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- Volume 24, Issue 43, 2018
Current Pharmaceutical Design - Volume 24, Issue 43, 2018
Volume 24, Issue 43, 2018
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Nanotechnology: Revolutionizing the Science of Drug Delivery
Authors: Mohini Mishra, Pramod Kumar, Jitendra S. Rajawat, Ruchi Malik, Gitanjali Sharma and Amit ModgilGrowing interest in the field of nanotechnology has led to its emergence in the field of medicine too. Nanomedicines encompass the various medical tools, diagnostic agents and the drug delivery vehicles being evolved with the advancements in the aura of nanotechnology. This review emphasizes on providing a cursory literature on the past events that led to the procession of nanomedicines, various novel drug delivery Read More
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Topical Drug Delivery of Anti-infectives Employing Lipid-Based Nanocarriers: Dermatokinetics as an Important Tool
Authors: Kanika Thakur, Gajanand Sharma, Bhupindar Singh and Om P. KatareBackground: The therapeutic approaches for the management of topical infections have always been a difficult approach due to lack of efficacy of conventional topical formulations, high frequency of topical applications and non-patient compliance. The major challenge in the management of topical infections lies in antibiotic resistance which leads to severe complications and hospitalizations resulting in economic burden and h Read More
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Nanocrystals: An Overview of Fabrication, Characterization and Therapeutic Applications in Drug Delivery
Authors: Vishwas P. Pardhi, Tejesh Verma, S.J.S. Flora, Hardik Chandasana and Rahul ShuklaApproximately 40 % drugs in the market are having poor aqueous solubility related problems and 70 % molecules in discovery pipeline are being practically insoluble in water. Nanocrystals is a prominent tool to solve the issue related to poor aqueous solubility and helps in improving the bioavailability of many drugs as reported in the literature. Nanocrystals can be prepared by top down methods, bottom up methods and Read More
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Advanced Approaches of Bioactive Peptide Molecules and Protein Drug Delivery Systems
Authors: Nagarani Thotakura, Lokesh Kaushik, Vipin Kumar, Simran Preet and Penke V. BabuDespite the fact that protein and peptide therapeutics are widely employed in the treatment of various diseases, their delivery is posing an unembellished challenge to the scientists. It was discovered that delivery of these therapeutic systems through oral route is easy with high patient compliance. However, proteolytic degradation and absorption through the mucosal epithelium are the barriers in this route. These issue Read More
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Advances in Nanoparticle-based Delivery of Next Generation Peptide Nucleic Acids
Authors: Shipra Malik, Brenda Asmara, Zoe Moscato, Jatinder K. Mukker and Raman BahalBackground: Peptide nucleic acids (PNAs) belong to the next generation of synthetic nucleic acid analogues. Their high binding affinity and specificity towards the target DNA or RNA make them the reagent of choice for gene therapy-based applications. Objective: To review important gene therapy based applications of regular and chemically modified peptide nucleic acids in combination with nanotechnology. Method: Read More
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Pharmacokinetic Modeling in Nano-formulations: Concept, Implementation and Challenges
Authors: Jatinder K. Mukker and Ravi S. P. SinghThe properties of nanoparticles can be exploited to overcome challenges in drug delivery. By virtue of its design and size, the pharmacokinetics of nanoparticles are different than other small molecules. Modeling and simulation techniques have great potential to be used in nanoformulation development; however, their use in optimization of nanoformulation is very limited. This review highlights the differences in absorption, Read More
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New Perspectives on the Efficacy of Gallic Acid in Cosmetics & Nanocosmeceuticals
Background: Gallic acid (GA-3,4,5-trihydroxybenzoic acid), a phenolic phytochemical, is a ubiquitous secondary metabolite found in most plants, with appreciable concentrations in grapes seed, rose flowers, sumac, oak and witch hazel. GA often results from the hydrolysis of terpenes and the polyphenol tannic acid. Applications: It exhibits powerful antioxidant, anti-inflammatory, antimicrobial, and anti-cancer activities. Most int Read More
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Potential of Natural Biomaterials in Nano-scale Drug Delivery
Background: The usage of natural biomaterials or naturally derived materials intended for interface with biological systems has steadily increased in response to the high demand of amenable materials, which are suitable for purpose, biocompatible and biodegradable. There are many naturally derived polymers which overlap in terms of purpose as biomaterials but are equally diverse in their applications. Methods: This Read More
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Carbon Nanotubes as A High-Performance Platform for Target Delivery of Anticancer Quinones
Authors: H.V. Grushevskaya and N.G. KrylovaBackground: In spite of considerable efforts of researchers the cancer deseases remain to be incurable and a percentage of cancer deseases in the structure of mortality increases every year. At that, high systemic toxicity of antitumor drugs hampers their effective use. Because of this fact, the development of nanosystems for targeted delivery of antitumor drugs is one of the leading problem in nanomedicine and nanophar Read More
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Recent Interventions for Nanotechnology Based Drug Products: Insights into the Regulatory Aspects
Authors: Amita Sarwal, Gurpreet Singh, Kirti Singh and Sanjay GargBackground : Nanotechnology has been one of the most prominent forefront grounds in several traditional research areas of science and technology, and development of medicines at nanoscale can be reflected by the tremendous surge in market interest. Present outlook: Its applications include various research areas of medicine, drug delivery technology, diagnostic devices, tissue engineering and gene thera Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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