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- Volume 18, Issue 6, 2012
Current Pharmaceutical Design - Volume 18, Issue 6, 2012
Volume 18, Issue 6, 2012
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Editorial [ Hot Topic: Peptides in Diagnosis and Therapy (Executive Guest Editor: Darja Kanduc)]
By Darja KanducDuring the last decade, scientific and clinical research witnessed a progressive shift from genomics to proteomics. Actually, the genomic era promised much [1] and much has left unfulfilled [2], thus also explaining the rapid development of proteomics and its application to drug discovery at the beginning of this century [3]. Proteomics is giving a significance to genes by providing a direct link to their biological activity. Curre Read More
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Mining PeptideAtlas for Biomarkers and Therapeutics in Human Disease
Authors: Sarah Killcoyne, Eric W. Deutsch and John BoyleMass spectrometry information has long offered the potential of discovering biomarkers that would enable clinicians to diagnose disease, and treat it with targeted therapies. PeptideAtlas currently provides access to large-scale spectra data and identification information. This data, and the generation of targeted peptide information, represents the first step in the process of locating disease biomarkers. Reaching the goal of Read More
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Peptides for Therapy and Diagnosis of Alzheimer's Disease
Authors: Susanne Aileen Funke and Dieter WillboldAlzheimer's disease (AD) is a progressive neurodegenerative disorder with devastating effects. The greatest risk factor to develop AD is age. Today, only symptomatic therapies are available. Additionally, AD can be diagnosed with certainty only post mortem, whereas the diagnosis “probable AD” can be established earliest when severe clinical symptoms appear. Specific neuropathological changes like neurofibrillary tangles and a Read More
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Ghrelin and the Brain-gut Axis as a Pharmacological Target for Appetite Control
Authors: Inge Seim, Magdy El-Salhy, Trygve Hausken, Doris Gundersen and Lisa ChopinAppetite regulation is highly complex and involves a large number of orexigenic and anorexigenic peptide hormones. These are small, processed, secreted peptides derived from larger prepropeptide precursors. These peptides are important targets for the development of therapeutics for obesity, a global health epidemic. As a case study, we consider the ghrelin axis. The ghrelin axis is likely to be a particularly useful drug t Read More
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Short Peptide Modules for Enhancing Intestinal Barrier Function
More LessThe intestinal epithelial barrier is indispensable to our immune system. Defects in this barrier function have been observed in intestinal disorders such as inflammatory bowel diseases, food allergies, and celiac diseases. Therefore, the modulation of the barrier function is currently viewed as a potentially positive pharmacological outcome. This review describes a unique peptide, Asn-Pro-Trp- Asp-Gln (NPWDQ), which can finely a Read More
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Peptides in Oral Diseases
Authors: Alberta Lucchese, Agostino Guida, Massimo Petruzzi, Giovanni Capone, Luigi Laino and Rosario SerpicoThe oral cavity is home to numerous viruses and micro-organisms recognized as having a role in various oral diseases as well as in infections in other parts of the body. Indeed, in general a microbial infection underlies or is believed to underlie the ample spectrum of oral diseases, from tooth enamel decay to periodontal lesions, from candidiasis to virus-induced oral squamous cell carcinomas, and bullous autoimmune oral dis Read More
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Apelin in the Control of Body Fluid Homeostasis and Cardiovascular Functions
Authors: Cecile Galanth, Annette Hus-Citharel, Bo Li and Catherine Llorens-CortesThe discovery of apelin, an endogenous ligand of the orphan APJ receptor is an important advance for fundamental research and clinical medicine. Apelin and its receptor have a wide tissue distribution not only in the brain but also in peripheral organs including kidney, heart, vessels, and adipose tissue. Apelin is implicated in many physiological and pathophysiological processes such as the regulation of body fluid homeost Read More
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Thymosin β4 Protein Therapy for Cardiac Repair
Authors: Karina N. Dube, Sveva Bollini, Nicola Smart and Paul R. RileyClinical interventions leading to improved survival in patients with acute myocardial infarction have, paradoxically, increased the need for cardiac regenerative strategies as more people are living with heart failure. Over the last 10-15 years there have been significant advances in our understanding of cell-based therapy for cardiac repair. Evidence that paracrine stimulation largely underlies the functional benefits in ce Read More
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Therapeutic Potential of Host Defense Peptides in Antibiotic-resistant Infections
Authors: Nicole J. Afacan, Amy T.Y. Yeung, Olga M. Pena and Robert E.W. HancockThe emergence of infections caused by multi-drug resistant (MDR) pathogens pose a major burden to modern healthcare. Exacerbating this issue is the substantial decline in development of new classes of antibiotics by pharmaceutical companies. This has led to renewed interest in the therapeutic potential of natural anti-infective agents such as host defense peptides (HDPs). The broad antimicrobial and immunomodula Read More
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Peptides in Melanoma Therapy
More LessPeptides derived from tumor associated antigens can be utilized to elicit a therapeutically effective immune response against melanoma in experimental models. However, patient vaccination with peptides - although it is often followed by the induction of melanoma- specific T lymphocytes - is rarely associated with tumor response of clinical relevance. In this review I summarize the principles of peptide design Read More
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Circumscribing the Conformational Peptide Epitope Landscape
Authors: Guglielmo Lucchese, Michele Calabro and Darja KanducThe development of vaccines for new and re-emerging pathologies and infections is based on the ability to define immunogenic epitopes. An immunogenic B-cell peptide epitope is a specific restricted antigen region that is capable of eliciting a humoral immune response and of combining with a specific site on antibodies. Using a number of experimental models and based on data from several literature reports, we identifi Read More
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Pharmacological Modulation of Microparticle Release: New Strategies for the Management of Atherothrombotic Vascular Disorders
Microparticles (MPs) are submicron vesicles (0.1-1 μm) shed from the membrane of platelets, monocytes, endothelial cells and other cell types. Abundant clinical evidence relates increased plasma levels of MPs with several cardiovascular and inflammatory diseases, being a topic of tremendous interest in recent years. MPs have been proposed as potential effectors in thrombosis, inflammation, vascular injury or angi Read More
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Antiplatelet Therapy in Atherothrombotic Cardiovascular Diseases for Primary and Secondary Prevention: A Focus on Old and New Antiplatelet Agents
Authors: Burak Pamukcu, Kurt Huber and Gregory Y.H. LipAspirin has long been the mainstay of primary and secondary prevention against myocardial infarction and ischemic cerebrovascular events. However, the incremental value of aspirin for primary prevention has recently been subject to debate given data from recent large clinical trials, as the net clinical benefit is small. In secondary prevention, aspirin is still strongly recommended. Efforts in obtaining more efficient antiplat Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
- Issue 38
- Issue 37
- Issue 36
- Issue 35
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- Issue 29
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- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
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- Issue 3
- Issue 2
- Issue 1
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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