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- Volume 24, Issue 13, 2018
Current Pharmaceutical Design - Volume 24, Issue 13, 2018
Volume 24, Issue 13, 2018
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Adhesive Drug Delivery Systems Based on Polyelectrolyte Complex Nanoparticles (PEC NP) for Bone Healing
Authors: Martin Muller, David Vehlow, Bernhard Torger, Birgit Urban, Beatrice Woltmann and Ute HempelBackground: In this contribution an overview is given on own work concerning drug loaded Polyelectrolyte Complex (PEC) Nanoparticles (NP) used to functionalize Bone Substitute Materials (BSM) for the therapy of bone defects associated with systemic bone diseases. In this context, drug loaded PEC NP have certain advantages, which are exemplarily summarized herein. Methods: Concerning preparative methods PEC NP Read More
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A Review on Oral Liquid as an Emerging Technology in Controlled Drug Delivery System
Authors: Sangmesh R. Torne, Angappan Sheela and N.C. SaradaBackground: The Oral Liquid Drug Delivery System (OLDDS) remains the primary choice of dosage form, though challenging, for the pharmaceutical scientists. In the last two decades, Oral Liquid Controlled Release (OLCR) formulation has gained a lot of attention because of its advantages over the conventional dosage forms. Method: The world of nanotechnology has paved multiple ways to administer the drug Read More
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Pharmaceutical Cocrystals as an Opportunity to Modify Drug Properties: From the Idea to Application: A Review
Authors: Agnieszka Sokal and Edyta PindelskaThe properties of many drugs which have been available on the pharmaceutical market for a long time still need to be improved. Cocrystals are the solid state drug modification which can improve properties such as low solubility, stability and mechanical properties (e.g. compressibility). In this paper, examples of how to use cocrystals to modify properties of API (Active Pharmaceutical Ingredient) will be reported. Additionally, in Read More
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Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach
Authors: Mark McCully, Macarena Sanchez-Navarro, Meritxell Teixido and Ernest GiraltThe brain is a complex, regulated organ with a highly controlled access mechanism: The Blood-Brain Barrier (BBB). The selectivity of this barrier is a double-edged sword, being both its greatest strength and weakness. This weakness is evident when trying to target therapeutics against diseases within the brain. Diseases such as metastatic brain cancer have extremely poor prognosis due to the poor permeability of many therape Read More
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Applications of Polymeric Nanoparticles in Oral Diseases: A Review of Recent Findings
Authors: Paula Chaves, Joao Oliveira, Alex Haas and Ruy C. R. BeckPolymeric nanoparticles are promising drug delivery systems due to their physicochemical properties, which may be explored to improve the treatment and prevention of several diseases, including oral conditions. Moreover, the pharmacological effects of polymers may be improved by nanostructuration. Therefore, this article provides a detailed review of the studies published between 2010 and 2017 covering the use of Read More
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Synthesis of Novel Derivatives of Quinazoline Schiff base Compound Promotes Epithelial Wound Healing
Quinazoline is an aromatic bicyclic compound exhibiting several pharmaceutical and biological activities. This study was conducted to investigate the potential wound healing properties of Synthetic Quinazoline Compound (SQC) on experimental rats. The toxicity of SQC was determined by MTT cell proliferation assay. The healing effect of SQC was assessed by in vitro wound healing scratch assay on the skin fibroblast cells (BJ-5t Read More
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Cyclodextrins as Drug Carriers in Pharmaceutical Technology: The State of the Art
Authors: Jaime Conceicao, Oluwatomide Adeoye, Helena M. Cabral-Marques and Jose M. S. LoboBackground: Cyclodextrins (CDs) are versatile excipients with an essential role in drug delivery, as they can form non-covalently bonded inclusion complexes (host-guest complexes) with several drugs either in solution or in the solid state. Methods: The main purpose of this publication was to carry out a state of the art of CDs as complexing agents in drug carrier systems. In this way, the history, properties and pharmaceutical Read More
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Systematic Development and Optimization of an in-situ Gelling System for Moxifloxacin Ocular Nanosuspension using High-pressure Homogenization with an Improved Encapsulation Efficiency
Authors: Lalit K. Khurana, Romi Singh, Harinder Singh and Manju SharmaBackground: The objective of this study was to apply Quality by Design (QbD) principles on process parameter optimization for the development of hybrid delivery system (combination of (SLNs) and In-situ gelling system) for hydrophilic drug Moxifloxacin Hydrochloride (MOX) to achieve its controlled delivery, which otherwise may not be possible through single type of technology. Methods: Risk assessment studies were carri Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
- Issue 46
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- Issue 1
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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