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- Volume 18, Issue 4, 2012
Current Pharmaceutical Design - Volume 18, Issue 4, 2012
Volume 18, Issue 4, 2012
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Editorial [Prodromal Psychosis: Diagnosis and Treatment (Executive Guest Editor: Paolo Fusar-Poli)]
More LessThe onset of schizophrenia is usually preceded by a prodromal phase characterized by functional decline and subtle symptoms, which include attenuated psychotic phenomena, cognitive impairments and a decline in socio-occupational function. Research into the early phases of psychosis promises to provide important clues to the mechanisms underlying schizophrenia and psychotic disorders. Investigation of subjects at th Read More
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The Vulnerability to Schizophrenia Mainstream Research Paradigms and Phenomenological Directions
Authors: Giovanni Stanghellini and Paolo Fusar-PoliEarly psychopathological attempts to characterize the vulnerability to schizophrenia were based on the phenomenological method. From the beginning, phenomenologically-oriented psychopathologists have searched the basic vulnerability underlying schizophrenic phenomena in two main domains: depersonalization and derealisation/desocialization. Schizophrenic persons undergo a special kind of depersonalisation: the livi Read More
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The Ultra High Risk Approach to Define Psychosis Risk
Authors: Alison R. Yung, Paolo Fusar-Poli and Barnaby NelsonAlthough prodromal symptoms of psychosis have long been recognized, the clinical management of psychotic disorders conventionally begins at the first episode of frank psychosis, and, until recently, the period immediately preceding the first episode received relatively little attention. Over the last fifteen years, there has been increasing academic and clinical interest in people presenting with potentially prodromal symptom Read More
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Basic Symptoms and the Prediction of First-Episode Psychosis
Recent focus on early detection and intervention in psychosis has renewed interest in subtle psychopathology beyond positive and negative symptoms. Such self-experienced sub-clinical disturbances are described in detail by the basic symptom concept. This review will give an introduction into the concept of basic symptoms and describe the development of the current instruments for their assessment, the Sch Read More
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Rationale and First Results of Developing At-Risk (Prodromal) Criteria for Bipolar Disorder
Bipolar affective disorder (BD) is a severe, recurrent and disabling disorder with devastating consequences for individuals, families and society. Although these hazards and costs provide a compelling rationale for development of early detection and early intervention strategies in BD, the development of at-risk criteria for first episode mania is still in an early stage of development. In this paper we review the literature with Read More
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Can We Detect Psychotic-like Experiences in the General Population?
Authors: B. Nelson, P. Fusar-Poli and A. R. YungThe continuum model of psychosis posits that psychotic symptoms are distributed throughout the population, with diagnosable clinical disorder existing at a certain point along this continuum. The total continuum is made up mainly of non-clinical cases with clinical cases of psychosis representing only a small proportion of the total extended psychosis phenotype. This paper is a narrative review of studies of psychotic Read More
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Reliability and Validity of the Comprehensive Assessment of the at Risk Mental State, Italian Version (CAARMS-I)
Authors: P. Fusar-Poli, R. Hobson, M. Raduelli and U. BalottinThe Comprehensive Assessment of the At Risk Mental State (CAARMS) is a semi-structured interview designed to assess attenuated psychotic symptoms in people at ultra high risk of developing psychosis (UHR). It is widely used worldwide but no studies have ever assessed its psychometric properties in the Italian population. Here we tested the reliability and validity of the Italian version of the CAARMS (CAARMS-I). Psychome Read More
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Abnormal Bodily Experiences May be a Marker of Early Schizophrenia?
Authors: Giovanni Stanghellini, Massimo Ballerini, Paolo Fusar Poli and John CuttingThe purpose of this study is to answer the following question: What are the typical features of abnormal bodily experiences (ABEs) in persons affected by acute first-episode schizophrenia? Our overall objective is to contribute to enhance early diagnosis of schizophrenia, and providing supplementary diagnostic criteria especially for ultra-high risk patients. In a group of 39 patients with firstepisode schizophrenia selected Read More
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Neurocognition in the Psychosis Risk Syndrome: A Quantitative and Qualitative Review
Cognitive dysfunction is a hallmark feature of schizophrenia and is evident across all phases of the illness. While prior metaanalyses have elucidated the level and pattern of cognitive deficits in the premorbid and post-onset periods of psychosis, no metaanalyses of studies of the putative prodromal period have been published. Our primary aim is to provide a meta-analysis of neurocognitive findings from 14 studie Read More
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Neuroimaging and Resilience Factors - Staging of the At-risk Mental State?
Authors: Renata Smieskova, Paolo Fusar-Poli, Anita Riecher-Rossler and Stefan BorgwardtOver the past decade, vulnerability- and psychosis-associated structural and functional brain abnormalities in a population at high clinical risk to develop psychosis were intensively studied. We reviewed the results from studies comparing at-risk mental state (ARMS) individuals with and without subsequent transition to psychosis. Additionally, we introduced a new concept of splitting ARMS population according to the dura Read More
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The Relationship of Developmental Changes in White Matter to the Onset of Psychosis
Authors: Katherine H. Karlsgodt, Sarah C. Jacobson, Marc Seal and Paolo Fusar-PoliSchizophrenia is a disorder with a pronounced developmental component. Accordingly, there is a growing interest in characterizing developmental changes in the period leading up to disease onset, in an effort to develop effective preventative interventions. One of the ongoing neurodevelopmental changes known to occur in the late adolescent period that often overlaps with the prodromal phase and time of on Read More
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Relationship Between Gyrification and Functional Connectivity of the Prefrontal Cortex in Subjects at High Genetic Risk of Schizophrenia
Measures of cortical folding (‘gyrification’) and connectivity are both reported to be disrupted in schizophrenia. There are also reports that increases in prefrontal gyrification may be predictive of subsequent illness in individuals at familial risk of the disorder. Such measures therefore have important potential clinical relevance. The nature of the relationship between cortical morphology and underlying connectivity is h Read More
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Episodic Memory Dysfunction in Individuals at High-Risk of Psychosis: A Systematic Review of Neuropsychological and Neurofunctional Studies
Authors: Isabel Valli, Stefania Tognin, Paolo Fusar-Poli and Andrea MechelliCognitive impairment is one of the key features of schizophrenia, with the largest effect sizes identified for verbal learning and memory, however little is known about its features in the time that precedes psychosis onset. Here we review a total of thirty-two studies that examined memory and learning in populations at clinical and genetic high-risk for psychosis. These studies can be divided into three different categories based Read More
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From the Prodrome to Chronic Schizophrenia: The Neurobiology Underlying Psychotic Symptoms and Cognitive Impairments
Authors: O. D. Howes, P. Fusar-Poli, M. Bloomfield, S. Selvaraj and P. McGuireSchizophrenia is a chronic psychotic disorder that remains a considerable cause of global disease burden. Cognitive impairments are common and contribute significantly to the morbidity of the disorder. Over the last two decades or so molecular imaging studies have refined understanding of the pathophysiology underlying the development of psychosis and cognitive impairments. Firstly they have consistently implicated presy Read More
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Glutamate and Psychosis Risk
Authors: Alice Egerton, Paolo Fusar-Poli and James M. StoneIncreasing evidence suggests that abnormalities in glutamatergic transmission may be associated with psychosis risk. Genetic polymorphisms associated with schizophrenia converge on NMDA receptor signalling pathways, and transgenic animal models and human neuroimaging studies have shown the functional impact of these risk alleles. Animal models have also shown that environmental risk factors, such as stress, c Read More
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Neurophysiological Alterations in the Prepsychotic Phases
Authors: Nicolas A. Crossley, Miguel Constante, Paolo Fusar-Poli and Elvira BramonElectroencephalography and Magnetoencephalography have provided valuable information about the brain functioning in psychosis. In the last few years, authors have demonstrated that there are neurophysiological alterations already in the prodromal period, before the development of psychosis. This makes them promising tools for predicting a future transition to psychosis. In this paper we review the latest studies usin Read More
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Brain Structural Abnormalities at the Onset of Schizophrenia and Bipolar Disorder: A Meta-analysis of Controlled Magnetic Resonance Imaging Studies
Authors: Luca De Peri, Alessandra Crescini, Giacomo Deste, Paolo Fusar-Poli, Emilio Sacchetti and Antonio VitaA number of structural brain imaging studies and meta-analytic reviews have shown that multiple subtle brain abnormalities are consistently found in schizophrenia and bipolar disorder. Several studies suggest that schizophrenia and affective psychoses share a largely common pattern of brain abnormalities. Aim of the present study was to compare, by means of a meta-analytic approach, brain structural abnormalities, as dete Read More
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Cingulate Volume Abnormalities in Emerging Psychosis
Background Neuroanatomical abnormalities, including cingulate cortex volume abnormalities, are a common feature in psychosis. However, the extent to which these are related to a vulnerability to psychosis, as opposed to the disorder per se, is less certain. Aim und Hypotheses The aim of the present study is to compare cingulate gray matter volumes in different stages of psychosis. We reviewed previous studies of subject Read More
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Biochemical Markers of Impending Psychosis
Authors: Enzo Emanuele, Valentina Martinelli, Vera Abbiati, Paolo Fusar-Poli and Pierluigi PolitiRecent years have witnessed numerous attempts at identifying the biological correlates of impending psychosis. Biochemical markers may theoretically provide a powerful approach to identify at-risk individuals, potentially leading to more effective intervention strategies to treat them. Hopefully, future developments in the field of research biochemistry in patients with at risk mental states or prodromal symptoms will m Read More
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Genetic Vulnerability to Psychosis and Cortical Function: Epistatic Effects between DAAO and G72
Recent studies have described G72 and DAAO as susceptibility genes for schizophrenia and bipolar disorder. Both genes modulate glutamate neurotransmission, which plays a key role in neurocognitive function and is thought to be altered in these disorders. Moreover, in vitro transcription studies indicate that the two genes interact with each other at the molecular level. However, it is unclear how these genes affect cortical Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
- Issue 38
- Issue 37
- Issue 36
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- Issue 3
- Issue 2
- Issue 1
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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