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- Volume 14, Issue 9, 2008
Current Pharmaceutical Design - Volume 14, Issue 9, 2008
Volume 14, Issue 9, 2008
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Editorial [ Trypanosomiais and Leishmaniasis “Recent Development in the Chemotherapy of Infectious Diseases caused by Parasitic Protozoa” Executive Editor: Wanderley de Souza ]
More LessThe high impact of diseases caused by parasitic protozoa shortens working capacity, causing premature disability, shortening of life quality and expectancy of individuals, leading to economical and social losses. In this issue of Current Pharmaceutical Design several articles, written by colleagues with a major contribution on the area, deal with drugs that interfere with specific structures/organelles of the most important Read More
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An Introduction to the Structural Organization of Parasitic Protozoa
More LessAs eukaryotic cells, protozoa present a classical structural organization where most of the structures and organelles typical of mammalian cells are found. However, even for usual organelles these organisms present structural diversity. In addition, some of the protozoa structures, such as the mitochondria, peroxisomes and even the Golgi complex, are not observed. On the other hand, new organelles such as the hydrogenoso Read More
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Mitochondrion of Protozoan Parasite Emerges as Potent Therapeutic Target:Exciting Drugs are on the Horizon
Authors: Nilkantha Sen and Hemanta K. MajumderChemotherapy is the primary means of treating protozoan parasitic infections. A problem for chemotherapy is to find a novel and potential molecule in protozoa, which could be exploited as drug target. To reach this goal, mitochondrion of protozoa can be considered as the most valuable and potential organelle because of its unique structure and function compared to their natural host habitat. In fact, the respirat Read More
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Kinetoplast as a Potential Chemotherapeutic Target of Trypanosomatids
More LessMany trypanosomatid protozoa, such as those belonging to the Trypanosoma and Leishmania genera cause serious diseases to man. Such parasites present an unusual feature, a mitochondrial DNA arranged in catenated circles, known as kinetoplast DNA (kDNA). The replication of kDNA network is a complex process, which involves many proteins. Some of them are classified as topoisomerases and play essential bi Read More
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The Plastid-Like Organelle of Apicomplexan Parasites as Drug Target
Authors: J. Wiesner, A. Reichenberg, S. Heinrich, M. Schlitzer and H. JomaaApicomplexan parasites infectious to humans include Plasmodium spp., Babesia spp., Toxoplasma gondii, Cryptosporidium spp., Isospora belli and Cyclospora cayetanensis. With exception of Cryptosporidium spp., these parasites possess a non-photosynthetic plastid-like organelle called apicoplast. The apicoplast possesses a small circular genome and harbours prokaryotic-type biochemical pathways. As the most import Read More
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The Hydrogenosome as a Drug Target
More LessHydrogenosomes are spherical or slightly elongated organelles found in non-mitochondrial organisms. In Trichomonas hydrogenosomes measure between 200 to 500 nm, but under drug treatment they can reach 2 μm. Like mitochondria hydrogenosomes: (1) are surrounded by two closely apposed membranes and present a granular matrix: (2) divide in three different ways: segmentation, partition and the heart form; (3) th Read More
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The Acidocalcisome as a Target for Chemotherapeutic Agents in Protozoan Parasites
Authors: Roberto Docampo and Silvia N.J. MorenoAcidocalcisomes are acidic organelles rich in calcium and phosphorus that have been conserved from bacteria to man. In parasitic protozoa acidocalcisomes possess enzymes that are absent or different from their mammalian counterparts and could be potential targets for chemotherapy, such as the vacuolar proton translocating pyrophosphatase, and the soluble inorganic pyrophosphatase, both of which a Read More
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Drugs Targeting Parasite Lysosomes
Lysosomes were first described as vacuolar structures containing various hydrolytic enzymes at acidic pH. Subsequent studies revealed that the lysosome/vacuolar system is complex and composed of distinct membrane-enclosed vesicles including endosomes, primary and mature lysosomes, autophagic vesicles, residual bodies, multivesicular bodies, and digestive lysosomes. Lysosomes express a battery of hydrolytic enzymes Read More
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Fatty Acid Synthesis in Protozoan Parasites: Unusual Pathways and Novel Drug Targets
Authors: C. D. Goodman and G. I. McFaddenFatty acid biosynthesis pathways in protozoan parasites are reviewed with a view to targeting this metabolism for drug therapy. The type II fatty acid biosynthesis pathways derived from bacteria in protozoan relict plastids and mitochondria are examined in different groups with emphasis on apicomplexa. The suitability of different enzymes from the type II fatty acid biosynthesis pathway for drug intervention, and the state-of- Read More
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Targeting the Cell Cycle in the Pursuit of Novel Chemotherapies Against Parasitic Protozoa
More LessProtozoan parasites, such as those responsible for malaria and African Sleeping Sickness, represent a huge burden to the developing world. Current chemotherapy to combat these diseases is inadequate: antiquated, toxic and increasingly ineffective due to drug resistance. In this article, the potential usefulness of targeting key regulators of the parasite cell cycle will be discussed, paying particular attention to three families of Read More
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Ultrastructural Alterations in Organelles of Parasitic Protozoa Induced by Different Classes of Metabolic Inhibitors
Authors: Juliany C. Fernandes Rodrigues and Wanderley de SouzaParasitic protozoa such as Leishmania, Trypanosoma, Plasmodium, Toxoplasma gondii, Giardia and Trichomonas are able to cause several diseases affecting millions of people around the world with dramatic consequences to the socio-economic life of the affected countries. Diseases like malaria, leishmaniasis and trypanosomiasis have been classified by the World Health Organization as neglected diseases, because they Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
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- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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