenuate Oxidative Stress and Prevent Cardiovascular Disease
Authors: Mario F. Neves, Michelle R. Cunha and Tainah de PaulaBackground: In recent years, it has become more evident that oxidative stress is involved in the development of cardiovascular disease. Indeed, reactive oxygen species seems to be the common mechanism for endothelial dysfunction, vascular inflammation and arterial stiffness, resulting in a blood pressure increase and early vascular aging. Methods: This review presents the potential role of antioxidant nutrients and exercis Read More
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The Biological Significance of Oxidative Stress, Effects of Fruits as Natural Edible Antioxidants
Background: Oxidative stress (OxS) is a biochemical process characterized by an imbalance between the production of reactive species (RS) and antioxidants in favor of the former that subsequently induces the oxidative damage of biomolecules and alters cellular physiology. OxS exerts diverse effects and is associated with the pathophysiology of more than 100 diseases, as well as with the aging process. OxS also plays a Read More
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Known Hepatoprotectors Act as Antioxidants and Immune Stimulators in Stressed Mice: Perspectives in Animal Health Care
More LessBackground: Oxygen is involved in a variety of physiological reactions in aerobic organisms, such as those produced in the electron transport chain, hydroxylation, and oxygenation. Reactive oxygen species (ROS) are naturally formed as byproducts from these previously reactions involving the O2 molecule; they are made up of superoxide anion (O2−), hydroxyl radical (HO−), hydrogen peroxide (H2O2), nitric oxide (NO), peroxy Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
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- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
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- Issue 25
- Issue 24
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- Issue 21
- Issue 20
- Issue 19
- Issue 18
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- Issue 16
- Issue 15
- Issue 14
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- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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