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- Volume 14, Issue 2, 2008
Current Pharmaceutical Design - Volume 14, Issue 2, 2008
Volume 14, Issue 2, 2008
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Editorial [Hot Topic:Mechanisms of Cell Death: Life Evolution (Executive Editor: M. de Eguileor)]
More LessExtensive studies have been devoted to mechanisms leading to the activation of cell death. Three major types of cell death are distinguished based on different criteria: apoptosis, oncosis and autophagic cell death. All these processes are well conserved in life evolution as highlighted in the reviews here gathered. Samara and Tavernarakis review the current understanding of cell death pathways in Caenorhabditis elegans, fo Read More
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Autophagy and Cell Death in Caenorhabditis elegans
Authors: Nektarios Tavernarakis and Chrysanthi SamaraCell death is a major component of developmental programs. Controlled killing of specific cells at appropriate time points is required for normal growth and shaping of organisms. However, cellular demolition can also result in a variety of pathologies that are frequently fatal, when implemented inappropriately. Delineation of cell death mechanisms has been greatly facilitated by the use of simple model organisms s Read More
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Autophagy in Invertebrates: Insights Into Development, Regeneration and Body Remodeling
Autophagy is a process in which eukaryotic cells sequester and degrade cytoplasm and organelles via the lysosomal pathway. This process allows turnover of intracellular organelles, participates in the maintenance of cellular homeostasis and prevents accumulation of defective cellular structures. Increased autophagy is normally induced by environmental cues such as starvation and hormones, while excessive levels of Read More
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Cell Death in the IPLB-LdFB Insect Cell Line: Facts and Implications
By D. MalagoliThe present review summarizes findings on stress-induced cell death in the IPLB-LdFB insect cell line derived from the larval fat body of the lepidopteron Lymantria dispar. Apoptotic, oncotic and autophagic cell death have been described in these cells as a consequence of oxidative stress or ATP deprivation, and similarities between IPLB-LdFB and mammalian apoptotic pathways have been highlighted. Furthermore, startin Read More
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Mechanisms and Immunological Roles of Apoptosis in Molluscs
Authors: Kazutaka Terahara and Keisuke G. TakahashiMolluscan defense mechanisms are regulated to innate immunity, which is largely dependent on cellular components such as hemocytes possessing phagocytic and bactericidal activities. Among immune responses, apoptosis is an indispensable process because it enables the adequate clearance of damaged, senescent and infected cells without inflammation. Available information related to the molecular mechanisms o Read More
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A Tale of Death and Life: Natural Apoptosis in the Colonial Ascidian Botryllus schlosseri (Urochordata, Ascidiacea)
Authors: Loriano Ballarin, Paolo Burighel and Francesca CimaThe colonial ascidian Botryllus schlosseri forms new zooids by blastogenesis, through the formation of palleal buds which progressively grow and mature until adults are formed. At a temperature of 19°C, adult zooids remain active for about one week; then they contract, close their siphons and are gradually resorbed, being replaced by buds which reach functional maturity, open their siphons and begin their filtering activity Read More
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Fish and Apoptosis: Molecules and Pathways
Authors: N. M.S. dos Santos, A. d. Vale, M. I.R. Reis and M. T. SilvaApoptosis is a genetically controlled and evolutionarily conserved form of active cell death, albeit with an increase in complexity with continuing development. A high conservation at the functional and molecular level has been described between the players of the apoptotic machinery in invertebrates (Caenorhabditis elegans and Drosophila) and mammals. However, fish represent an excellent and advantageous model fo Read More
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Fish and Apoptosis: Studies in Disease and Pharmaceutical Design
Authors: N. M.S. dos Santos, M. T. Silva and A. d. ValeThe relevance of fish research has been rising due to the expansion of aquaculture and to the increasing use of fish as replacements for mammals in the study of human physiological and pathological issues. Fish have much smaller genomes compared to mammals, and zebrafish, fugu, medaka and spotted green puffer fish have the sequence of their genomes completed or near completion. Fish have several of the virtues of Dro Read More
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Cell Death in Mammalian Development
Authors: Z. Zakeri, C. Penaloza, S. Orlanski, Y. Ye, T. Entezari-Zaher and M. JavdanDuring embryogenesis there is an exquisite orchestration of cellular division, movement, differentiation, and death. Cell death is one of the most important aspects of organization of the developing embryo, as alteration in timing, level, or pattern of cell death can lead to developmental anomalies. Cell death shapes the embryo and defines the eventual functions of the organs. Cells die using different paths; understandin Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
- Issue 36
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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