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- Volume 18, Issue 9, 2012
Current Pharmaceutical Design - Volume 18, Issue 9, 2012
Volume 18, Issue 9, 2012
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Strategies of Engineering Nanoparticles for Treating Neurodegenerative Disorders
Background: Neurodegenerative disorders (NDs) are typically referred to Alzheimer's disease, Parkinson's diseases, amyotrophic lateral sclerosis and prion disease. These are commonly debilitating and, unfortunately, have few therapeutic options. Objective: In this review, we describe some emerging advances in nanoengineering strategies for the treatment of NDs. One of the main difficulties in fighting against NDs is to over Read More
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Viral Infection and Obesity: Current Status and Future Prospective
Background: The association of pathogenic viruses with obesity has now been well-known in both human and animals. Globally, human obesity has become a serious problem leading to the emergence of multiple lifethreatening diseases. Adenoviruses contribute a significant role in the induction of obesity by affecting various pathways. Due to impaired immunity, obese individuals are more prone to nosocomial infections leading t Read More
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Exploration of Various Proteins for the Treatment of Alzheimer's Disease
Authors: Badar ul Islam, Syed Kashif Zaidi, Mohammad Amjad Kamal and Shams TabrezBackground: Alzheimer's disease (AD) is an irreversible multifaceted neurodegenerative disorder that gradually degrades neuronal cells. It is the most frequent cause of memory loss and dementia in elderly individuals worldwide. The extracellular deposition of beta amyloid (Aβ), intracellular neurofibrillary tangles (NFTs) retention, neuronal decline and neurotransmitter system derangement are the patho-physiological marker Read More
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Methods of Screening-Purification and Antimicrobial Potentialities of Bacteriocin in Health Care
Background: Bacteriocin have been tested as safe and effective alternative molecules over the currently used chemotherapeutic agents. Thus, being an important clinical significance, its screening and recovery methods along with its application are poorly described. Therefore, their screening, purification strategies and utilities must me extended. Thus, in this review, we, summarize potential application, various scree Read More
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Recent Development and Future Prospects of Plant-Based Vaccines
Authors: Sayed Sartaj Sohrab, Mohd. Suhail, Mohammad A. Kamal, Azamal Husen and Esam I. AzharBackground: Growing world population and continuous disease emergence have invited the development of more efficient new vaccines against a range of diseases. Conventional vaccines are being wildly used in the world but their production requires higher cost, more time and better infrastructure. Thus, the idea of plant-based edible vaccine technology has emerged and showed promising results with strong and effec Read More
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Repurposed Drugs as Potential Therapeutic Candidates for the Management of Alzheimer's Disease
Authors: Muhammad Shoaib, Mohammad Amjad Kamal and Syed Mohd Danish RizviBackground: Drug repurposing is an innovative approach as it provides new indications for already approved and established drugs. Due to high failure rates and cost involved in traditional drug development procedures, many pharmaceutical companies are primarily focusing on drug repurposing strategy. In Alzheimer disease (AD), existing therapeutic agents only provide symptomatic benefits and does not play a role Read More
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Pharmacological and Toxicological Profile of Harmane-β-Carboline Alkaloid: Friend or Foe
Authors: Haroon Khan, Seema Patel and Mohammad A. KamalBackground: The plant secondary metabolites have an outstanding therapeutic potential and success over the years. In fact, it is the foundation of numerous clinically used drugs. Similarly, these is a general perception that these products are inherent safety. However, such products might have toxic/unwanted lethal effects therefore, along with biological relevance, toxicological evaluation is equally important for clinical applicati Read More
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Role of Nutrients and Phyto-compounds in the Modulation of Antimicrobial Resistance
Background: Antimicrobial resistance is quickly spreading and has become a major public health problem worldwide. If this issue is not resolved, it may cause a shift back to the pre-antibiotics era and infectious disease will again be a serious problem, especially in developing countries. Since the discovery of antibiotics, bacterial resistance has emerged, enabling certain bacteria to withstand antibiotic action. The emergence of an Read More
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Translational Shift of HSP90 as a Novel Therapeutic Target from Cancer to Neurodegenerative Disorders: An Emerging Trend in the Cure of Alzheimer's and Parkinson's Diseases
Background: Despite having extensive research, the apparent pathogenic mechanism of Alzheimer's disease (AD), Parkinson's disease (PD) and other neurodegenerative diseases (NDs) have not yet fully understood. The Heat Shock Protein 90 (HSP90), a ubiquitous molecular chaperone, found to have an important role in averting protein misfolding and aggregation through inhibition of apoptotic activity in neuro-inflamma Read More
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Editorial [Hot Topic: In Silico Lead Identification and Optimization for Drug Discovery (Executive Guest Editor: Shuxing Zhang)]
More LessDrug discovery and development is a time-consuming and resource-demanding process. Even with significant increases of the global R&D expenses, the pharmas' discovery engines have stalled. Therefore, any technologies that can improve the efficiency of the pipeline would be highly appreciated. Current state-of-the-art in silico techniques provide cost-effective and time-efficient approaches for lead discovery and opti Read More
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Editorial [Hot Topic: In Silico Lead Identification and Optimization for Drug Discovery (Executive Guest Editor: Shuxing Zhang)]
More LessDrug discovery and development is a time-consuming and resource-demanding process. Even with significant increases of the global R&D expenses, the pharmas' discovery engines have stalled. Therefore, any technologies that can improve the efficiency of the pipeline would be highly appreciated. Current state-of-the-art in silico techniques provide cost-effective and time-efficient approaches for lead discovery and opti Read More
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Computational Insights for the Discovery of Non-ATP Competitive Inhibitors of MAP Kinases
Authors: Michael J. Schnieders, Tamer S. Kaoud, Chunli Yan, Kevin N. Dalby and Pengyu RenDue to their role in cellular signaling mitogen activated protein (MAP) kinases represent targets of pharmaceutical interest. However, the majority of known MAP kinase inhibitors compete with cellular ATP and target an ATP binding pocket that is highly conserved in the 500 plus representatives of the human protein kinase family. Here we review progress toward the development of non-ATP competitive MAP kinase inhibitors for Read More
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Computational Insights for the Discovery of Non-ATP Competitive Inhibitors of MAP Kinases
Authors: Michael J. Schnieders, Tamer S. Kaoud, Chunli Yan, Kevin N. Dalby and Pengyu RenDue to their role in cellular signaling mitogen activated protein (MAP) kinases represent targets of pharmaceutical interest. However, the majority of known MAP kinase inhibitors compete with cellular ATP and target an ATP binding pocket that is highly conserved in the 500 plus representatives of the human protein kinase family. Here we review progress toward the development of non-ATP competitive MAP kinase inhibitors for Read More
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Cis-enone Resorcylic Acid Lactones (RALs) as Irreversible Protein Kinase Inhibitors
Authors: Linyi Wei, Jiuhong Wu, Guanqun Li and Ning ShiResorcylic acid lactones (RALs) constitute a group of polyketide natural products with a large macrocyclic ring fused to resorcylic acid. Despite distinct core scaffold from all marketed kinase inhibitors, RALs bearing a cis-enone moiety have recently shown irreversible yet selective inhibition on a subset of kinases along the MAPK signaling pathway such as MEK, ERK and TAK1. The biochemical and structural studies have dem Read More
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Cis-enone Resorcylic Acid Lactones (RALs) as Irreversible Protein Kinase Inhibitors
Authors: Linyi Wei, Jiuhong Wu, Guanqun Li and Ning ShiResorcylic acid lactones (RALs) constitute a group of polyketide natural products with a large macrocyclic ring fused to resorcylic acid. Despite distinct core scaffold from all marketed kinase inhibitors, RALs bearing a cis-enone moiety have recently shown irreversible yet selective inhibition on a subset of kinases along the MAPK signaling pathway such as MEK, ERK and TAK1. The biochemical and structural studies have dem Read More
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Identification of HIV Inhibitors Guided by Free Energy Perturbation Calculations
Free energy perturbation (FEP) theory coupled to molecular dynamics (MD) or Monte Carlo (MC) statistical mechanics offers a theoretically precise method for determining the free energy differences of related biological inhibitors. Traditionally requiring extensive computational resources and expertise, it is only recently that its impact is being felt in drug discovery. A review of computer-aided anti-HIV efforts employing FEP calc Read More
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Identification of HIV Inhibitors Guided by Free Energy Perturbation Calculations
Free energy perturbation (FEP) theory coupled to molecular dynamics (MD) or Monte Carlo (MC) statistical mechanics offers a theoretically precise method for determining the free energy differences of related biological inhibitors. Traditionally requiring extensive computational resources and expertise, it is only recently that its impact is being felt in drug discovery. A review of computer-aided anti-HIV efforts employing FEP calc Read More
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From Laptop to Benchtop to Bedside: Structure-based Drug Design on Protein Targets
Authors: Lu Chen, John K. Morrow, Hoang T. Tran, Sharangdhar S. Phatak, Lei Du-Cuny and Shuxing ZhangAs an important aspect of computer-aided drug design, structure-based drug design brought a new horizon to pharmaceutical development. This in silico method permeates all aspects of drug discovery today, including lead identification, lead optimization, ADMET prediction and drug repurposing. Structure-based drug design has resulted in fruitful successes drug discovery targeting proteinligand and protein-protein in Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
- Issue 38
- Issue 37
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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