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- Volume 14, Issue 6, 2008
Current Pharmaceutical Design - Volume 14, Issue 6, 2008
Volume 14, Issue 6, 2008
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Editorial [ Histone Deacetylase Inhibitors Executive Editor: Dimitra Hadjipavlou-Litina ]
More LessHistone deacetylases (HDACs) are a family of enzymes that regulate chromatin remodeling and gene transcription. They consequently control critical cellular processes, including cell growth, cell cycle regulation, DNA repair, differentiation, proliferation, and apoptosis. Histone deacetylases are known to play an important role in the regulation of gene expression by catalyzing the deacetylation of the acetylated e-amino grou Read More
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Chemical Origins of Isoform Selectivity in Histone Deacetylase Inhibitors
Authors: Alan P. Kozikowski and Kyle V. ButlerHistones undergo extensive posttranslational modifications that affect gene expression. Acetylation is a key histone modification that is primarily regulated by two enzymes, one of which is histone deacetylase (HDAC). The activity of HDAC causes transcriptional silencing of DNA. Eleven distinct zinc-dependent histone deacetylase isoforms have been identified in humans. Each isoform has a unique structure and function, and re Read More
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Isoform-Selective Histone Deacetylase Inhibitors
Authors: Takayoshi Suzuki, Yukihiro Itoh and Naoki MiyataHistone deacetylases (HDACs) catalyze the deacetylation of the acetylated lysine residues of histones and non-histone proteins, and are involved in various fundamental life phenomena, such as gene expression and cell cycle progression. Thus far, eighteen HDAC family members have been identified and they can be divided into two categories, i.e., zinc-dependent enzymes (HDAC1-11) and NAD+-dependent enzymes (SIRT1- Read More
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From Natural Products to Small Molecule Ketone Histone Deacetylase Inhibitors: Development of New Class Specific Agents
Authors: Philip Jones and Christian SteinkuhlerHistone deacetylases (HDACs) are one of two counteracting enzyme families whose activity controls the acetylation state of lysine protein residues, notably those contained in the N-terminal extensions of the core histones. Deregulation of the acetylation state of specific lysine residues has been implicated in a multitude of biologic processes, notably cancer, where HDACs are known to be involved in the control of cell cycle progre Read More
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Inhibitors of NAD+ Dependent Histone Deacetylases (Sirtuins)
Authors: Manfred Jung, Robert C. Neugebauer and Wolfgang SipplHistone deacetylases (HDACs) are enzymes that deacetylate acetyl lysines in histones and various non-histone proteins. Three classes of histone deacetylases have been described in humans: class I, II and IV were shown to be zinc dependent amidohydrolases and eleven subtypes are known today (HDAC1-11). Class III enzymes depend in their catalysis on NAD+ with the subsequent formation of nicotinamide and O-acetyl-ADP Read More
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Fibrate-Associated Adverse Effects Beyond Muscle and Liver Toxicity
Authors: M. S. Elisaf, M. Florentin, E. N. Liberopoulos and D. P. MikhailidisFibrate derivatives have a 40-year history in the management of dyslipidemia. Although this class of drugs is generally well tolerated, several safety issues have arisen from their use. In the present article we review the literature describing side effects associated with the use of fibrates except for those that are liver and muscle related. These effects are less well known but are clinically relevant.
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Computational Analysis of the Interaction between Ligand-Receptor Pairs
More LessUnderstanding the interactions between protein receptor-ligand pairs is of great pharmaceutical interest for structure-based drug design. It has become apparent that identifying interesting ligand-receptor pairs by computational techniques can offer new insights into functional studies of uncharacterized proteins. More importantly, the matching protein families of ligands and their receptors make it possible more easily to Read More
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Role of Toll-Like Receptors in Immune Responses to Chlamydial Infections
Authors: Xi Yang and A. G. JoyeeChlamydiae are important human pathogens which are leading causative agents for a variety of disease conditions including ocular, respiratory and sexually transmitted diseases, thus causing significant morbidity worldwide. Many of the human diseases caused by Chlamydia species are considered to be immunopathologically mediated. Toll like receptors (TLRs) have emerged as one of the major components of the immu Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
- Issue 36
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- Issue 31
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- Issue 14
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- Issue 10
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- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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