- Home
- A-Z Publications
- Current Pharmaceutical Design
- Previous Issues
- Volume 24, Issue 21, 2018
Current Pharmaceutical Design - Volume 24, Issue 21, 2018
Volume 24, Issue 21, 2018
-
-
Process Intensification Techniques for the Production of Nano- and Submicronic Particles for Food and Medical Applications
Authors: Marco Stoller, Luca Di Palma, Srikanth Vuppala, Nicola Verdone and Giorgio VilardiBackground: Nowadays, nanoparticles are of great interest for the industry due to their numerous possible applications in several fields. Research on this topic seeks to develop many procedures to produce nanoparticles, mostly at lab scale, batch-wise and with low yield. These procedures generally do not suit industrial needs of continuous, high capacity production. Moreover, the product characteristics require targeting na Read More
-
-
-
Cocrystal and its Application in the Field of Active Pharmaceutical Ingredients and Food Ingredients
Authors: Na Wang, Chuang Xie, Haijiao Lu, Nannan Guo, Yajing Lou, Weiyi Su and Hongxun HaoBackground: The development of solid drug dosage form and food ingredients is constrained by their low solubility, low dissolution, low bioavailability and poor physicochemical properties. Formation of cocrystal is a novel and promising method to enhance and improve the properties of materials without breaking the covalent bonds. Methods: The goal of this review is to summarize the cocrystals and their applications Read More
-
-
-
Soft Biomaterial-based Nanocrystal in Pharmaceutical
Authors: Nandi Chen, Taojunfeng Su, Zhe Cheng and Feifei AnBackground and Objective: Bio-soft material, a class of derivatives of the natural or synthetic material, is getting more and more prevalent in biomedical researches and applications due to the advantages such as in-vivo biodegradation, good water solubility and designable targeting ability. With the presence of bio-soft materials, the drug nanocrystal can be easily generated and aggregated in a feasible process. Given the p Read More
-
-
-
Pharmaceutical Strategies for Stabilizing Drug Nanocrystals
Authors: Hyerim Yang, Hyeongmin Kim, Sumin Jung, Hyeyeon Seo, Shofa K. Nida, Seung-Yup Yoo and Jaehwi LeeBackground: Nanocrystallization technologies have been widely studied in recent years, as the formulation of drug nanocrystals solves problems of poor drug solubility and bioavailability. However, drug nanocrystals in the size range of 1–1000 nm usually need to be accompanied by stabilizers, such as polymers or surfactants, to enhance their stability. Despite their simplicity, improved dissolution rate, and enhanced bioavailabili Read More
-
-
-
The Effects of Polymorphism on Physicochemical Properties and Pharmacodynamics of Solid Drugs
Authors: Yanan Zhou, Jingkang Wang, Yan Xiao, Ting Wang and Xin HuangBackground: Nowadays, the polymorphism of solid materials plays important roles in pharmaceutical field, food industry, fine chemicals and so on. Due to the differences in crystal structure, different polymorphs of a given solid drug show different physicochemical characteristics, which may lead to different drug bioavailability and half-life of the drug. Studies about polymorphism of solid drugs have become an indispensable i Read More
-
-
-
Kinetics of the Solution-Mediated Polymorphic Transformation of Organic Compounds
By Lek WanthaPolymorphism is a behavior of a substance to crystallize into more than one district crystal structures. Preferential formation of a polymorph depends strongly on the kinetics of the relevant mechanisms. Solutionmediated polymorphic transformation is an important mechanism in crystallization of organic compounds from solution. Knowing its kinetics allows us to understand the process and control the polymorphic Read More
-
-
-
Recent Trends in Nanocrystals for Pharmaceutical Applications
Authors: Leming Sun, Yanzi Hu and Lianbing ZhangBackground: As the quick development of modern methods and technologies currently, more and more drugs have been invented with a better efficiency. However, the poor water solubility has limited the drugs' pharmaceutical application. Methods: Tremendous research has been put in the design and development of nanocrystals for pharmaceutical applications over the past few decades. The nanocrystals not only have the Read More
-
-
-
Recent Advances in Nanosuspension Technology for Drug Delivery
Authors: Daisy Arora, Bharat Khurana, Goutam Rath, Sanju Nanda and Amit K. GoyalBackground: Discovery and development of BCS class 1 drugs through high throughput screening is one of the biggest challenge faced by formulation scientist. Methods: There are a number of approaches that have been exploited to enhance the solubility and permeability of drugs. Among them, development of nanosuspension has offered several benefits. These techniques may increase effective surface area due t Read More
-
-
-
Nanocrystal Technology as a Strategy to Improve Drug Bioavailability and Antitumor Efficacy for the Cancer Treatment
Authors: Mingxue Fan, Sicong Geng, Yang Liu, Jing Wang, Yiting Wang, Jian Zhong, Zhiqiang Yan and Lei YuBackground and Objective: Nanocrystal technology is an effective approach which can increase the dissolution rate of poorly water-soluble drugs by raising their saturation solubility, thus improving the drug bioavailability. With the development of nanocrystals, its preparation approaches have gradually matured, which can be generally divided into Bottom-up, Top-down and Combinative technologies. Methods: A systematic liter Read More
-
-
-
Nanocrystals: The Preparation, Precise Control and Application Toward the Pharmaceutics and Food Industry
Authors: Cao Wu, Zhou Chen, Ya Hu, Zhiyuan Rao, Wangping Wu and Zhaogang YangCrystallization is a significant process employed to produce a wide variety of materials in pharmaceutical and food area. The control of crystal dimension, crystallinity, and shape is very important because they will affect the subsequent filtration, drying and grinding performance as well as the physical and chemical properties of the material. This review summarizes the special features of crystallization technology and the p Read More
-
-
-
Recent Advances in Magnetic Nanoparticle-based Molecular Probes for Hepatocellular Carcinoma Diagnosis and Therapy
Authors: Qi Zhang, Sudan Wang, Ruirui Qiao, Michael R. Whittaker, John F. Quinn, Thomas P. Davis and Hongjun LiHepatocellular carcinoma (HCC) is one of the most common cancers worldwide, leading to the second most likely cause of cancer-related deaths. Medical imaging is crucial in clinic for HCC screening and diagnosis. Due to the relatively high special resolution and excellent sensitivity, magnetic resonance imaging (MRI) by using magnetic nanoparticle-based contrast agents has been used so far in HCC imaging and staging, demo Read More
-
-
-
Crystal Engineering: Upcoming Paradigm for Efficacious Pulmonary Drug Delivery
Authors: Preshita P. Desai, Sanyat S. Mapara and Vandana B. PatravaleBackground and objective: Pulmonary drug delivery has transformed over a past few decades from being a platform for local pulmonary disease treatment to systemic drug delivery opportunities. In case of pulmonary delivery systems, particle properties are critical as they affect inhalation efficacy, pulmonary deposition, drug delivery and overall performance. With this in view, particle engineering has emerged as an advan Read More
-
-
-
Process Analytical Technology for Crystallization of Active Pharmaceutical Ingredients
Authors: Chandrakant R. Malwade and Haiyan QuBackground: Pharmaceutical industry is witnessing increased pressure to introduce innovative and efficient processes for manufacturing Active Pharmaceutical Ingredients (APIs) in order to be competitive as well as to meet the stringent product quality requirements set by regulatory authorities. Crystallization with its ability to engineer the final product to the desired qualities such as purity, polymorphic form, particle s Read More
-
-
-
Crystal Engineering for Enhanced Solubility and Bioavailability of Poorly Soluble Drugs
Authors: Jaleh Varshosaz, Erfaneh Ghassami and Saeedeh AhmadipourBackground: Crystal engineering is dealing with the creation of new structures and new properties in drug molecules through inter-molecular interactions. Researchers of pharmaceutical sciences have used this knowledge to alter the structure of crystalline medications in order to remedy the problems of more than 40% of the new designed drugs which suffer from low solubility and consequently, low bioavailability which h Read More
-
-
-
Nanocrystals Technology for Pharmaceutical Science
Authors: Zhongyao Cheng, Yumei Lian, Zul Kamal, Xin Ma, Jianjun Chen, Xinbo Zhou, Jing Su and Mingfeng QiuBackground: Nanocrystals technology is a promising method for improving the dissolution rate and enhancing the bioavailability of poorly soluble drugs. In recent years, it has been developing rapidly and applied to drug research and engineering. Nanocrystal drugs can be formulated into various dosage forms. Objective: This review mainly focused on the nanocrystals technology and its application in pharmaceutical scienc Read More
-
-
-
Phase Behavior of Polymorphic Fats in Drug Delivery Systems - A Review of the State of Art
Fats are essential nutrients that have a significant role in the human diet and are essential to provide energy. Fatty acids are present in several types of lipids, such as triglycerides and phospholipids. Fatty acids differ among them, depending on the number of double bonds and on the length of the hydrocarbon chains. If there are no double bonds, the fatty acids are considered saturated and show a linear structure. Compoun Read More
-
Volumes & issues
-
Volume 31 (2025)
-
Volume 30 (2024)
-
Volume 29 (2023)
-
Volume 28 (2022)
-
Volume 27 (2021)
-
Volume 26 (2020)
-
Volume 25 (2019)
-
Volume 24 (2018)
- Issue 46
- Issue 45
- Issue 44
- Issue 43
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
-
Volume 23 (2017)
-
Volume 22 (2016)
-
Volume 21 (2015)
-
Volume 20 (2014)
-
Volume 19 (2013)
-
Volume 18 (2012)
-
Volume 17 (2011)
-
Volume 16 (2010)
-
Volume 15 (2009)
-
Volume 14 (2008)
-
Volume 13 (2007)
-
Volume 12 (2006)
-
Volume 11 (2005)
-
Volume 10 (2004)
-
Volume 9 (2003)
-
Volume 8 (2002)
-
Volume 7 (2001)
-
Volume 6 (2000)
Most Read This Month
Article
content/journals/cpd
Journal
10
5
false
en
