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- Volume 24, Issue 14, 2018
Current Pharmaceutical Design - Volume 24, Issue 14, 2018
Volume 24, Issue 14, 2018
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Signaling Pathways in Inflammation and Anti-inflammatory Therapies
Authors: Yiu T. Yeung, Faisal Aziz, Angelica Guerrero-Castilla and Sandro ArguellesDuring the past decade, an abundance of new evidence highlighted the importance of inflammation in the development of chronic pathologies such as neurodegeneration, cancer, diabetes, cardiovascular disease and inflammatory bowel disease. However, most of the current therapies do not address the underlying problem and better therapies are urgently needed. A growing number of researchers have discovered various si Read More
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The Role of Inflammation in Neurological Disorders
Authors: Diana Degan, Raffaele Ornello, Cindy Tiseo, Antonio Carolei, Simona Sacco and Francesca PistoiaTraditionally neurological diseases have been classified, on the basis of their pathogenesis, into vascular, degenerative, inflammatory and traumatic diseases. Examples of the main inflammatory neurological diseases include multiple sclerosis, which is characterized by an immune-mediated response against myelin proteins, and meningoencephalitis, where the inflammatory response is triggered by infectious agents. Howeve Read More
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Cytochrome P450S and Alcoholic Liver Disease
Authors: Yongke Lu and Arthur I. CederbaumAlcohol consumption causes liver diseases, designated as Alcoholic Liver Disease (ALD). Because alcohol is detoxified by alcohol dehydrogenase (ADH), a major ethanol metabolism system, the development of ALD was initially believed to be due to malnutrition caused by alcohol metabolism in liver. The discovery of the microsomal ethanol oxidizing system (MEOS) changed this dogma. Cytochrome P450 enzymes (CYP) constit Read More
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Advances in the Use of Anti-inflammatory Agents to Manage Chemotherapy-induced Oral and Gastrointestinal Mucositis
Authors: Vaishnavi J. Mahendran, Andrea M. Stringer, Susan J. Semple, Yunmei Song and Sanjay GargMucositis is a side effect associated with the use of chemotherapy, and has a significant impact on the quality of life. Mucositis, by definition, refers to the inflammation of the mucosa and occurs throughout the alimentary tract from the mouth to anus. Nuclear Factor kappa B (NFΚB) encompasses a family of transcription factors, which upregulate pro-inflammatory cytokines. These are recognized as key targets in dev Read More
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Molecular Targets of Phytochemicals for Skin Inflammation
Authors: Jong-Eun Kim and Ki W. LeeSkin is a protective organ and the largest of the human body. Due to its pivotal role in aesthetic appearance, skin health has a significant impact on quality of life. Chronic inflammation of the skin often marks the beginning of various skin diseases. Immune-mediated responses serve to protect the body from external insults and require succinct control, and can lead to ongoing cellular damage and various skin conditions if left u Read More
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Recent Findings in Molecular Basis of Inflammation and Anti-inflammatory Plants
Authors: Sedigheh Kazemi, Hedayatollah Shirzad and Mahmoud Rafieian-KopaeiInflammation is one of the most important body responses provided by the immune system since it ensures survival when tissues are affected by injuries or infections. The inflammatory response is an important process for maintenance of normal tissue homeostasis. In contrast to acute inflammation, chronic inflammation does not have a useful impact. Prevention and suppression of inflammation are necessary to reduc Read More
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Role of Melatonin in the Inflammatory Process and its Therapeutic Potential
Authors: Livia Carrascal, Pedro Nunez-Abades, Antonio Ayala and Mercedes CanoMelatonin is an indolamine synthesized and secreted by the pineal gland along with other extrapineal sources including immune system cells, the brain, skin and the gastrointestinal tract. Growing interest in this compound as a potential therapeutic agent in several diseases stems from its pleiotropic effects. Thus, melatonin plays a key role in various physiological activities that include regulation of circadian rhythms, immu Read More
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Potential Use of Nanomedicine for the Anti-inflammatory Treatment of Neurodegenerative Diseases
Neurodegenerative diseases, like Alzheimer´s and Parkinson´s disease, are a group of disorders that have in common their increasingly high prevalence along with the shortage of effective treatments. In addition, the scientific community faces the challenge of getting the drugs used in these treatments to cross the blood-brain barrier (BBB) and reach the brain in sufficient concentration to be able to exert its effect. Hen Read More
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Virtual Screening Studies for Discovery of Novel Inhibitors of Inflammatory Process Targets
Inflammation has been very evident in infectious diseases, but in recent times research has increasingly shown that a range of non-infectious diseases may present with inflammatory conditions. This fact becomes important as new anti-inflammatory drugs emerge with different targets for treatment of diseases. Virtual screening (VS) involves applying computational methods to discover new ligands for biological structures f Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
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- Issue 24
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- Issue 18
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- Issue 14
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- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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